Trends in Premature Mortality from Acute Myocardial Infarction in American Indians/Alaska Natives in the United States from 1999 to 2020

Gonuguntla, Karthik; Sattar, Yasar; Iqbal, Kinza; Sharma, Aakanksha; Yadav, Ritu; Alharbi, Anas; Chobufo, Muchi Ditah; Naeem, Minahil; Shaik, Ayesha; Balla, Sudarshan

doi:10.1016/j.amjcard.2023.12.019

Cited by 2 publications

(1 citation statement)

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“…These data were comparable to a national database study using the Healthcare Cost and Utilization Project National Inpatient Sample from 2000 to 2018, which demonstrated that Native Americans were the second-highest population, only second to White patients, with high AMI rates, with the trend going upward from 14.0/1000 to 16.1/1000 over the course of 18 years [18]. Moreover, Native Americans have been found to have a disproportionately higher rate of premature myocardial infarction (female < 65 years, male < 55 years) as compared to all other racial groups combined, with the rate in Native Americans being 22.8% versus 14.8% in all other racial groups combined [19]. This may possibly be explained by the intricate interplay of cancer with CVD.…”

Section: Discussionmentioning

confidence: 99%

Racial Disparities in Cardiovascular and Cerebrovascular Adverse Events in Patients with Non-Hodgkin Lymphoma: A Nationwide Analysis

Uttam Chandani,

Agrawal,

Raval

et al. 2024

Medicina

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Background and Objectives: Non-Hodgkin lymphoma (NHL) has the sixth-highest malignancy-related mortality in the United States (US). However, inequalities exist in access to advanced care in specific patient populations. We aim to study the racial disparities in major adverse cardiovascular and cerebrovascular events (MACCEs) in NHL patients. Materials and Methods: Using ICD-10 codes, patients with NHL were identified from the US National Inpatient Sample 2016–2019 database. Baseline characteristics, comorbidities, and MACCE outcomes were studied, and results were stratified based on the patient’s race. Results: Of the 777,740 patients with a diagnosis of NHL, 74.22% (577,215) were White, 9.15% (71,180) were Black, 9.39% (73,000) were Hispanic, 3.33% (25,935) were Asian/Pacific Islander, 0.36% (2855) were Native American, and 3.54% (27,555) belonged to other races. When compared to White patients, all-cause mortality (ACM) was significantly higher in Black patients (aOR 1.27, 95% CI 1.17–1.38, p < 0.001) and in Asian/Pacific Islander patients (aOR 1.27, 95% CI 1.12–1.45, p < 0.001). Sudden cardiac death was found to have a higher aOR in all racial sub-groups as compared to White patients; however, it was statistically significant in Black patients only (aOR 1.81, 95% CI 1.52–2.16, p < 0.001). Atrial fibrillation (AF) risk was significantly lower in patients who were Black, Hispanic, and of other races compared to White patients. Acute myocardial infarction (AMI) was noted to have a statistically significantly lower aOR in Black patients (0.70, 95% CI 0.60–0.81, p < 0.001), Hispanic patients (0.69, 95% CI 0.59–0.80, p < 0.001), and patients of other races (0.57, 95% CI 0.43–0.75, p < 0.001) as compared to White patients. Conclusions: Racial disparities are found in MACCEs among NHL patients, which is likely multifactorial, highlighting the need for healthcare strategies stratified by race to mitigate the increased risk of MACCEs. Further research involving possible epigenomic influences and social determinants of health contributing to poorer outcomes in Black and Asian/Pacific Islander patients with NHL is imperative.

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Section: Discussionmentioning

confidence: 99%