Trends of Colorectal Cancer Epidemiology and Morphology in Tehran Metropolis, Iran from 2006 to 2015

Abstract

Objectives: This study aimed at reporting a 10-years trend in epidemiology and morphology of colorectal cancer (CRC) in Tehran Metropolis, using the data of the National Cancer Registry. Methods: The main sources for data collection included pathology, clinical/paraclinical, as well as death registries. The quality assessment of data was performed based on standard protocols and international reference. Age-standardized incidence rates (ASR) per 100 000 were reported at province levels. Results: Totally, 16280 patients with CRC, who were diagnosed from 2006 to 2015 in Tehran Metropolis, were enrolled in the study; 56.86% of cases were male. The ASRs of adenocarcinoma and other morphology types were higher in males than females. The highest and lowest overall ASR (95% confidence interval (CI)) were reported in 2013 and 2006 with the value of 22.46 (95% CI: 21.58 - 23.35) and 5.55 (95% CI: 5.04 - 6.07) per 100 000 person-years, respectively. The average annual percentage change (AAPC) indicated that from 2006 to 2015, the overall ASR had a statistically upward trend with the value of 15.0 (95% CI: 1.80 - 30.00) in total CRC patients. Besides, the AAPC of adenocarcinoma type in males and females was 15.6 (95% CI: 1.10-32.20) and 12.9 (95% CI: 0.60 - 26.60) over the study period, respectively, which showed a significant upward trend. The ASR was much higher in age ≥ 50 years old compared to age < 50 years old. Conclusions: The results showed a growing trend in registry coverage in Tehran Province. Tehran is a high-risk area for the incidence of CRC. Cancer control programs need to be adjusted based on the status of cancer incidence in Tehran Province.

Determinants of survival and recurrence in patients with stage I colorectal cancer

“…Colorectal cancer (CRC) is the third most common cancer and the second cause of cancer-related death worldwide ( 1 ), with an increasing trend of incidence, especially in countries with low to medium human development indices ( 2 ). Recent national cancer registry reports in Iran indicate CRC as the third most common cancer ( 3 ), previously the fourth, with an increasing trend in its incidence, attributed to the growing use of screening programs and Western lifestyles ( 4 , 5 ). Recent advances in cancer screening programs and novel management strategies have resulted in an overall reduced mortality of CRC ( 6 ).…”

Differences in Clinicopathological Features, P16Ink4a and P57KIP2 Immunohistochemical Expressions, and Survival Between Colorectal Carcinoma in Rectosigmoid and Other Colonic Locations

“…The rectal-sigmoid (i.e., rectosigmoid) CRC incidence exceeds 50% of CRC cases in some epidemiological studies [ 5 , 6 ]. The rectosigmoid location for cancers has recently gained more focus for investigation due to its therapeutic and prognostic challenges [ 7 , 8 ].…”