Trends in the Annual Incidence of Carbapenem Resistant among Gram Negative Bacilli in a Large Teaching Hospital in Makah City, Saudi Arabia

Faidah, Hani; Momenah, Aiman M.; El-Said, Hamdi M.; Barhameen, Abeer; Ashgar, Sami S.; Johargy, Ayman; Elsawy, Abdelrahman; Almalki, Wafaa; Qurashi, Samah Al

doi:10.4236/jtr.2017.54024

Cited by 11 publications

(11 citation statements)

References 25 publications

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“…While S.marcescens showed complete resistance to all antibiotics under study. The results were agreed with Faidah [17] for Amikacin, while disagreed with Tetracycline, Ceftazidime, Gentamycin, Impenem, Trimethoprim and Cefotaximeas also disagreed with Ahmed and Aziz [14] for Amoxicillin and Cefotaxime. K. pneumoniae was show complete resistance against all antibiotic, these results were consistent with Hashim [11]forAmoxicillin and Tetracycline (100%), but disagreed with the following antibiotic: Amikacin, Cefotaxime, Trimethoprim, Tobramycin, and Gentamycin which found no sensitivity to these antibiotic by bacteria (0%).…”

Section: Antibiotic Susceptibility Testsupporting

confidence: 66%

Bacteriological and Immunological Study of Rheumatoid Arthritis

2017

IJSR

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The bacterial isolation evaluate for morphological testes and biochemical microscopy, as well as identification by Api system. The highest frequency of inflectional bacteria was E. coli (41.97%), followed by E. cloacae (21.25%), P. aeruginosa (12.5%), Salmonella (10%), K. pneumoniae (7.5%) and S. marcescens (6.25%). The concentration of some cytokines IL-6, TNF was measuredby using ELISA technical. The results showed significant decrease at P≤0.05 in level of IL-6for patient serum (23.76 ± 14.01 pg/ml)compared with healthyserum(209.11 ± 76.99)pg /ml. The result of TNF showedan increase significantly at P≤0.05 in level of serum for rheumatoid arthritis patient (437.68 ± 16.80 pg /ml) compared with healthy serum (370.31 ± 26.87 pg /ml). The study found that reverse relation between IL-6 and TNF.

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Section: Antibiotic Susceptibility Testsupporting

confidence: 66%

Bacteriological and Immunological Study of Rheumatoid Arthritis

2017

IJSR

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“…This was higher than that the results of Oberoi et al [20] who reported 8.79% of coexistence, and less than [21] who reported 48.7% of the total β-lactamases. In Saudi Arabia, phenotypic studies from Makkah reported positive MBLs production with a range between 38% and 48% [22,23]. In our study, the phenotypic coexistence of ESBLs and MBLs was common in K. pneumonia (15.4%), E. coli (7.7%), and Ps.…”

Section: Discussionsupporting

confidence: 50%

The Coexistence of Extended-Spectrum β-lactamase and Metallo-β-Lactamase Genes in Gram-Negative Bacteria

Ahmed¹,

Asghar²

2021

Arch. Pharm. Pract

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The coexistence of different classes of beta-lactamases in multiple drug-resistant (MDR) bacteria has widely increased, thus rising diagnostic and treatment challenges. The study aimed at evaluating the prevalence of extended-spectrum beta-lactamase (ESBLs) and Metallo-βlactamase (MBL) genes in confirmed ESBL producing Gram-negative (G-) bacteria. A stock of 220 G-isolates were studied for producing ESBL and MBL using phenotypic and PCR methods. The results showed that ESBLs were identified in 35.4% of the isolates, out of which 32.1% were MBLs producers, the most prevalent isolates were K. pneumoniae (15.4%), E. coli (7.7%), and Ps. aeruginosa (6.4%), respectively. PCR test confirmed the presence of ≥1 ESBL and MBL genes in 78.2% and 73.1% of the isolates, respectively. CTX-M was the most prevalent gene (70.5%) followed by IMP (61.5%), TEM (27%), VIM (21.8%), and SHV (21.8%). Also, 39.7% of the isolates carried two genes, while 10.8% carried three genes, and 20.5% carried 4 genes. The combination (CTX-M+ IMP) was the most frequent (33.4%) among the isolates. The high prevalence of ESBLs and MBLs in combination was noted, especially in E. coli and K. pneumoniae. Continuous monitoring of β-lactamases coexistence in G-bacteria will help to stop their dissemination and control their spread.

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“…Carbapenemase-producing Enterobacteriaceae such as KPC and New Delhi metallo-β-lactamase NDM have achieved global dissemination and pose a serious threat to human life [ 8 , 20 ]. The Kingdom of Saudi Arabia has reported a rise in carbapenem-resistant Enterobacteriaceae , mostly from Riyadh [ 15 , 21 , 22 , 23 , 24 ] and Makkah [ 14 , 25 ].…”

Section: Discussionmentioning

confidence: 99%

ESBL Activity, MDR, and Carbapenem Resistance among Predominant Enterobacterales Isolated in 2019

Bandy

Tantry

2021

Antibiotics

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Antimicrobial-resistance in Enterobacterales is a serious concern in Saudi Arabia. The present study retrospectively analyzed the antibiograms of Enterobacterales identified from 1 January 2019 to 31 December 2019 from a referral hospital in the Aljouf region of Saudi Arabia. The revised document of the Centers for Disease Control (CDC) CR-2015 and Magiorakos et al.’s document were used to define carbapenem resistance and classify resistant bacteria, respectively. The association of carbapenem resistance, MDR, and ESBL with various sociodemographic characteristics was assessed by the chi-square test and odds ratios. In total, 617 Enterobacterales were identified. The predominant (n = 533 (86.4%)) isolates consisted of 232 (37.6%), 200 (32.4%), and 101 (16.4%) Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis, respectively. In general, 432 (81.0%) and 128 (24.0%) isolates were of MDR and ESBL, respectively. The MDR strains were recovered in higher frequency from intensive care units (OR = 3.24 (1.78–5.91); p < 0.01). E. coli and K. pneumoniae resistance rates to imipenem (2.55 (1.21–5.37); p < 0.01) and meropenem (2.18 (1.01–4.67); p < 0.04), respectively, were significantly higher in winter. The data emphasize that MDR isolates among Enterobacterales are highly prevalent. The studied Enterobacterales exhibited seasonal variation in antimicrobial resistance rates towards carbapenems and ESBL activity.

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Trends in the Annual Incidence of Carbapenem Resistant among Gram Negative Bacilli in a Large Teaching Hospital in Makah City, Saudi Arabia

Cited by 11 publications

References 25 publications

Bacteriological and Immunological Study of Rheumatoid Arthritis

Bacteriological and Immunological Study of Rheumatoid Arthritis

The Coexistence of Extended-Spectrum β-lactamase and Metallo-β-Lactamase Genes in Gram-Negative Bacteria

ESBL Activity, MDR, and Carbapenem Resistance among Predominant Enterobacterales Isolated in 2019

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