Dry days are crucial in precipitation variability and water scarcity, particularly in Mediterranean regions facing increasing aridity. Despite their importance, most research focuses on precipitation amounts and temporal dynamics. This study addresses this gap by analyzing dry days’ temporal and spatial variability in central Chile (32–40 S), a region experiencing prolonged drought. We examined dry day patterns from 1960 to 2021 using high-resolution gridded precipitation data, defining dry days with five precipitation thresholds (0.10, 1, 2.5, 5, and 10 mm/day). Principal component and trend analyses were employed to characterize spatial and temporal variability. Results reveal a spatial pattern of dry days closely following precipitation patterns, with more dry days in northern and coastal areas. The first principal component explains 70–80% of the variance, and clustering methods allowed the definition of five homogeneous regions with distinct monthly dry-day characteristics. Long-term trends show a significant increase in annual dry days south of 38°S, while trends are weaker and non-significant further north. Notably, trend direction is highly sensitive to the analysis period, with some regions showing opposing trends before and after 1982. The 2010–2019 megadrought is detectable in decadal anomalies. We found links between dry day anomalies and large-scale climate patterns, suggesting modulation by changes in subtropical and extratropical atmospheric circulation. This comprehensive characterization of dry day climatology and variability provides crucial insights for water resource management and climate change adaptation in central Chile and similar Mediterranean regions worldwide. Our findings highlight the importance of considering dry day frequency in drought assessment and water planning, contributing to a more nuanced understanding of precipitation patterns in Mediterranean climates.