Trends in the Management of Intracranial Vascular Malformations in the USA from 2000 to 2007

Abstract

Objective. To assess prevalence, clinical characteristics, trends in treatment pattern, and outcome in patients with intracranial vascular malformations (IVMs). Methods. Nationwide inpatient sample. Patients with the diagnosis of an IVM admitted to US hospitals from 2000 to 2007. Results. In 58,051 IVM-related admissions (detection rate 2.4/100,000 person-years; mean age 49 ± 17 years; 52% women) major diagnoses were intracranial hemorrhage (ICrH) in 15%, seizure 32%, ischemia 5%, and headache 9%. Procedures included surgery (13%), embolization (13%), radiation therapy (2%), aneurysm clipping (1%), and mechanical ventilation (6%). Ventilation and ICrH were associated with death (2%), whereas ventilation, ICrH, surgery, seizure, and ischemia were associated with unfavorable outcome (20%). IVM detection rate and hospital outcome remained stable over time, whereas mean age and comorbid diagnosis of cerebral ischemia increased (ICrH and seizure decreased). Conclusion. IVMs are infrequent and present in 1/6 patients with some form of ICrH. Overall, seizure is the dominant comorbid diagnosis (1/3 patients). IVMs are equally prevalent among race-ethnic groups and are increasingly detected later in life. The inpatient care of IVM patients results in death or discharge into specialized care in 1/5 patients.

Outcomes after intracerebral hemorrhage from arteriovenous malformations

“…Second, errors in misclassification resulting from our use of ICD-9-CM codes are also possible, but the ICD-9-CM code for ICH has been previously validated to have high specificity and positive predictive value. 12,13 While the code for AVM has been used in prior studies, 16,30 data on the sensitivity and specificity of the code are lacking. ICD-9-CM codes for major diagnoses in these types of administrative datasets have generally been shown to be reliable.…”