Trends in prostate cancer in elderly in Denmark, 1980–2012

Poulsen, Mads Hvid; Dysager, Lars; Gerke, Oke; Lund, Lars

doi:10.3109/0284186x.2015.1115120

Cited by 7 publications

(6 citation statements)

References 17 publications

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“…National, epidemiological data have shown increased incidence and mortality of cancer with age (25)(26)(27)(28)(29). In the present study, the relation between sex and survival duration was still statistically significant after adjusting for age.…”

Section: Discussionsupporting

confidence: 45%

Long-term Survival After Surgical Treatment of Spinal Metastasis – The Predictive Role of Sex

et al. 2020

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Background/Aim: An increasing number of patients undergo surgical treatment for metastatic spinal cord compression (MSCC). However, the possible role of sex as an independent predictor of long-term survival has not been studied. This study aimed to examine whether sex is associated with long-term survival after surgical treatment in patients with MSCC. Patients and Methods: A total of 110 patients were operated on for MSCC from 2005 through 2006. The relation between sex and overall survival was investigated. The followup period was 10 years. Results: Survival time was significantly longer for women compared to men (mean±SD: 29±5.2 vs. 14±3.6 month (p=0.01). With adjusted analysis, this difference remained statistically significant. After adjusting for specific primary tumor type and time since surgery, the hazardratio of 10-year survival for men compared to women was 1.47 (95% confidence intervaI=1. 01-2.18, p=0.048). Conclusion: These findings indicate that sex is associated with long-term survival in patients treated for MSCC.

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Section: Discussionsupporting

confidence: 45%

Long-term Survival After Surgical Treatment of Spinal Metastasis – The Predictive Role of Sex

et al. 2020

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“…The present results are therefore consistent with the effect of increased PSA testing and subsequent beneficial treatment of earlier diagnosed cases in three of the four countries. However, in Denmark, where PSA testing remained limited and curative radical prostatectomy for localized prostate cancer was not introduced until 1995, the decline in mortality among men younger than 75 years occurred before any substantial observed change in incidence rates. Consequently, factors other than PSA testing and subsequent early treatment must have been responsible for the initial years with favorable mortality trends in Denmark.…”

Section: Discussionmentioning

confidence: 99%

Prostate and breast cancer in four Nordic countries: A comparison of incidence and mortality trends across countries and age groups 1975–2013

Kvåle

Myklebust

Engholm

et al. 2017

Intl Journal of Cancer

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In recent decades, management of prostate and breast cancer patients has changed considerably. The purpose of our study is to interpret patterns of prostate and breast cancer incidence and mortality in four Nordic countries across age groups and time periods. Prostate and breast cancer incidence and mortality data (1975-2013) were obtained from the NORDCAN database. Joinpoint regression models were used to identify changes in the trends. A more prominent increase in prostate than breast cancer incidence was observed. From the mid-1990s, mortality rates in patients below 75 years of age have decreased for both cancers in all four countries. The relative decline in breast cancer mortality from 1985-1989 to 2009-2013 were largest in women under 50 years of age, with reductions in mortality rates ranging from 38% in Finland to 55% in Denmark. In the age group 55-74 years, mortality rates for prostate cancer declined more than for breast cancer in all countries except Denmark, ranging from 14% in Denmark to 39% in Norway. The substantial decrease in breast cancer mortality in women below regular screening age and the reductions in mortality from both cancers in Denmark from the mid-1990s are consistent with beneficial contributions from improved treatment besides mammography screening and increased PSA testing. Alongside similar mortality decreases, the larger increases in prostate cancer incidence as compared to breast cancer indicate that a higher proportion of prostate cancer cases are overdiagnosed.

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“…The US had higher rates of prostate cancer in the oldest-old than in Korea or Denmark. Prostate cancer was fairly stable across all age groups in Denmark (Poulsen et al, 2016), but steadily declined in the US and Korea after ages 70-74 (Harding et al, 2012;Song and Jeon, 2015). The lowest rates of breast and lung cancers were in the 90+, with peak rates of incidence being in the 80-84 age range before decreasing at 85+ in Denmark and US (Harding et al, 2012; Jensen et al, 2016; Kristiansen et al, 2016).…”

Section: Cancer Incidencementioning

confidence: 99%

Cancer—Incidence, prevalence and mortality in the oldest-old. A comprehensive review

Evans

Fischer

et al. 2017

Mechanisms of Ageing and Development

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Chronic health conditions are commonplace in older populations. The process of aging impacts many of the world's top health concerns. With the average life expectancy continuing to climb, understanding patterns of morbidity in aging populations has become progressively more important. Cancer is an age-related disease, whose risk has been proven to increase with age. Limited information is published about the epidemiology of cancer and the cancer contribution to mortality in the 85+ age group, often referred to as the oldest-old. In this review, we perform a comprehensive assessment of the most recent (2011-2016) literature on cancer prevalence, incidence and mortality in the oldest-old. The data shows cancer prevalence and cancer incidence increases until ages 85-89, after which the rates decrease into 100+ ages. However the number of overall cases has steadily increased over time due to the rise in population. Cancer mortality continues to increase after age 85+. This review presents an overview of plausible associations between comorbidity, genetics and age-related physiological effects in relation to cancer risk and protection. Many of these age-related processes contribute to the lowered risk of cancer in the oldest-old, likewise other certain health conditions may "protect" from cancer in this age group.

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Trends in prostate cancer in elderly in Denmark, 1980–2012

Cited by 7 publications

References 17 publications

Long-term Survival After Surgical Treatment of Spinal Metastasis – The Predictive Role of Sex

Long-term Survival After Surgical Treatment of Spinal Metastasis – The Predictive Role of Sex

Prostate and breast cancer in four Nordic countries: A comparison of incidence and mortality trends across countries and age groups 1975–2013

Cancer—Incidence, prevalence and mortality in the oldest-old. A comprehensive review

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