Trends in serological markers of transfusion transmissible infections in blood donations at the Bamenda Hospital-based Blood Service, Cameroon

Samje, Moses; Fondoh, Victor N; Nguefack‐Tsague, Georges; Kamalieuk, Laure K.J.; Mbanya, Dora; Murphy, Edward L.; Tagny, Claude Tayou

doi:10.1016/j.tracli.2021.05.011

Cited by 6 publications

(7 citation statements)

References 23 publications

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“…The overall prevalence of the TTIs in the study was 17.6%. This was slightly higher than the values from similar studies in the littoral region (13.7%) and North West 55555555555 region (10.5%) of Cameroon respectively [ 10 , 11 ]. It was also slightly higher than the values from studies in Ethiopia (12.4%) [ 19 ], Kenya (12%) [ 27 ], and Nigeria (13%) [ 28 ].…”

Section: Discussioncontrasting

confidence: 64%

“…A similar pattern has been reported in other regions within Cameroon and indeed other regions in SSA. A six-year review of blood donors at Bamenda regional hospital-based blood bank in Cameroon reported a male donor population of over 85% with 52% being between the ages of 20–29 years [ 11 ]. In a similar study, Eboumbou et al [ 10 ] reported a male-to-female ratio of 4:1 among their donor population with the majority of the donors in their third decade of life [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

“…Amongst the infected participants, 8.3% were voluntary donors while 14.3% were family replacement donors [ 10 ]. A similar study at the Bamenda hospital-based blood services reported a seroprevalence rate of 10.5% for the four conventional TTIs markers [ 11 ]. Studies from other SSA countries with similar demographics have reported similar findings in Kenya, Nigeria and Ethiopia [ 12 – 15 ].…”

Section: Introductionmentioning

confidence: 99%

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Trends in immunological markers of transfusion transmissible infections among blood donors in Mamfe District Hospital, Southwest Cameroon

Ngomtcho,

Njike Ngo Biyong,

Ekwere

et al. 2024

BMC Infect Dis

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Background Blood transfusion is associated with exposure to blood Transfusion Transmissible Infection (TTIs). The threat posed by the blood-borne pathogens is disproportionately distributed in different healthcare facilities in Cameroon. Thus, there is a need for continuous surveillance of TTIs in the country. This study aimed to assess the screening procedure for blood transfusion and determine the trend in immunological markers of TTIs among blood donors at the Mamfe District Hospital. Methods A prospective descriptive, cross-sectional and analytical study was conducted at Mamfe District Hospital from March to May 2022. A total of 165 blood donors were recruited by the consecutive sampling method. Donors were screened using both Rapid diagnostic tests,T. pallidum haemagglutination test and indirect enzyme-linked immunosorbent assay (ELISA) for the detection of TTIs. Data generated was entered into an Excel spreadsheet and analysed using the statistical software R, version 4.2.0. Statistical analysis included descriptive statistics of percentages, means ± standard deviation, and student t-test was used to compare both diagnostic techniques, and was considered significant when p < 0.05. Results A hundred and sixty-five donors were enrolled in the study with a male preponderance giving a male-female sex ratio of 22.5 and a mean age of 32.23 ± 8.60 years. The majority (75.2%) of the donors were of the O-positive blood type, repeat donors (69.1%) and were mainly family replacement and paid donors as against the voluntary blood donors (39.4% and 37.0% vs. 23.6% respectively). overall TTIs prevalence was 18.78% (31/165) (), with HBsAg being the most predominant marker at 12.12% (20/165) followed by Treponema pallidum, HCV and HIV antibodies at 4.85 (8/165), 1.21%(2/165), 0.60% (1/165) respectively. Except for the HBV, The prevalence of TTIs was higher when using a single RDT than the ELISA test, and the difference was significant (p < 0.05). Conclusion Bloodborne pathogens remain a major menace to safe blood transfusion practice in Mamfe district hospital and their detection could be easily missed if the RDT method alone is used for donor screening. Therefore, the donor screening protocol in Mamfe District Hospital should systematically incorporate a confirmation diagnostic test such as ELISA.

