Trends of Chitosan Based Delivery Systems in Neuroregeneration and Functional Recovery in Spinal Cord Injuries

Kurakula, Mallesh; Gorityala, Shashank; Patel, Dipal; Basim, Pratap; Patel, Bhaumik B.; Jha, Saurabh

doi:10.3390/polysaccharides2020031

Cited by 13 publications

(8 citation statements)

References 137 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hydrogels based on CHT are gaining considerable interest for biomedical applications due to its biocompatibility, biodegradability, non-toxicity, and biological features, such as bio-adhesiveness, antibacterial, hemostatic, and anti-inflammatory properties. Altogether, these properties are pivotal in the design of biomedical systems for smart drug delivery [ 127 , 128 , 129 , 130 , 131 , 132 , 133 , 134 , 135 ], wound healing [ 136 ], and regenerative medicine [ 137 ].…”

Section: Chitosan-based Hydrogels For Biomedical Applicationsmentioning

confidence: 99%

Chitosan-Based Biomaterials: Insights into Chemistry, Properties, Devices, and Their Biomedical Applications

et al. 2023

View full text Add to dashboard Cite

Chitosan is a marine-origin polysaccharide obtained from the deacetylation of chitin, the main component of crustaceans’ exoskeleton, and the second most abundant in nature. Although this biopolymer has received limited attention for several decades right after its discovery, since the new millennium chitosan has emerged owing to its physicochemical, structural and biological properties, multifunctionalities and applications in several sectors. This review aims at providing an overview of chitosan properties, chemical functionalization, and the innovative biomaterials obtained thereof. Firstly, the chemical functionalization of chitosan backbone in the amino and hydroxyl groups will be addressed. Then, the review will focus on the bottom-up strategies to process a wide array of chitosan-based biomaterials. In particular, the preparation of chitosan-based hydrogels, organic–inorganic hybrids, layer-by-layer assemblies, (bio)inks and their use in the biomedical field will be covered aiming to elucidate and inspire the community to keep on exploring the unique features and properties imparted by chitosan to develop advanced biomedical devices. Given the wide body of literature that has appeared in past years, this review is far from being exhaustive. Selected works in the last 10 years will be considered.

show abstract

Section: Chitosan-based Hydrogels For Biomedical Applicationsmentioning

confidence: 99%

Chitosan-Based Biomaterials: Insights into Chemistry, Properties, Devices, and Their Biomedical Applications

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Many studies have been conducted to find a biomaterial suitable for cardiac tissue engineering, and chitosan has proven to be one of the polymers that can be successfully used in cardiac tissue regeneration procedures. The main reason is that chitosan possesses properties similar to glycosaminoglycans that are widely distributed throughout the connective tissue, making it an ideal candidate for tissue repair [ 126 ]. Different types of chitosan have been used in cardiac tissue regeneration, specifically scaffolds, injectable hydrogels, and stem cell delivery using chitosan hydrogels as a platform [ 127 ].…”

Section: Cardiac and Nervous Tissuesmentioning

confidence: 99%

Chitosan-Based Biomaterials for Tissue Regeneration

et al. 2023

View full text Add to dashboard Cite

Chitosan is a chitin-derived biopolymer that has shown great potential for tissue regeneration and controlled drug delivery. It has numerous qualities that make it attractive for biomedical applications such as biocompatibility, low toxicity, broad-spectrum antimicrobial activity, and many others. Importantly, chitosan can be fabricated into a variety of structures including nanoparticles, scaffolds, hydrogels, and membranes, which can be tailored to deliver a desirable outcome. Composite chitosan-based biomaterials have been demonstrated to stimulate in vivo regeneration and the repair of various tissues and organs, including but not limited to, bone, cartilage, dental, skin, nerve, cardiac, and other tissues. Specifically, de novo tissue formation, resident stem cell differentiation, and extracellular matrix reconstruction were observed in multiple preclinical models of different tissue injuries upon treatment with chitosan-based formulations. Moreover, chitosan structures have been proven to be efficient carriers for medications, genes, and bioactive compounds since they can maintain the sustained release of these therapeutics. In this review, we discuss the most recently published applications of chitosan-based biomaterials for different tissue and organ regeneration as well as the delivery of various therapeutics.

show abstract

“…Hence the combination of hydrogels with nanoparticles (NPs) has given rise to a new study area in tissue engineering and regenerative medicine. The role of metal nanoparticles has been extensively investigated in SCI treatment using experimental modeling ranging from metals like gold, iron, and silver or their compounds, such as oxides . In addition, metal nanoparticles are one of the most appealing nanomaterials to be utilized in a biological system due to their resistance to corrosion and oxidation, high surface volume ratio, and good surface chemistry and functionalization .…”

Section: Conductive Hydrogel As a Scaffold For Sci Repairmentioning

confidence: 99%

Application of Conductive Hydrogels on Spinal Cord Injury Repair: A Review

Shahemi

Mahat

Asri

et al. 2023

ACS Biomater. Sci. Eng.

View full text Add to dashboard Cite

Spinal cord injury (SCI) causes severe motor or sensory damage that leads to long-term disabilities due to disruption of electrical conduction in neuronal pathways. Despite current clinical therapies being used to limit the propagation of cell or tissue damage, the need for neuroregenerative therapies remains. Conductive hydrogels have been considered a promising neuroregenerative therapy due to their ability to provide a pro-regenerative microenvironment and flexible structure, which conforms to a complex SCI lesion. Furthermore, their conductivity can be utilized for noninvasive electrical signaling in dictating neuronal cell behavior. However, the ability of hydrogels to guide directional axon growth to reach the distal end for complete nerve reconnection remains a critical challenge. In this Review, we highlight recent advances in conductive hydrogels, including the incorporation of conductive materials, fabrication techniques, and cross-linking interactions. We also discuss important characteristics for designing conductive hydrogels for directional growth and regenerative therapy. We propose insights into electrical conductivity properties in a hydrogel that could be implemented as guidance for directional cell growth for SCI applications. Specifically, we highlight the practical implications of recent findings in the field, including the potential for conductive hydrogels to be used in clinical applications. We conclude that conductive hydrogels are a promising neuroregenerative therapy for SCI and that further research is needed to optimize their design and application.

show abstract

Trends of Chitosan Based Delivery Systems in Neuroregeneration and Functional Recovery in Spinal Cord Injuries

Cited by 13 publications

References 137 publications

Chitosan-Based Biomaterials: Insights into Chemistry, Properties, Devices, and Their Biomedical Applications

Chitosan-Based Biomaterials: Insights into Chemistry, Properties, Devices, and Their Biomedical Applications

Chitosan-Based Biomaterials for Tissue Regeneration

Application of Conductive Hydrogels on Spinal Cord Injury Repair: A Review

Contact Info

Product

Resources

About