Trends in Peptic ulcer Mortality in Sydney from 1971 to 1987

Systematic review of peptic ulcer disease incidence rates: do studies without validation provide reliable estimates?

“…After screening the titles, 395 abstracts and 119 complete articles were reviewed, and 88 were selected for detailed evaluation. Of these, 59 were rejected for the reasons as follows: the study population was not a general population or the IRs were reported for NSAID users and non‐users, but no data were provided for estimating incidence among the general population ( n = 15); the outcome was UGIB, but the percentage of bleeding cases caused specifically by peptic ulcer was not provided ( n = 5); the same population was used by different studies ( n = 11), and only the most recent one is included; no IR estimates, person–time, or number of cases were available ( n = 13); the measure of frequency was prevalence rather than incidence ( n = 4); only mortality or operation rate was reported ( n = 9); and the outcome was DU or GU alone ( n = 1) . We excluded another study because it used a rough approximation of population at risk (denominator); moreover, it was the only eligible article from a non‐Western country .…”

Some factors associated with mortality in perforated peptic ulcer: A case‐control study

“…Smoking status was known in 74% of cases and 84% of controls. There were no significant differences between cases and controls with respect to tobacco use (respective OR for smoking [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] and 20+cigarettes daily were 0.77 and 0.78; P= 0.3).…”

“…Of the 66 non-surgical cases known to have had symptoms, the correct diagnosis was made (or at least the need for urgent laparotomy was recognized) before death in 13 of 33 who died < 24 h after presentation, and within 2 4 h in 17 of 33 who survived > 24 h; all 30 cases were considered unfit for surgery. Of the remaining 16 cases who survived > 24 h, 12 were misdiagnosed until autopsy, and four were unfit for surgery when diagnosed 3-6 days after pain onset. In the three controls treated conservatively, diagnosis was made within 24 h of admission in two and after 10 days in one.…”

The Evolution of Laparoscopic Surgery in Routine Health Care

“…Use of combination drug therapies to eradicate Helicobacter pylori is a more recent development in ulcer treatment. Despite the widespread use of drug therapy, overall mortality rates associated with peptic ulcers have not decreased over a period of 15 years and may be rising (16). Costs to health programs are substantial.…”