Trends in prevalence, incidence, and residual risk of major transfusion‐transmissible viral infections in United Arab Emirates blood donors: impact of individual‐donation nucleic acid testing, 2004 through 2009

Shaer, Laila Al; Abdulrahman, Mahera; John, T. Jacob; AlHashimi, Ali

doi:10.1111/j.1537-2995.2012.03740.x

Cited by 30 publications

(29 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The prevalence of the main transfusion-transmissible viral infections (TTVIs) in the study population were previously described by Al Shaer et al26 The individual prevalences of hepatitis B virus, hepatitis C virus, and human immunodeficiency virus per 100,000 donations were 234.4, 110, and 4, respectively. Additionally, incidence rate and estimated residual risk in the previous study indicate that the current risk of TTVIs attributable to blood donation is relatively low in the UAE.…”

Section: Discussionmentioning

confidence: 99%

Analysis of blood donor pre-donation deferral in Dubai: characteristics and reasons

Shaer¹,

Sharma²,

Abdulrahman³

2017

JBM

Self Cite

View full text Add to dashboard Cite

BackgroundTo ensure an adequate and safe blood supply, it is crucial to select suitable donors according to stringent eligibility criteria. Understanding the reasons for donor deferral can help in planning more efficient recruitment strategies and evaluating donor selection criteria. This study aims to define donor pre-donation deferral rates, causes of deferral, and characteristics of deferred donors in Dubai.Materials and methodsThis retrospective study was conducted on all donors who presented for allogeneic blood donation between January 1, 2010, until June 30, 2013, in Dubai Blood Donation Centre, accredited by the American Association of Blood Banks. The donation and deferral data were analyzed to determine the demographic characteristics of accepted and deferred donors, and frequency analyses were also conducted.ResultsAmong 142,431 individuals presenting during the study period, 114,827 (80.6%) were accepted for donation, and 27,604 (19.4%) were deferred. The overall proportion of deferrals was higher among individuals less than 21 years old (35%, P<0.000), females (44% were deferred compared to 15% of males, P<0.0001), and first-time donors (22% were deferred vs 14% of repeat donors, P<0.0001). The main causes for a temporary deferral were low hemoglobin and high blood pressure.DiscussionThe deferral rate among blood donors in Dubai is relatively high compared to the internationally reported rates. This rate was higher among first-time donors and females, with low hemoglobin as the major factor leading to a temporary deferral of donors. Strategies to mitigate deferral and improve blood donor retention are urged in Dubai to avoid additional stress on the blood supply.

show abstract

Section: Discussionmentioning

confidence: 99%

Analysis of blood donor pre-donation deferral in Dubai: characteristics and reasons

Shaer¹,

Sharma²,

Abdulrahman³

2017

JBM

Self Cite

View full text Add to dashboard Cite

show abstract

“…Two studies were available from each of the following countries: Syria (44,45), Libya (46,47), Yemen (48,49), and Israel (50,51). Only one study was available from each of the following countries: Lebanon (52), Oman (53), Cyprus (54), and UAE (55). The characteristics of included studies are summarized in Table 1.…”

Section: Study Screening and Characteristics Of The Included Studiesmentioning

confidence: 99%

Seroprevalence of Hepatitis C Virus among Blood Donors in Middle Eastern Countries: A Systematic Review and Meta-Analysis

Ghaderi-Zefrehi

Sharafi

Sadeghi

et al. 2017

Iran Red Crescent Med J

View full text Add to dashboard Cite

Context: Hepatitis C virus (HCV) has been the main cause of post transfusion hepatitis. Long-term hepatitis can ultimately result in cirrhosis and hepatocellular carcinoma. Viral hepatitis, especially HCV infection, is a major health concern in the Middle East. The current study carried out a systematic search concerning HCV seroprevalence among blood donors in Middle Eastern countries. Evidence Acquisition: Articles were identified through searching databases including PubMed, Scopus, and Web of Science. We reviewed systematically all studies reporting HCV seroprevalence among blood donors in Middle Eastern countries. Results: A total of 5662 relevant records were identified by the electronic search, of which a total of 47 studies were identified as eligible papers that were meta-analyzed for the pooled seroprevalence of HCV among blood donors. Overall, HCV seroprevalence among blood donors in Middle Eastern countries was estimated 0.88% (95%CI = 0.79% -0.97%). The highest pooled HCV seroprevalence rate was related to Egypt (5.76% [95%CI = 3.30% -8.22%]), Libya (1.56% [95%CI = 0.99% -2.13%]), and Yemen (1.09% [95%CI = 0.69% -1.50%]) while the lowest pooled seroprevalence rate was in Iran and Israel with the rates of 0.14% (95%CI = 0.12% -0.17%) and 0.16% (95%CI = 0.06% -0.25%), respectively. Results of annual HCV seroprevalence suggest that there is a decrease in seroprevalence rate of HCV over time among blood donors in Egypt, Iran, Oman, Lebanon, Libya, and Saudi Arabia. Conclusions: Our results showed that the trend of HCV seroprevalence over time among Middle Eastern blood donors was decreasing. It suggests that recent safety measures implemented in Middle Eastern countries have been effective.

show abstract

“…Transfusion-related infections and consequent fatalities continue to be reported in quite a few publications [168,169], and blood is currently not tested for many potentially dangerous known pathogens. In order to guarantee the safety of blood products from pathogenic microbes, PDT is an alternative approach with the main advantage of being potentially efficient against viruses, bacteria, fungi, and parasites.…”

Section: Photodynamic Therapy As An Anti-infectivementioning

confidence: 99%

Light based anti-infectives: ultraviolet C irradiation, photodynamic therapy, blue light, and beyond

Yin

Dai

Avci

et al. 2013

Current Opinion in Pharmacology

242

172

View full text Add to dashboard Cite

Owing to the worldwide increase in antibiotic resistance, researchers are investigating alternative anti-infective strategies to which it is supposed microorganisms will be unable to develop resistance. Prominent among these strategies, is a group of approaches which rely on light to deliver the killing blow. As is well known, ultraviolet light, particularly UVC (200–280nm), is germicidal, but it has not been much developed as an anti-infective approach until recently, when it was realized that the possible adverse effects to host tissue were relatively minor compared to its high activity in killing pathogens. Photodynamic therapy is the combination of non-toxic photosensitizing dyes with harmless visible light that together produce abundant destructive reactive oxygen species (ROS). Certain cationic dyes or photosensitizers have good specificity for binding to microbial cells while sparing host mammalian cells and can be used for treating many localized infections, both superficial and even deep-seated by using fiber optic delivered light. Many microbial cells are highly sensitive to killing by blue light (400–470 nm) due to accumulation of naturally occurring photosensitizers such as porphyrins and flavins. Near infrared light has also been shown to have antimicrobial effects against certain species. Clinical applications of these technologies include skin, dental, wound, stomach, nasal, toenail and other infections which are amenable to effective light delivery.

show abstract

Trends in prevalence, incidence, and residual risk of major transfusion‐transmissible viral infections in United Arab Emirates blood donors: impact of individual‐donation nucleic acid testing, 2004 through 2009

Cited by 30 publications

References 42 publications

Analysis of blood donor pre-donation deferral in Dubai: characteristics and reasons

Analysis of blood donor pre-donation deferral in Dubai: characteristics and reasons

Seroprevalence of Hepatitis C Virus among Blood Donors in Middle Eastern Countries: A Systematic Review and Meta-Analysis

Light based anti-infectives: ultraviolet C irradiation, photodynamic therapy, blue light, and beyond

Contact Info

Product

Resources

About