Trends in primeval β-hCG level increment after fresh and frozen-thawed IVF embryo transfer cycles

Grin, Leonti; Indurski, Atara; Leytes, Sophia; Rabinovich, M. G.; Friedler, Shevach

doi:10.1080/09513590.2018.1519789

Cited by 12 publications

(8 citation statements)

References 22 publications

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“…Our findings of a higher initial βhCG in frozen compared with fresh IVF cycles are consistent with previous research [30]. Furthermore, two previous studies have shown that after the initial βhCG difference in fresh and frozen IVF cycles, the rate of rise was consistent [9,30].…”

Section: Discussionsupporting

confidence: 92%

“…A previous study using these data concluded that the risk of IPD was decreased in frozen compared with fresh IVF cycles [5], which correlates with frozen cycles having a more "physiologic" environment that favors improved early placentation with a natural or artificial preparation [29]. Our findings of a higher initial βhCG in frozen compared with fresh IVF cycles are consistent with previous research [30]. Furthermore, two previous studies have shown that after the initial βhCG difference in fresh and frozen IVF cycles, the rate of rise was consistent [9,30].…”

Section: Discussionsupporting

confidence: 90%

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Association of Early Beta Human Chorionic Gonadotropin With Ischemic Placental Disease in Singleton Pregnancies After In Vitro Fertilization

Shah¹,

Modest²,

Hacker³

et al. 2022

Cureus

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Objectives: To evaluate whether an initial or two-day percent increase in serum beta-human chorionic gonadotropin (βhCG) is associated with ischemic placental disease (IPD) in singleton pregnancies after autologous or donor IVF.Study design: This was a secondary analysis of a retrospective cohort study of deliveries linked to IVF cycles at a single academic tertiary hospital and infertility treatment center. We included all patients (≥18 years old) who had a singleton live birth or intrauterine fetal demise (IUFD) resulting from either autologous fresh (n=1,347), autologous frozen (n=454), or donor (n=253) IVF cycles.Main outcome reassures: The primary outcome was a composite outcome of IPD or IUFD due to placental insufficiency. IPDs included preeclampsia, placental abruption, and small for gestational age (SGA).Results: Neither initial βhCG nor two-day percent increases in βhCG were associated with an increased risk of IPD for any type of IVF cycle. Initial and two-day percent increases in βhCG were significantly higher when comparing frozen with fresh IVF and donor with autologous IVF (all P≤0.01).Conclusions: Among singleton autologous and donor IVF cycles, the initial and two-day percent increase in serum βhCG were not associated with IPD or its components. However, significant βhCG differences existed by cycle type and oocyte source.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 90%

Association of Early Beta Human Chorionic Gonadotropin With Ischemic Placental Disease in Singleton Pregnancies After In Vitro Fertilization

Shah¹,

Modest²,

Hacker³

et al. 2022

Cureus

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“…Our previous study has not shown any statistically significant difference in β-hCG levels 13 days after transferring fresh or vitrified-warmed blastocyst. However, recent data suggest that the rate of β-hCG increase is higher following FET [23], so there is a possibility that the difference becomes apparent later in the pregnancy. In the present study, blood sampling was performed approximately 15 days later than in the previous study, which may explain disparity in results.…”

Section: Discussionmentioning

confidence: 99%

Maternal serum levels of angiogenic markers and markers of placentation in pregnancies conceived with fresh and vitrified-warmed blastocyst transfer

Reljič

Porović

2019

J Assist Reprod Genet

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The aim of the study was to compare the levels of angiogenic markers and markers of placentation between pregnancies conceived with fresh (ET) and vitrified-warmed blastocyst transfer (FET). Methods Women with singleton pregnancies resulting from fresh ET or FET during the period between 2013 and 2017 were included in this prospective observational study. Fresh ET was performed in a stimulated and FET in natural cycle. At 6-7 weeks of gestation, after ultrasound confirmation of a single gestational sac with a viable embryo, serum levels of free β-hCG, pregnancy-associated plasma protein A (PAPP-A), placental growth factor (PIGF) and fms-like tyrosine kinase (sFlt-1) were measured. Data on the patients' characteristics, pregnancy complications and outcomes were collected from a questionnaire and National Perinatal Information System of Slovenia. Results Among 211 pregnancies, 126 were achieved with fresh ET and 85 with FET. There were no significant differences in perinatal outcome, pregnancy complication and PIGF level between the fresh ET and FET group. Women achieving pregnancy with FET had significant higher levels of free β-hCG (40.20 ± 30.62 IU/L vs. 28.74 ± 23.52, p = 0.002), PAPP-A (0.09 ± 0.06 vs. 0.06 ± 0.05 IU/L, p = 0.004) and sFlt-1 (596.19 ± 283.06 vs. 436.53 ± 248.23 pg/L, p < 0.0001) compared to women having conceived with fresh ET. There were no significant differences in the levels of evaluated biomarkers between patients with different pregnancy outcomes and complications. Conclusion Levels of angiogenic markers and markers of placentation differ between pregnancies achieved with fresh ET and FET which may reflect altered implantation and early placentation with some forms of assisted reproductive technologies.

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“…У акушеров вызывает обеспокоенность то, что частота самопроизвольных абортов после ЭКО по-прежнему остается высокой. В настоящее время доказано, что у 2 / 3 наблюдаемых неэффективность ЭКО обусловлена низкой восприимчивостью (рецептивностью) эндометрия [9][10][11][12].…”

Section: обзоры Reviewsunclassified

“…В настоящее время установлено, что эндометрий в естественном цикле претерпевает ряд морфологических, клеточных и молекулярных изменений, необходимых для открытия «имплантационного окна» и формирования восприимчивости к оплодотворенной яйцеклетке [11]. В результате взаимодействия эмбриона и эндометрия экспрессируется большое количество сигнальных молекул, выполняющих паракринную, аутокринную, интракринную и юкстакринную функции [19].…”

Section: рецептивность эндометрияunclassified

The role of pregravid preparation in increased efficacy of IVF

Papysheva¹,

Konoplyannikov²,

Karaganova³

2019

Ross. vestn. akush.-ginekol.

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По данным Всемирной организации здравоохранения (ВОЗ) [1, 2], ежегодно регистрируется около 2 млн новых бесплодных супружеских пар, и их число неуклонно растет, что является общей проблемой во всем мире. Эффективным методом лечения бесплодия считаются вспомогательные репродуктивные технологии (ВРТ) и в первую очередь экстракорпоральное оплодотворение (ЭКО) [3, 4].

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Trends in primeval β-hCG level increment after fresh and frozen-thawed IVF embryo transfer cycles

Cited by 12 publications

References 22 publications

Association of Early Beta Human Chorionic Gonadotropin With Ischemic Placental Disease in Singleton Pregnancies After In Vitro Fertilization

Association of Early Beta Human Chorionic Gonadotropin With Ischemic Placental Disease in Singleton Pregnancies After In Vitro Fertilization

Maternal serum levels of angiogenic markers and markers of placentation in pregnancies conceived with fresh and vitrified-warmed blastocyst transfer

The role of pregravid preparation in increased efficacy of IVF

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