Trends in use and outcome of newborn infants treated with high frequency ventilation in Australia and New Zealand, 1996–2003

Tingay, David G.; Mills, John F.; Morley, Colin J; Pellicano, Anastasia; Dargaville, Peter A.

doi:10.1111/j.1440-1754.2007.01036.x

Cited by 27 publications

(18 citation statements)

References 23 publications

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“…However, the disposable income of an urban resident was 11,691 (nationwide, 13,786) CNY, whereas the annual net income of a rural resident was only 4,293 CNY [13] . Our data show that the median hospital cost of NRF is nearly as much as the total annual income of a rural family in Hebei in 2007 (8,418 vs. 8,586 CNY, respectively). Because of a lack of health insurance, and high in-hospital costs in both urban and rural settings, health care services are often unaffordable.…”

Section: Mortalitymentioning

confidence: 87%

“…In this emerging province, surfactant use in RDS increased from an overall pan-China level of 36.0% in 2004 [2] to 58.3% in 2007 in Hebei. Surfactant was used mainly for rescue purposes as was initially used in Western countries in the 1980s-1990s [8,9] . RDS remains the leading cause for support in neonates with BWs 6 2,500 g, yet only 17.1% of them received surfactant treatment in the study, which calls for a further regional-based study of live births to identify the independently related factors.…”

Section: Respiratory Therapies and Primary Diagnosesmentioning

confidence: 99%

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Mortality of Neonatal Respiratory Failure Related to Socioeconomic Factors in Hebei Province of China

Liu²,

Wang³

et al. 2010

Neonatology

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Dramatic progress has occurred in neonatal intensive care in tertiary centers in mid-eastern China. We investigated the characteristics of neonatal respiratory failure (NRF) including the incidence, management, outcomes and costs in 14 neonatal intensive care units (NICUs) of Hebei, a province at an intermediate economic level in China. Over a period of 12 consecutive months in 2007–2008, perinatal data were collected prospectively from all NICU admissions (n = 11,100). NRF was defined as severe hypoxemia requiring respiratory support for more than 24 h, and was diagnosed in 1,875 newborns (16.9%). The average birth weight of newborns with NRF was 2,200 g (range 600–5,500 g), with 60.9% <2,500 g, and 2% <1,000 g. The male:female ratio was 2.6:1. The leading diagnosis was respiratory distress syndrome; 58.3% of newborns with respiratory distress syndrome received surfactant. Continuous positive airway pressure was used more than ventilation (73.3 vs. 49.1%,p < 0.001). Overall, the mortality rate until discharge was 31.4% (583/1,859). Most deaths (432, 74.1%) followed a parental decision to withdraw care. NRF mortality varied in association with different gross domestic product levels, family annual income and nurse-to-bed ratios. The median cost of a hospital stay was 10,169 CNY (interquartile range: 6,745–16,386) for NRF survivors. We conclude that, despite the available respiratory support in these emerging NICUs, the mortality of NRF remains. This was associated with prematurity, standard of care but also with socioeconomic factors affecting treatment decisions. Assessment of efficacy of respiratory support for NRF in such emerging neonatal services should account for both standard of care and socioeconomic conditions.

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Section: Mortalitymentioning

confidence: 87%

Section: Respiratory Therapies and Primary Diagnosesmentioning

confidence: 99%

Mortality of Neonatal Respiratory Failure Related to Socioeconomic Factors in Hebei Province of China

Liu²,

Wang³

et al. 2010

Neonatology

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“…Published series from large neonatal databases suggest that 20%-30% of all infants requiring intubation and ventilation with MAS are treated with high-frequency ventilation. 55 High frequency oscillatory ventilation is the more commonly used mode, especially in those with significant atelectasis, where application of higher mean airway pressures (around 25 cm) with recruitment maneuvers at moderate frequency (6-8 Hz) has been found to be beneficial. 54 It also lends a clinical advantage in MAS with associated severe PPHN, as the response to inhaled NO is better with HFOV than conventional ventilation, with recent evidence suggesting failure of this combination and requirement of ECMO in only 5% of such babies.…”

Section: High-frequency Ventilationmentioning

confidence: 99%

Meconium aspiration syndrome: challenges and solutions

Goel¹,

Nangia²

2017

RRN

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Meconium aspiration syndrome (MAS) is an important cause of morbidity and mortality among term newborns. A result of antepartum or postpartum aspiration of meconium stained amniotic fluid (MSAF), MAS causes respiratory distress of varying severity, often complicated by air leaks or persistent pulmonary hypertension (PPHN). There has been a tremendous change in the concepts of pathophysiology and management of MAS over the last few decades. Routine endotracheal suctioning is no longer recommended in both vigorous and nonvigorous neonates with MSAF. Supportive management, along with newer therapies such as surfactant, inhaled nitric oxide, and high-frequency ventilation, has resulted in marked improvement in the overall outcome of MAS. The present review highlights the challenges in understanding the complex pathophysiology and optimal management approach to MAS. Potential future therapies and drugs in trial are also discussed briefly.

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“…Many affected newborn infants require mechanical ventilation through an endotracheal tube (ETT) 1 2. The presence of an ETT inhibits the infant’s intrinsic ability to remove endogenous lung secretions, and thus regular suctioning of the ETT is required 3…”

mentioning

confidence: 99%

Lung volume and cardiorespiratory changes during open and closed endotracheal suction in ventilated newborn infants

Hoellering

Copnell

Dargaville

et al. 2008

Archives of Disease in Childhood - Fetal and Neonatal Edition

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Trends in use and outcome of newborn infants treated with high frequency ventilation in Australia and New Zealand, 1996–2003

Abstract: HFV is an established mode of neonatal ventilation in Australia and New Zealand. HFV is being applied to infants at the greatest risk of serious adverse outcomes, most likely as a rescue therapy.

Cited by 27 publications

References 23 publications

Mortality of Neonatal Respiratory Failure Related to Socioeconomic Factors in Hebei Province of China

Mortality of Neonatal Respiratory Failure Related to Socioeconomic Factors in Hebei Province of China

Meconium aspiration syndrome: challenges and solutions

Lung volume and cardiorespiratory changes during open and closed endotracheal suction in ventilated newborn infants

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