Trends in NLRP3 inflammasome research in ischemic stroke from 2011 to 2022: A bibliometric analysis

Abstract

BackgroundIschemic stroke is a leading cause of permanent disability and death globally. The nucleotide‐biding oligomaerization domain (NOD)‐like receptor family pyrin domain‐containing 3 (NLRP3) inflammasome is a multi‐protein complex that plays a role in ischemic stroke. Recently, research on the role of NLRP3 in ischemic stroke has developed rapidly worldwide. However, there is no bibliometric analysis of NLRP3 in ischemic stroke to date.AimThrough bibliometric analysis, the aim of this study was to assess the current state of research on NLRP3 in the field of ischemic stroke research worldwide over the past 12 years and to identify important results, major research areas, and emerging trends.MethodsPublications related to NLRP3 in ischemic stroke from January 1, 2011 to December 31, 2022 were obtained from the Web of Science Core Collection (WoSCC). We used HistCite, VOSviewer, CiteSpace, and Bibliometrix for bibliometric analysis and visualization. The Total Global Citation Score (TGCS) was employed to assess the impact of publications.ResultsWe found that research of NLRP3 in ischemic stroke developed rapidly starting in 2011. 601 relevant studies have been published in 245 journals over the past 12 years. Journal of Neuroinflammation and International Immunopharmacology were the most productive journals and Journal of Neuroinflammation was the most cited journal. Additionally, Stroke and Journal of Cerebral Blood Flow & Metabolism were the most co‐cited journal. The most productive country was China (records = 430) and the most productive university was the Zhejiang University (records = 24). Arumugam TV (TGCS = 949) was the most cited author in this field. NLRP3 inflammasome activation, nf–κb, oxidative stress, and inflammation were the knowledge bases for the research in this field.ConclusionThis study is a scientometric study utilizing quantitative and qualitative methods to comprehensively review the publications on NLRP3 in ischemic stroke. This information provides a reference for scholars to further study NLRP3 in ischemic stroke.

Knowledge Structure and Emerging Trends of Mild Cognitive Impairment with Dyssomnias in Recent 20 Years: A Bibliometric Analysis via CiteSpace and VOSviewer

“…VOSviewer, a widely employed visualization tool for scientometric analyses [ 15 ], facilitates the generation of maps that visually represent relationships among various elements, such as authors, keywords, journals, or research institutions, based on patterns of cooccurrence or cocitation. The cooperation network diagram visualizes collaboration patterns.…”

Bibliometric and visual analysis of ACE2/Ang 1–7/MasR axis in diabetes and its microvascular complications from 2000 to 2023

“…HistCite Pro 2.1 was used to calculate the total local citation score (TLCS) and total global citation score (TGCS) for publications, authors, institutions, journals and countries/regions, highlighting citation frequencies within local datasets (finally determined 349 publications) and broader recognition across the Web of Science database, respectively. TLCS values were noted to be significantly lower than TGCS values [ 8 ]. Biblioshiny R (version 4.1.4) was utilised to analysis authors' h-index, g-index, m quotient, production over time, adherence to Lotka's law, and journals' compliance with Bradford's law [ 8 , 9 ].…”

“…TLCS values were noted to be significantly lower than TGCS values [ 8 ]. Biblioshiny R (version 4.1.4) was utilised to analysis authors' h-index, g-index, m quotient, production over time, adherence to Lotka's law, and journals' compliance with Bradford's law [ 8 , 9 ]. The m-index is determined by calculating the median number of citations that the papers in a scientist's h-core receive, with the h-core being defined by the h-index.…”

“…Bibliometrics is a methodological approach that quantifies and analyzes the quantity, quality, and impact of scientific literature, playing a crucial role in assessing research outcomes and academic contributions [ 7 ]. Compared to traditional review articles, bibliometrics offers researchers an objective and quantifiable perspective, enabling a more thorough understanding and evaluation of academic research achievements, hotspots, and trends within a specific field or disease, thus establishing a foundation for future research endeavors [ 8 ]. However, bibliometric studies on the ACE2/Ang 1–7/MasR axis related to diabetes and its microvascular complications are scarce.…”

Editorial: Novel perspectives on the NLRP3 inflammasome

“…The NLRP3 inflammasome can be activated by pressure overload and controls neural signals that may improve cardiovascular disease by modulating cardiac inflammation (4). Recent bibliometric studies indicate that NLRP3 inflammasome has been of great interest in the field of ischemic stroke and neurological disease (5,6). Growing evidence highlights NLRP3 inflammasome is a promising therapeutic target in treating ischemic stroke and neurological disease.…”