Trends in miniaturized biosensors for point-of-care testing

Liu, Dan; Wang, Junxia; Wu, Lingling; Huang, Yishun; Zhang, Yuqian; Zhu, Mingyang; Wang, Yang; Zhu, Zhi; Yang, Chaoyong

doi:10.1016/j.trac.2019.115701

Cited by 171 publications

(79 citation statements)

References 110 publications

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“…For nanoPCR to be used in clinical settings, we envision further technical developments: (1) establishing MPN quality control and good manufacturing practice for mass production; (2) redesigning fluidic cartridges to minimize hands-on times in RNA extraction 44 ; and (3) exploring new assay methods, such as heat-inactivated lysis 45 , to offer sample-in and answer-out tests. These efforts will expand nanoPCR's utility in remote or resource-limited settings 46,47 . NanoPCR could also be applied for the prompt diagnosis of other infections, such as acquired immunodeficiency syndrome, tuberculosis and hepatitis [48][49][50] .…”

Section: Resultsmentioning

confidence: 99%

Fast detection of SARS-CoV-2 RNA via the integration of plasmonic thermocycling and fluorescence detection in a portable device

et al. 2020

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Section: Resultsmentioning

confidence: 99%

Fast detection of SARS-CoV-2 RNA via the integration of plasmonic thermocycling and fluorescence detection in a portable device

et al. 2020

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“…As a distinctive advantage, biosensors are often amenable to being miniaturized using microfluidics systems which lead to lower cost, portability, and rapid operation. Advances in hardware technology allow biosensors to be scaled down, making them portable, less toxic to the environment, and increase their penetration and sensitivity [ 33 ]. Moreover, most of the time, they show higher sensitivity and stability compared to conventional sensing methods [ 34 ].…”

Section: Biosensors Design For Detection Of Npsmentioning

confidence: 99%

Emerging biosensors in detection of natural products

Piroozmand

Mohammadipanah

Faridbod

2020

Synthetic and Systems Biotechnology

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Natural products (NPs) are a valuable source in the food, pharmaceutical, agricultural, environmental, and many other industrial sectors. Their beneficial properties along with their potential toxicities make the detection, determination or quantification of NPs essential for their application. The advanced instrumental methods require time-consuming sample preparation and analysis. In contrast, biosensors allow rapid detection of NPs, especially in complex media, and are the preferred choice of detection when speed and high throughput are intended. Here, we review diverse biosensors reported for the detection of NPs. The emerging approaches for improving the efficiency of biosensors, such as microfluidics, nanotechnology, and magnetic beads, are also discussed. The simultaneous use of two detection techniques is suggested as a robust strategy for precise detection of a specific NP with structural complexity in complicated matrices. The parallel detection of a variety of NPs structures or biological activities in a mixture of extract in a single detection phase is among the anticipated future advancements in this field which can be achieved using multisystem biosensors applying multiple flow cells, sensing elements, and detection mechanisms on miniaturized folded chips.

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“…The popularization of POCT is getting an increase of interest in healthcare diagnostics. However, there are significant challenges that exist in the development of simple, fast, easy to use, highly specific, and sensitive biosensors for POC testing [55]. Therefore, more attention should be given to developing analytical devices as well as biosensors.…”

Section: Biosensors and Other Novel Methods For Sars-cov-2 Testingmentioning

confidence: 99%

Newly developed diagnostic methods for SARS-CoV-2 detection

Saatçi

2020

Turkish Journal of Biochemistry

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The emergence of SARS-CoV-2, responsible for COVID-19 disease, has caused a substantial worldwide pandemic and has become a significant public health problem. World Health Organization (WHO) has declared COVID-19 as a devastating health emergency for all countries. Public health officials continue to monitor the situation closely to control this new virus-related outbreak. In order to continue to manage this pandemic, a fast and sensitive diagnosis of COVID-19 is attempted. Emerging tests have become an essential part of the management of the COVID-19 crisis. This review article aims to provide a detailed explanation of ongoing and new diagnostic technologies for SARS-CoV-2 and a summary of method principles. Examples of new diagnostic methods for providing efficient and rapid diagnostic tests for managing the SARS-CoV-2 outbreak are also mentioned.

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Trends in miniaturized biosensors for point-of-care testing

Cited by 171 publications

References 110 publications

Fast detection of SARS-CoV-2 RNA via the integration of plasmonic thermocycling and fluorescence detection in a portable device

Fast detection of SARS-CoV-2 RNA via the integration of plasmonic thermocycling and fluorescence detection in a portable device

Emerging biosensors in detection of natural products

Newly developed diagnostic methods for SARS-CoV-2 detection

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