Trends in polypharmacy and potential drug-drug interactions across educational groups in elderly patients in Sweden for the period 1992  2002

Haider, Syed Imran; Johnell, Kristina; Thorslund, Mats; Fastbom, Johan

doi:10.5414/cpp45643

Cited by 161 publications

(122 citation statements)

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“…9 Concurrent use of many drugs (polypharmacy) 10 is common in older adults 11 and is a risk factor for adverse drug reactions and drug-drug interactions (DDIs). 8,[11][12][13] In addition, due to altered pharmacokinetics and pharmacodynamics in old age, elderly patients are particularly sensitive to drugs and at increased risk of adverse drug reactions. [14][15][16] Polypharmacy have also proven to be associated with unplanned re-hospitalisation.…”

Section: Introductionmentioning

confidence: 99%

Time trends in 20 years of medication use in older adults: Findings from three elderly cohorts in Stockholm, Sweden

Craftman

Johnell

Fastbom

et al. 2016

Archives of Gerontology and Geriatrics

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Section: Introductionmentioning

confidence: 99%

Time trends in 20 years of medication use in older adults: Findings from three elderly cohorts in Stockholm, Sweden

Craftman

Johnell

Fastbom

et al. 2016

Archives of Gerontology and Geriatrics

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“…This growth in the older population associated with noncommunicable chronic diseases that affect this age group results in greater need for health care services, and, consequently, in governmental investments in public health 5 . This fact has directly influenced the general use of drugs including benzodiazepines (BZD) by older people 6 . The use of these substances has been associated, in the elderly, to increased number of falls [7][8][9] , decreased cognitive functioning 10 , dementia 11 pneumonia 12 , weight gain and adverse effects on glycidic and lipid metabolisms 13 .…”

Section: Introductionmentioning

confidence: 99%

Benzodiazepine use and associated factors in elderly in the city of Dourados, MS, Brazil

Cunha

Souza

Cattanio

et al. 2015

J. bras. psiquiatr.

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Objective: The use of benzodiazepines (BZD) and associated factors in the elderly of Dourados, MS, Brazil was investigated. Methods: This is a cross-sectional population-based study using a multistage sampling design. Participants were 1,022 individuals aged ≥ 60 years. Measurements: socioeconomic status, schooling, demographic aspects, marital status, physical activity, hospitalizations, self-rated health, use of alcohol beverages and smoking were assessed by standard questionnaire. The drugs used were obtained by checking the prescription or package and classified according to the Anatomical Therapeutic Chemical Index. Chi-square test, Chi-square for linear tendency, Fisher's exact test and Poisson regression were used to assess association between variables. Results: The prevalence of use of BZD was 6.5% (CI95%: 5.1-8.2%). The oldest group (PR: 1.60 for 70-79 years and PR: 1.79 for ≥ 80 years), non-use of alcohol (PR: 4.14) and use of antidepressants (PR: 8.73) were the statistically associated characteristics. Conclusions: The prevalence of use of BZD in the study population was low, similar to findings of more recent Brazilian studies and lower than those obtained in international studies. The prevalence of use of BZD increased with aging and use of antidepressants. REsUMOObjetivo: Foi investigado o uso de benzodiazepínicos (BZD) e fatores associados em idosos no município de Dourados, MS. Métodos: Delineamento transversal, de base populacional com amostra de conglomerados estratificada e em múltiplos estágios. Os participantes totalizaram 1.022 indivíduos com idade > 60 anos. Foi utilizado questionário padronizado com as variáveis nível econômico, escolaridade, demográficas, situação conjugal, exercícios físicos, internações hospitalares, autopercepção de saúde, uso de bebida alcoólica e fumo. Os medicamentos utilizados foram obtidos por meio da verificação da receita médica ou embalagem e classificados segundo o Anatomical Therapeutic Chemical Index. Para avaliar a associação entre as variáveis foram utilizados os testes do qui-quadrado, de tendência linear, exato de Fisher e regressão de Poisson. Resultados: A prevalência do uso de BZD foi de 6,5% (IC95%: 5,1-8,2%). A maior idade (RP: 1,60 para 70-79 anos e RP: 1,79 para > 80

