Acne is a common skin disorder that affects both adolescents and adults. Epidemiological data on acne is limited from developing countries. The objective of present study was to investigate the prevalence and epidemiology of Acne vulgaris in humans in Quetta through a standardized questionnaire, which was prepared under the supervision of authentic skin specialist. One thousand subjects were examined and information was recorded in the questionnaire. The data was analyzed by applying statistical analysis (Minitab, Crosstab, Pearson Chi Square test and Analysis of Variance. The results of present study determined the prevalence of Acne vulgaris according to different variables including Age (Teenage, Adult), Gender (Male, Female), Skin (Dry, Normal, Oily, Semi Oily) Menstrual (Pre-menstrual, post-menstrual), Marital status (Married, Unmarried) and Food (Normal, Spicy) were found statistically associated (P<0.05) with the prevalence of Acne vulgaris in study area. The Chi-square test analysis indicated that acne vulgaris prevalence was significantly higher in teenagers, female, oily skin, pre-menstrual, unmarried and the individuals who consume more spicy food (P<0.05). The present study determined the current status of Acne vulgaris with association of different risk factors in population of Quetta. This study will be very helpful for its control program in district Quetta, Balochistan, Pakistan.