Trends in Tuberculosis Epidemiology among Children in the Democratic Republic of Congo

Aketi, Loukia; Joseph, Shiku Diayisu; Kashongwe, Zacharie; Gertrude, Lay; Kibadi, Kapay; Patrick, Kayembe Kalambay

doi:10.4236/jtr.2016.44026

Cited by 3 publications

(2 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similar results were reported in New-Zealand, showing an increase between 1992 and 2001 in childhood TB case notification(15) and in Congo, where a sharp rise in TB case notification number was observed from 1995 to 2014(3). Similarly, TB case notification of children aged 0-14 years increased from 13.4/100,000 in 2011 to about 17.2/100,000 in 2014 in Nigeria…”

supporting

confidence: 78%

See 1 more Smart Citation

The growing burden of childhood tuberculosis in Southern Tunisia: temporal trends across two decades: 1995-2016

et al. 2019

View full text Add to dashboard Cite

Background: In recent years, childhood tuberculosis (TB) has attracted global interest after a long period of neglect. We aimed to give an update about the epidemiological profile of childhood TB in south of Tunisia and to describe their chronological trends from 1995 to 2016. Methods: We retrospectively collected data of TB new cases in children aged <15 years between 1995 and 2016 in Southern Tunisia. Joinpoint Regression Analysis was performed to analyze chronological trends and annual percentage changes (APC) were estimated. Results: Overall, 204 cases of TB were noted in children. The average incidence rate of overall TB was 4.09/100000 population/year. There was a significant rise in extrapulmonary tuberculosis (EPTB) incidence (APC=2.76%; 95% confidence interval (95% CI)=[0.40-5.00]), while pulmonary tuberculosis PTB incidence rate showed a non-significant decrease over time. The under-fives had a significant growing trend (APC of 3.95%; 95% CI=[0.80-7.30]). We noted a significant upward trend of TB incidence in rural districts (APC=4.91%; 95% CI=[1.90-8.10]). Trends analysis by anatomical site indicated an increase in lymph node TB new cases (APC=5.26%; 95% CI=[2.80-7.80]). Conclusions: A significant rise in TB incidence rate was observed in TB cases, EPTB, notably lymph node, the under-fives and rural districts inhabitants. An increased focus on groups at high risk and implementing preventive strategies in this highly vulnerable population is warranted.

show abstract

supporting

confidence: 78%

“…The highest rates of TB were recorded in Southern Tunisia, where tuberculosis management is still challenging. This lack of knowledge could contribute to a poor control of TB among children, limiting advances to attain the "End TB" objectives (3).…”

Section: Introductionmentioning

confidence: 99%

The growing burden of childhood tuberculosis in Southern Tunisia: temporal trends across two decades: 1995-2016

et al. 2019

View full text Add to dashboard Cite

show abstract

Risk Factors Affecting Mortality in Children with Pulmonary Tuberculosis in Lubumbashi, Democratic Republic of the Congo

Mukuku¹

2017

JLPRR

View full text Add to dashboard Cite

Introduction: Childhood tuberculosis remains poorly understood and presents diagnostic and therapeutic challenges. The objective of this study was to describe the epidemiological, diagnostic and therapeutic aspects of childhood pulmonary tuberculosis in Lubumbashi in the DRC and to identify risk factors for mortality. Methods: This is a retrospective analytical study of the medical records of children (under 15 years of age) followed for pulmonary tuberculosis at the 22 centers' tuberculosis Diagnostic and Treatment during the period 1 January 2013 to 31 December 2015 in Lubumbashi. Results: 717 cases of pulmonary TB had been recorded during the study period. 377 were males and 340 were females. The mean age was 8.3 years (range: 6 months-14 years). The evolution was known for 674 children of whom 157 died (mortality rate 23.3%). In multivariate analysis, age ≤5 years (aOR=7.03 [4.36-11.35]), emaciation (aOR=2.95 [1.82-4.78]), HIV seropositivity (aOR=5.25 [3.20-8.62]), negativity by direct microscopy (aOR=2.04 [1.13-3.68]) and leukocytes ≥12000/mm3 (aOR=1.99 [1.28-3.09]) are independent predictors of mortality. Conclusion: TB is still a very severe disease with high mortality rates in children. Early recognition of infection associated with correct early treatment, systematic entourage investigation and chemoprophylaxis by isoniazide in all children under 5 years of age is essential for attempting to reduce these prognostic indices.

show abstract

Maternal Knowledge of Tuberculosis and Bacillus Calmette Guerin Vaccination in Pediatric Health Services in Kinshasa

Aketi¹,

Diayisu²,

Kashongwe³

et al. 2017

JTR

View full text Add to dashboard Cite

Introduction: To participate effectively in the fight against tuberculosis (TB), mothers need to have a good knowledge of TB and its prevention. The objective of this study was to evaluate the knowledge of mothers about TB and Bacillus Calmette Guérin (BCG). Methods: This was a cross-sectional survey performed from September to December 2015 in 4 health care facilities of Kinshasa. It concerned mothers of children who received BCG vaccine. The frequencies and chi-square of Pearson were used to report results. Results: A total of 380 couples of the children and their mothers were recruited. The median age of children was 16 months (ranges: 6 days to 59 months); 224 (58.9%) of them received BCG during the period recommended; 62 (16.3%) experienced a side effect. There was a significant association (p = 0.00) between sides effects and the delayed vaccination. The average age of the mothers was 29.3 ± 6.4 years; 352 (92.6%) had heard about TB; 28 (7.4%) never heard about it; 168 (44.2%) knew that TB is a contagious disease; only 111 (29.2%) knew the mode of transmission; 87 (22.9%) did not know any signs of TB, and 54 (14.2%) knew about prevention with the BCG vaccine. Factors significantly associated with the mothers' lack of knowledge were a low level of education (p = 0.01), young age (p = 0.02), and place of residence (p = 0.04). Conclusion: There is an urgent need to improve the education of the population, particularly those who lives in poor conditions and who are uneducated.

show abstract

Trends in Tuberculosis Epidemiology among Children in the Democratic Republic of Congo

Cited by 3 publications

References 26 publications

The growing burden of childhood tuberculosis in Southern Tunisia: temporal trends across two decades: 1995-2016

The growing burden of childhood tuberculosis in Southern Tunisia: temporal trends across two decades: 1995-2016

Risk Factors Affecting Mortality in Children with Pulmonary Tuberculosis in Lubumbashi, Democratic Republic of the Congo

Maternal Knowledge of Tuberculosis and Bacillus Calmette Guerin Vaccination in Pediatric Health Services in Kinshasa

Contact Info

Product

Resources

About