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Section: Discussioncontrasting

confidence: 64%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Trends in immunological markers of transfusion transmissible infections among blood donors in Mamfe District Hospital, Southwest Cameroon

Ngomtcho,

Njike Ngo Biyong,

Ekwere

et al. 2024

BMC Infect Dis

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“…13 Studies carried out in Cameroon have shown a prevalence of 2.8% with a predominance of hypotension and a seroprevalence of 10.5% in blood donations. 14,15 Numerous studies present an incidence of transfusion errors ranging from 1/60,000 to 1/30,000 and estimate that the real incidence is largely underestimated. These types of errors include mainly infectious risks, immunological and volume overloads.…”

Section: Introductionmentioning

confidence: 99%

“…This situation makes it difficult to standardize staff training needs, particularly with regard to the selection of blood donors. 13,15,21 Studies have shown that health personnel contribute significantly to the occurrence of transfusion risks. These include poor practices in blood donor selection, blood transfusion surveillance and other transfusion practices.…”

Section: Introductionmentioning

confidence: 99%

Assessing Training Needs of Health Personnel on the Process of Selecting Blood Donors and Transfusion in the West Region of Cameroon

Bashombwa¹,

Tchio-Nighie²,

Mbianda³

et al. 2022

AMEP

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Blood transfusion is a health care procedure that can expose the donor and receiver to risks. The knowledge and practices of healthcare personnel on blood transfusion are necessary to anticipate and/or prevent the occurrence of avoidable transfusion risks. The aim of this study was to assess the training needs of health personnel on blood donor selection procedure. Methods: We conducted a cross-sectional study targeting health personnel in health facilities that reported contributing in offering blood transfusion services in the West region of Cameroon between March and May 2022. A questionnaire administered face to face was used to collect data from the targeted health personnel exhaustively included from health facilities. Knowledge and practices were assessed by estimating the rate of correct answers. STATA software was used to analyze the data. Results: Of the 41 health facilities that reported offering blood transfusion services, 35 (85.3%) were covered. Category 5 and 4 health facilities were respectively 23 (65.7%) and 9 (25.7%). Among the 325 health personnel involved in transfusion, 302 (92.9%) were reached among which, 201 (66.6%) were female and 127 (42.1%) were nurses. Two hundred and ten (69.5%) had already received training on blood transfusion and 268 (88.7%) expressed a need for training on blood transfusion of which 139 (51.8%) on blood donors' selection. Sixteen (5.3%) knew how to identify blood donor and 116 (38.4) knew the minimum required tests to be performed on the donors' blood before the transfusion. Six (2.0%) out of 302 health personnel were able to select blood donors and identify minimum tests to be performed on donors' blood. Conclusion: There is a real need for training of health personnel on the blood donor selection process. Health authorities should ensure that all health personnel involved in blood transfusion receive a minimum of training in blood donor selection and testing.

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Seroprevalence of Viral Hepatitis B and Occult Hepatitis B Among Blood Donors in Africa: A Systematic Review and Meta‐Analysis

Simpore,

Bazie,

Yooda

et al. 2024

Reviews in Medical Virology

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Hepatitis B virus (HBV) Infection remains a public health problem and a threat to blood transfusion safety. The aim of this study was to summarise the scientific literature on the seroprevalence of HBV and occult HBV among blood donors in Africa. Searches were carried out in PubMed, Science Direct, Global Index Medicus and African Journals Online from 2012 to 2022. Dersimonian and Laird's random‐effects model‐based method was used for statistical analyses to estimate pooled seroprevalence at a 95% confidence interval (CI) using STATA version 14 software. Heterogeneity was assessed on the basis of Cochran's Q test and quantified by the I2 index. The methodological quality of the articles was assessed using the Joanna Brigg Institute's critical appraisal checklist. Among 90 articles included, 86 reported data in serological test that a pooled HBV seroprevalence of 5.53% (95% CI: 4.56–6.58; I2 = 99.94%) and 14 provided occult hepatitis B data. A high prevalence of 9.69% (95% CI: 8.42–11.03) was observed in the West African region. Lowest prevalence was 1.22% (95% CI: 0.74–1.83) in South Africa region. Prevalence in Africa among men was: 5.18% (95% CI: 3.97–6.54) and in women: 3.50% (95% CI: 2.45–4.71) (I2 = 99.76% and p < 0.01). While the overall pooled prevalence of occult hepatitis B was 3.18% (95% CI: 1.29–5.81). HBV seroprevalence is high in low‐resource areas of Africa, and the data generated by this situation calls for constant epidemiological surveillance. Emphasis must be placed on building blood donor loyalty and integrating molecular testing into the biological qualification of blood donations.

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Trends in serological markers of transfusion transmissible infections in blood donations at the Bamenda Hospital-based Blood Service, Cameroon

Cited by 6 publications

References 23 publications

Trends in immunological markers of transfusion transmissible infections among blood donors in Mamfe District Hospital, Southwest Cameroon

Trends in immunological markers of transfusion transmissible infections among blood donors in Mamfe District Hospital, Southwest Cameroon

Assessing Training Needs of Health Personnel on the Process of Selecting Blood Donors and Transfusion in the West Region of Cameroon

Seroprevalence of Viral Hepatitis B and Occult Hepatitis B Among Blood Donors in Africa: A Systematic Review and Meta‐Analysis

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