Trends in the Pattern of Leukaemia Incidence in a Tertiary Health Center in Nigeria: 1990-2004

Omoti, Caroline Edijana; Imiere, Edwin Olatunji

doi:10.4314/jmbr.v5i2.10692

Cited by 9 publications

(9 citation statements)

References 8 publications

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“…According to a previous study, leukaemia constitutes more than fifty-five percent of haematological malignancies. Leukaemia is classified into acute or chronic, which can be classified further into myeloid and lymphoid subtypes using morphological, cytochemical, immunologic, cytogenetic and molecular techniques [3,6,7]. Based on the above, leukaemia can be categorized as acute myeloid leukaemia (AML), acute lymphoblastic leukaemia (ALL), chronic myelogenous leukaemia (CML) and chronic lymphocytic leukaemia (CLL).…”

Section: Introductionmentioning

confidence: 99%

“…Based on the above, leukaemia can be categorized as acute myeloid leukaemia (AML), acute lymphoblastic leukaemia (ALL), chronic myelogenous leukaemia (CML) and chronic lymphocytic leukaemia (CLL). For appropriate treatment, these can be subtyped further [7,8]. Immunological, cytogenetic and molecular technologies have allowed classification of acute leukaemia into more subtypes, thereby improving the diagnosis and treatment of the disease.…”

Section: Introductionmentioning

confidence: 99%

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The Epidemiology of Leukaemia in Zimbabwe: A Ten Year Retrospective Study

Mandisodza¹

2017

HIJ

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Background: Haematological malignancies are defined as primary cancers of blood cells. Leukaemia constitutes more than fifty-five percent of haematological malignancies. The epidemiology of leukaemia in Zimbabwe is currently unknown. Aim: To investigate the incidence of leukaemia in Zimbabwe during a ten year period from 2004 to 2013. Objective: To understand the latest epidemiology of leukaemia in the country in order to effectively manage the disease and inform policy makers. Methods: A ten year cross sectional retrospective epidemiological study was carried out on 601 reported cases of leukaemia registered at the Zimbabwe National Cancer Registry from 1January 2004 to 31 December 2013. Results: More males (59%) had leukaemia than female (41%). Children (28%) developed leukaemia more than the adults. Chronic myelogenous leukaemia (29%) was the most common type of leukaemia, followed by acute myeloid leukaemia (24%), acute lymphoblastic leukaemia (18%), unclassified (17%) and chronic lymphocytic leukaemia (12%). Harare had the highest and Matebeleland South the lowest reported cases of leukaemia. Unemployed adults had the highest incidence followed by children. Conclusion: Zimbabwe has an increasing burden of the leukaemia compared to developed countries. A high proportion of leukaemia was not classified, making it difficult to come up with reliable subtypes of the disease. More men and children were affected than women and the elderly respectively. The distribution of types of leukaemia was consistent with literature information. Unemployed people appeared to have a higher risk for developing leukaemia in Zimbabwe.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Epidemiology of Leukaemia in Zimbabwe: A Ten Year Retrospective Study

Mandisodza¹

2017

HIJ

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“…Our findings highlight a generally equal representation of women and men during CLL diagnosis at TAH (Table 1). In contrast, more women than men have been shown to present with the disease in other African countries such as Zambia 26 and Nigeria, 4,20,27,28 whilst more men than women were reported in SA, 19 Morocco, 29 Zimbabwe and Malawi, 30 Senegal, 18 Kenya 31 and Algeria. 32 In addition, our observations differ from reports of developed countries where CLL occurrence is higher in men.…”

Section: Gender and Agementioning

confidence: 98%

Chronic lymphocytic leukaemia trends and features at a tertiary hospital in South Africa (2011–2016)

Musaigwa

Grewal

Abayomi

et al. 2021

South African Journal of Oncology

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Background: Chronic lymphocytic leukaemia (CLL) is a common lymphoproliferative disorder in developed countries. However, this condition is rare in Africa and there is a paucity of information on CLL, specifically on the continent.Aim: This study described, retrospectively, the frequency, demographics and laboratory features of CLL cases diagnosed from 2011 to 2016.Setting: Department of Pathology, National Health Laboratory Service, Tygerberg Academic Hospital, Cape Town.Methods: A retrospective analysis was performed for all CLL diagnoses made between 01 January 2011 and 31 December 2016.Results: Eighty CLL cases were diagnosed between 2011 and 2016. Men and women presented with the disease equally (48.8% vs. 51.2%, p 0.05). The mean age at diagnosis was 66.79 years (range of 37–95 years) and the modal age range (36.3%) was 60–69 years. Men presented with the disease at a significantly younger age than women (mean = 64 years vs. mean = 69.5 years, p 0.05). There were three (3.75%) human immunodeficiency virus (HIV)-positive patients (age range 43–50 years). Chromosome 13q14 deletion was found in 6 out of 19 patients (31.6%). Trisomy 12 and deletion 11q22 were found in 5 out of 21 (24%) and 7 out of 21 (33.3%) patients, respectively. Deletions 13q34 and 17p were negative for 6 and 20 patients, respectively.Conclusion: Chronic lymphocytic leukaemia at our facility presented equally in men and women. Men presented with the disease at a younger age than women. Additionally, our findings suggested that HIV is uncommon amongst CLL patients tested for HIV.

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“…[3,4] In a study done at University of Benin Teaching Hospital, Benin, to determine the pattern of leukemia incidence in Benin city, the incidence of ALL was found to be 10.3% of 253 cases of leukemia seen between 1990 and 2004 and showing increasing trend at 5 years intervals. [5] Similarly, in a preliminary report of a prospective study on the neoplastic diseases of the hematopoietic system carried out at University College Hospital Ibadan, 19.5% of the cancers were found to be ALL. [6] Accurate characterization of the lymphoid malignant cell requires not only morphology but also, immunologic, cytogenetic, and molecular diagnostic methods.…”

Section: Frequency and Clinical Impact Of Etv6/runx1 Af4-mll And Bcmentioning

confidence: 99%

Frequency and clinical impact of ETV6/RUNX1, AF4-MLL, and BCR/ABL fusion genes on features of acute lymphoblastic leukemia at presentation

et al. 2016

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Trends in the Pattern of Leukaemia Incidence in a Tertiary Health Center in Nigeria: 1990-2004

Cited by 9 publications

References 8 publications

The Epidemiology of Leukaemia in Zimbabwe: A Ten Year Retrospective Study

The Epidemiology of Leukaemia in Zimbabwe: A Ten Year Retrospective Study

Chronic lymphocytic leukaemia trends and features at a tertiary hospital in South Africa (2011–2016)

Frequency and clinical impact of ETV6/RUNX1, AF4-MLL, and BCR/ABL fusion genes on features of acute lymphoblastic leukemia at presentation

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