Trends in Type of Original Psoriasis Publications by Decade, 1960 to 2010

Abstract

Context:Research investigating psoriasis has spanned decades, and as our understanding of the disease has evolved, the focus of publications has changed.Objective: We sought to characterize the trends in original psoriasis-related research from 1960 to 2010 chronologically by decade.Methods: A literature review was performed using the keyword psoriasis in the MED-LINE database. All original psoriasis-related articles published at the beginning of each decade were searched and categorized by study type and topic.Main Outcome Measure: Number of articles per topic.Results: A total of 869 original psoriasis-related articles were found. The number of publications increased 18 fold over 5 decades. The immunology and pathogenesis of psoriasis was the most frequently researched topic (36%), and retrospective studies were the most common study type (37%). Recent highly published topics included biologic therapy, genetics, and psoriasis-associated cardiovascular disease.Conclusion: Original psoriasis-related publications have grown substantially since 1960. Basic science research into the immunology and pathogenesis has been and continues to be the mainstay of psoriasis research. Recent research trends suggest the focus has expanded to topics such as psoriasis-associated cardiovascular disease, genetics, and biologic therapy. INTRODUCTIONPsoriasis is a chronic inflammatory skin condition affecting 2% of the population, and it can be physically and psychologically debilitating.1 Although psoriasis was first described in 1841, it was the 1960s that first saw a surge in psoriasis-related research. Initial studies focused on the keratinocyte, and nonmalignant proliferation and reduced differentiation were found to be hallmarks of psoriasis. Since then, considerable achievements have changed the way psoriasis is viewed. Advances in technology have allowed researchers to gain an understanding of the molecular mechanisms driving the disease. Breakthroughs in biologic therapy have revolutionized the way psoriasis is managed. Recent research suggests that patients with psoriasis have a systemic inflammatory state, putting them at increased risk of cardiovascular complications, including metabolic syndrome, peripheral vascular disease, stroke, myocardial infarction, and cardiac death.3,4 Some articles suggest that tumor necrosis factor inhibitors may decrease the risk of stroke and myocardial infarction in patients with psoriasis. 5,6 As understanding of the disease has continued to evolve over five decades, research interests have expanded. Our goal is to identify these new components to gain a better understanding of the current landscape and future direction of psoriasis-related research. On the basis of recent study findings, we hypothesized that there would be a higher proportion of recent publications investigating psoriasis-associated cardiovascular disease and biologic therapy. To our knowledge, no study has systematically examined research trends in this field. We sought to accomplish this through a literature rev...

Psoriasis: A bibliometric analysis in the Arab World (2004–2019)

“…The difficulty of Arab countries in catching up with psoriasis research can be related to the trends being oriented towards genetics and biologic therapy in psoriasis; publications in immunology and pathogenesis of psoriasis grew quickly between 1960 and 1990 with a rise of 488% and then continued to grow steadily with a growth of 66% more articles in 2010 as compared to 1990 20 . Immunological and genetic studies are conducted in advanced laboratories and need significant financial support, whereas in Arab countries, only 0.15% of the GDP is spent on research and development, which is well below the world average of 1.4% 21 .…”

Publication trends in hidradenitis suppurativa from 2008 to 2018

“…5 Following cyclosporine's observed clinical benefit in the 1970s, basic science publications on psoriasis immunopathogenesis exploded. 6,7 Further, a dramatic shift in literature from phototherapy to biologics occurred following anti-TNF medication's observed efficacy, laying the foundation for psoriasis' current understanding of pathogenesis.…”

Bibliometric analysis and description of research trends on T cells in psoriasis over the past two decades (2003–2022)

“…Additionally, we found that bibliometric analyzes of psoriasis articles from different periods concluded that biologic treatments were the focus of research. This can be attributed to the dual critical roles that T cells play in psoriasis, serving as both contributors to the disease's pathogenesis and potential targets for therapeutic intervention [ [12] , [13] , [14] ]. Herein, a bibliometric analysis was conducted to assess research on T cells in psoriasis; we systematically analyzed research content, development trends, and noteworthy achievements regarding T cells in psoriasis over the past 20 years and identified potential directions for future research.…”