Trends in CE ‐ MS and Applications

Abstract

Capillary electrophoresis coupled to mass spectrometry with electrospray ionization ( CE ‐ ESI ‐ MS ) is becoming a very powerful tool utilized not only in academic research but also in industrial applications. This overview covers mainly the research published in the past decade and is divided into two main parts. Since the crucial parameter of the CE ‐ MS is the interface design, the first part of this chapter covers the instrumentation developments. The second part covers selected applications of the CE ‐ ESI ‐ MS in the field of proteomics, glycomics and metabolomics.

Recent advances in combination of capillary electrophoresis with mass spectrometry: Methodology and theory

“…An interesting modification of a sheathless emitter is to separate analytes directly inside a long nanoESI tip. The physicochemical properties of this simple construction were investigated and separation capability tested with complex samples of cytochrome c tryptic digests . Several modifications of a simple sheathless interface based on a thin conducting liquid film were published by Her and co‐workers .…”