Trends in the surgical treatment of articular cartilage defects of the knee in the United States

Abstract

Cross-sectional study, Level IV.

Third‐generation autologous chondrocyte implantation versus mosaicplasty for knee cartilage injury: 2‐year randomized trial

“…Few studies have compared cartilage repair techniques. [12][13][14] Furthermore, wide variations in the assessment methods and patient populations hinder comparisons across studies. In contrast to our trial, a randomized controlled trial showed that first-generation ACI (n ¼ 58) was significantly better than mosaicplasty (n ¼ 42) after a mean follow-up of 19 months.…”

“…The mean O'Driscoll score was 15.1 AE 3.7 (range, [10][11][12][13][14][15][16][17][18][19] in the Cartipatch 1 group and 18.5 AE 2.5 (range, [14][15][16][17][18][19][20][21] in the mosaicplasty group, yielding a significant 3.3-point difference in favor of mosaicplasty (p ¼ 0.02). The O'Driscoll score was not significantly different between the groups with defects <3.5 cm 2 or !3.5 cm 2 (p ¼ 0.43 and p ¼ 0.28).…”

Geographic variation in fasciotomy during operative management of tibia fractures

“…A multitude of incidence and demographic studies of orthopedic injury have been used the PearlDiver database since 2010. [6][7][8][9][10][11][12][13][14][15][16][17] PearlDiver provided state totals of operatively managed tibia fractures and state totals of patients who have had both a lower extremity fasciotomy and an operatively managed tibia fracture from 2007 to 2011. State procedure volumes less than eleven were censored by PearlDiver to protect patient privacy.…”

A Road Map to Commercialization of Cartilage Therapy in the United States of America

“…In general, ACI has favorable reports of regeneration predominantly for a younger population (up to 40 years), 91,92 whereas chondroplasty and MF are more common and routinely performed with the older age groups (<40 years). 93 Most cellular products under the biologic designation employ MSCs from bone marrow, adipose tissue, or umbilical cord with a combination of material and/or PRP and are delivered as a patch or injection. 94,95 Notable among them are ASCs that are isolated from a patient's own fat pad, which can be processed by medium selection and seeded on a collagen dermal matrix with fibrin glue.…”