Trends in the lifetime risk of COPD exacerbation requiring hospitalisation

Abstract

This study aimed to estimate time trends in the lifetime risk of hospitalisation with exacerbation of chronic obstructive pulmonary disease (COPD) in Denmark.During the period from 1994 to 2008, a register-based cohort study was conducted covering each subject in the entire population of Denmark (5.18 million in 2008). Based on previously validated diagnosis codes, all COPD hospitalisations were identified. Individual retrospective review periods of 8 years were used to determine first-time hospitalisations. From year 2002 to 2008, all first-time COPD hospitalised subjects aged o30 years were identified. The calculation of lifetime risk was based on age-and sex-specific first-time COPD hospitalisation rates and rates of COPD hospitalisation-free survival, assuming them to be calendar time stationary.The study included 23.9 million person-years of risk time and identified 48 959 first-time COPD hospitalisations. For 30-year-olds in Denmark, the lifetime risk of COPD hospitalisation was 12.0% (95% CI 11.9-12.2) for females and 10.9% (95% CI 10.8-11.1) for males. Trends were generally equal in both sexes.During the period from 2002 to 2008, the rate of first-time COPD hospitalisations decreased, while the survival of never COPD hospitalised subjects increased. In consequence, the lifetime risk of COPD hospitalisation remained constant. @ERSpublications A 10% lifetime risk of COPD hospitalisation remains constant

Lifetime risk of hospital diagnosed chronic obstructive pulmonary disease in remote Aboriginal people: a cohort study

“…In this cohort study, we found that one in two individuals in this remote community had hospital‐diagnosed COPD during their lifetime. The lifetime risk in this Aboriginal group is much higher than those previously reported in non‐Indigenous populations 8–11 . In Ontario, Canada, Gershon et al reported about one in four people in the general population will develop physician‐diagnosed COPD in their lifetime 8 .…”

“…In this study, we found that women had a higher lifetime risk of hospital diagnosed COPD than men. In studies in Canada and Netherlands, men had a slightly higher lifetime risk than women 8 while, in a Denmark study, women had slightly higher lifetime risk of COPD (Figure ) 11 . These differences can be partly explained by sex differences in the prevalence of smoking among different populations.…”

“…In another study in the Netherlands, Van Durme et al reported a 16% lifetime risk of developing COPD for women and 24% for men 10 . In a recent study in Denmark by Lykkegaard et al, 11 the lifetime risk of hospital‐diagnosed COPD was 12.0% for women and 10.9% for men. Compared to those reported lifetime risks, the lifetime risk in Aboriginal people in this study is much higher, as shown in Figure .…”

“…Lifetime risk estimates have been effectively used to increase public awareness of various chronic diseases 6,7 . The lifetime risk of developing COPD has been estimated in some non‐Indigenous populations in North America 8 as one in four individuals and in Europe as one in eight to 12 individuals 9–11 . It has been reported that the risk of COPD death was higher in Aboriginal than in the general Australians in the Northern Territory 12 .…”

Chronic obstructive pulmonary disease in Denmark: Age-period-cohort analysis of first-time hospitalisations and deaths 1994–2012

“…According to the only validation study [10] and in line with prior studies [6,11,12], hospitalisation with COPD was defined as any hospitalisation with either ICD-10 codes J41-44 as primary diagnosis or with J13e18 (pneumonia) or J96 (respiratory failure) as primary diagnosis combined with J41-44 as a secondary diagnosis. The individual health administrative data were linked with data from the Demographic Register regarding the patients' dates of birth, death, and migrations to or from Denmark.…”