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“…Although polypharmacy and its impact on drug-drug interactions has been well-described in various studies from the general population, 13,14,[25][26][27][28][29][30][31][32][33] there are limited data among the aging population of HIV-infected adults. 2,[34][35][36] Therefore, we sought to examine the potential impact of polypharmacy on the risk of drug-drug interactions between ARVs and other medications (ARV/non-ARV interactions) in a US cohort of HIV-infected adults seen in the outpatient setting.…”

Section: Introductionmentioning

confidence: 99%

Polypharmacy and Risk of Antiretroviral Drug Interactions Among the Aging HIV-Infected Population

et al. 2013

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BACKGROUND: Among aging HIV-infected adults, polypharmacy and its consequences have not been welldescribed. OBJECTIVE: To characterize the extent of polypharmacy and the risk of antiretroviral (ARV) drug interactions among persons of different ages. DESIGN AND PARTICIPANTS: Cross-sectional analysis among patients within the HIV Outpatient Study (HOPS) cohort who were prescribed ARVs during 2006-2010. MAIN MEASURES: We used the University of Liverpool HIV drug interactions database to identify ARV/non-ARV interactions with potential for clinical significance. KEY RESULTS: Of 3,810 patients analyzed (median age 46 years, 34 % ≥ 50 years old) at midpoint of observation, 1,494 (39 %) patients were prescribed ≥ 5 non-ARV medications: 706 (54 %) of 1,312 patients ≥ 50 years old compared with 788 (32 %) of 2,498 patients < 50 years. During the five-year period, the number of patients who were prescribed at least one ARV/non-ARV combination that was contraindicated or had moderate or high evidence of interaction was 267 (7 %) and 1,267 (33 %), respectively. Variables independently associated with having been prescribed a contraindicated ARV/non-ARV combination included older age (adjusted odds ratio [aOR] per 10 years of age 1.17, 95 % CI 1.01-1.35), anxiety (aOR 1.78, 95 % CI 1.32-2.40), dyslipidemia (aOR 1.96, 95 % CI 1.28-2.99), higher daily non-ARV medication burden (aOR 1.13, 95 % CI 1.10-1.17), and having been prescribed a protease inhibitor (aOR 2.10, 95 % CI 1.59-2.76). Compared with patients < 50 years, older patients were more likely to have been prescribed an ARV/non-ARV combination that was contraindicated (unadjusted OR 1.44, 95 % CI 1.14-1.82), or had moderate or high evidence of interaction (unadjusted OR 1.29, 95 % CI 1.15-1.44). CONCLUSIONS: A substantial percentage of patients were prescribed at least one ARV/non-ARV combination that was contraindicated or had potential for a clinically significant interaction. As HIV-infected patients age and experience multiple comorbidities, systematic reviews of current medications by providers may reduce risk of such exposures.

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Trends in polypharmacy and potential drug-drug interactions across educational groups in elderly patients in Sweden for the period 1992 2002

Cited by 161 publications

References 0 publications

Time trends in 20 years of medication use in older adults: Findings from three elderly cohorts in Stockholm, Sweden

Time trends in 20 years of medication use in older adults: Findings from three elderly cohorts in Stockholm, Sweden

Benzodiazepine use and associated factors in elderly in the city of Dourados, MS, Brazil

Polypharmacy and Risk of Antiretroviral Drug Interactions Among the Aging HIV-Infected Population

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Trends in polypharmacy and potential drug-drug interactions across educational groups in elderly patients in Sweden for the period 1992  2002

Cited by 161 publications

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Time trends in 20 years of medication use in older adults: Findings from three elderly cohorts in Stockholm, Sweden

Time trends in 20 years of medication use in older adults: Findings from three elderly cohorts in Stockholm, Sweden

Benzodiazepine use and associated factors in elderly in the city of Dourados, MS, Brazil

Polypharmacy and Risk of Antiretroviral Drug Interactions Among the Aging HIV-Infected Population

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Trends in polypharmacy and potential drug-drug interactions across educational groups in elderly patients in Sweden for the period 1992 2002