Trends in the Evaluation of Lipid Peroxidation Processes

Ilie, Mihaela; Margină, Denisa

doi:10.5772/46075

Cited by 5 publications

(8 citation statements)

References 88 publications

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“…Cell membranes are composed primarily of PHLs; the latter are particularly susceptible to the harmful effects of reactive oxygen species synthesized in large amounts as a consequence of oxidative stress. Furthermore, formation of LPPs may result in further propagation of free radical‐mediated reactions . Oxidized PCs and other PHLs play a role in the development of vascular pathologies, thus contributing to CVDs .…”

Section: Lipid Alterations In Obesitymentioning

confidence: 99%

“…LPPs play a role in the pathogenesis of IR, diabetes , chronic inflammation, atherosclerosis, CVDs and disorders being the components of metabolic syndrome , all of which are associated with obesity. Oxidative stress may result in dysfunction of the brain, lungs, heart, kidneys, blood vessels, immune system, skin, eyes, joints, gastrointestinal tract and others . Thiobarbituric acid‐reacting substances (TBARS) and malondialdehyde (MDA) are widely used as lipid peroxidation markers, and many authors observed their elevated levels during the course of obesity .…”

Section: Lipid Alterations In Obesitymentioning

confidence: 99%

“…During peroxidation, PUFAs are transformed into conjugated dienes, peroxy radicals and hydroperoxides, which then undergo cleavage, mainly to aldehydes. The list of best characterized products of oxidative degradation of PUFAs includes acrolein, MDA, 4‐hydroxyalkenals and isoprostanes . The main reactive LPPs formed from 18:2 n‐6 are 4‐hydroksy‐2 (E)‐nonenal (HNE) and 4‐okso‐2 (E)‐nonenal, both exerting cytotoxic and genotoxic effects in living cells.…”

Section: Lipid Alterations In Obesitymentioning

confidence: 99%

“…HNE can bind to proteins, and these are resultant adducts which constitute the predominant form of HNE in living systems . MDA is one of the most common LPPs originating from PUFAs . Another group of FA (18:3 n‐3, 20:5 n‐3 and 22:6 n‐3) oxidation products are phytoprostanes, isoprostanes and neuroprostanes .…”

Section: Lipid Alterations In Obesitymentioning

confidence: 99%

“…Another group of lipids, formed as a result of interaction between reactive nitrogen species and unsaturated FAs (such as oleate, linoleate and arachidonate), are nitro‐FAs that differ from their precursor lipids in terms of biological activity .…”

Section: Lipid Alterations In Obesitymentioning

confidence: 99%

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Alterations of specific lipid groups in serum of obese humans: a review

Mika

Śledziński

2016

Obesity Reviews

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Obesity is a major contributor to the dysfunction of liver, cardiac, pulmonary, endocrine and reproductive system, as well as a component of metabolic syndrome. Although development of obesity-related disorders is associated with lipid abnormalities, most previous studies dealing with the problem in question were limited to routinely determined parameters, such as serum concentrations of triacylglycerols, total cholesterol, low-density and high-density lipoprotein cholesterol. Many authors postulated to extend the scope of analysed lipid compounds and to study obesity-related alterations in other, previously non-examined groups of lipids. Comprehensive quantitative, structural and functional analysis of specific lipid groups may result in identification of new obesity-related alterations. The review summarizes available evidence of obesity-related alterations in various groups of lipids and their impact on health status of obese subjects. Further, the role of diet and endogenous lipid synthesis in the development of serum lipid alterations is discussed, along with potential application of various lipid compounds as risk markers for obesity-related comorbidities.

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Section: Lipid Alterations In Obesitymentioning

confidence: 99%

Section: Lipid Alterations In Obesitymentioning

confidence: 99%

Section: Lipid Alterations In Obesitymentioning

confidence: 99%

Section: Lipid Alterations In Obesitymentioning

confidence: 99%

Section: Lipid Alterations In Obesitymentioning

confidence: 99%

See 3 more Smart Citations

Alterations of specific lipid groups in serum of obese humans: a review

Mika

Śledziński

2016

Obesity Reviews

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Involvement of Cytochrome P450 in Reactive Oxygen Species Formation and Cancer

Hrycay

Bandiera

2015

Advances in Pharmacology

169

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Molecular signatures of oxidative stress: relevance to clinic and research

et al. 2013

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study on the redox biology of health and disease has come of age. Redox imbalance also defined as redox stress constitutes one of the main cellular lesion associated with many types of pathologies including cardiometabolic, neurodegenerative, oncological, rheumatic and autoimmune diseases. Reactive species (either centered on oxygen or on nitrogen) can induce many damaging cellular processes, such as DNA oxidative lesions and loss of membrane integrity due to lipid peroxidation. Thus the evaluation of the redox imbalance of biological samples is extremely important in clinical practice as well as in research settings. This may constitute an important tool to evaluate the level of cellular lesions associated with specific pathological mechanisms, or the response to pharmacological and nonpharmacological treatment. The present review focuses on the molecular signatures of redox imbalance in various diseased processes.

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Trends in the Evaluation of Lipid Peroxidation Processes

Cited by 5 publications

References 88 publications

Alterations of specific lipid groups in serum of obese humans: a review

Alterations of specific lipid groups in serum of obese humans: a review

Involvement of Cytochrome P450 in Reactive Oxygen Species Formation and Cancer

Molecular signatures of oxidative stress: relevance to clinic and research

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