Trends of HIV/Syphilis/HSV-2 seropositive rate and factors associated with HSV-2 infection in men who have sex with men in Shenzhen, China: A retrospective study

Mao, Shasha; Feng, Shuidong; Zheng, Chenli; Hu, Wei; Li, Hao; Tang, Jie; Yang, Zheng; Zhao, Jin

doi:10.1371/journal.pone.0251929

Cited by 3 publications

(5 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Integration of the NSCP program contributed to a significant decrease in the prevalence of syphilis among high-risk populations, with syphilis prevalence decreasing from 13.4 to 3.8% among MSM and from 3.8 to 1.7% among FSW from 2010 to 2020. Similar decreasing trends in syphilis prevalence were also observed among various populations in multiple provinces in China (29)(30)(31)(32). Known factors contributing to STI prevalence among high-risk populations include inconsistent condom use (33), low STI-related knowledge (27,28), and having multiple and casual sex partners (34).…”

Section: Discussionsupporting

confidence: 70%

Evaluating the effect of the plan of national syphilis control in controlling the syphilis epidemic in Jiangsu, China 2010–2020

Shi,

Chen,

Liu

et al. 2023

Front. Public Health

View full text Add to dashboard Cite

BackgroundStarting in 2010, the Chinese government initiated a 10-year syphilis control plan, called the national syphilis control plan (NSCP), to address the emerging threat of syphilis. We aimed to evaluate the effect of the NSCP plan on syphilis control in Jiangsu, China.MethodsThe temporal trends of syphilis incidence, prevalence and rate of condom use were estimated by Joinpoint regression with average annual percent change (APC) and average annual percentage (APPC). A Chi-square test was conducted to analyze the outcomes in different subgroups. ArcGIS was used to analyze the spatiotemporal distribution of syphilis incidence.ResultsGeographically, early and congenital syphilis incidence decreased significantly in all areas of the province during the period of NSCP. Early syphilis incidence decreased from 21.1 to 8.8 (APC: −7.5, 95%CI: −8.6, −6.5, p < 0.001) per 100,000 people, and congenital syphilis decreased from 63.6 to 4.1 (APC: −14.8, 95%CI: −20.8, −8.4, p < 0.01) per 100,000 newborns from 2010 to 2020. Also, syphilis prevalence reduced from 13.4 to 3.8% (APC: −8.7, 95%CI: −12.1, −5.0, p = 0.001) among men who have sex with men, from 5.3 to 1.7% (APC: −7.9, 95%CI: −11.7, −3.8, p = 0.002) among female sex workers and remained under 1.0% with slight variations among pregnant women (APC: 0.3, 95%CI: −4.3, 5.1, p = 0.877) from 2010 to 2020. 0.2% (2,436) of pregnant women who received free syphilis testing during pregnancy were diagnosed with current syphilis infection, and 97.0% (2,555) of newborns in the province were delivered to women diagnosed with syphilis. 91.8% (2,346) of live babies and about 90% of diagnosed patients received complete standard syphilis diagnosis and treatment services.ConclusionTrends of early syphilis incidence and syphilis prevalence show a considerable decreasing trend among almost all the key populations after implementing NSCP. Congenital syphilis has significantly decreased as well and hence, the NSCP program should be sustained and strengthened to control the syphilis epidemic in China further.

show abstract

Section: Discussionsupporting

confidence: 70%

Evaluating the effect of the plan of national syphilis control in controlling the syphilis epidemic in Jiangsu, China 2010–2020

Shi,

Chen,

Liu

et al. 2023

Front. Public Health

View full text Add to dashboard Cite

show abstract

“…A retrospective study in Shenzhen, China found that ever had sex with female, gender of the first sexual partner, marital status, age group, education, monthly income (RMB), frequency of condom use in anal sex with men in the past 6 months, and history of STIs were significantly associated with herpes simplex virus type 2 (HSV-2 infection). This study also indicated that MSM who used a condom every time in anal sex with a man in the past 6 months were less likely to be infected with HSV-2 than MSM who never used a condom [ 28 ]. A systematic review and meta-analysis reported that higher HPV prevalence was observed among MSM with less education and HIV-positive status in China [ 29 ].…”

Section: Text Of Reviewmentioning

confidence: 99%

Advances and challenges in sexually transmitted infections prevention among men who have sex with men in Asia

Chen

Niu

2022

Current Opinion in Infectious Diseases

View full text Add to dashboard Cite

Purpose of review This review summarizes recently published research on sexually transmitted infections (STIs) and sexually transmitted diseases (STDs) among men who have sex with men (MSM) in Asia, covering four main areas: prevalence and consequences of STIs/STDs, factors associated with STI risk, strategies and measures of STI prevention, challenges in the prevention of SITs. Recent findings Studies show that STIs among Asian MSM are still prevalent, with the prevalence of STIs varying slightly from country to country. In addition to the number of sexual partners, frequency of condom use, high-risk sexual behaviors, the influence of Confucianism, law, and COVID-19 are also related to STI risk. Social stigma, weak health systems, lack of funding and policy support are the current challenges for STIs prevention. Summary In the future, new media technologies are encouraged to be used to enhance education and reduce stigma and discrimination against MSM and STIs. Expanding STI screening, strengthening STI knowledge propaganda and education among MSM population, and providing necessary counseling and medical services are main strategies in STI prevention. It is also important to strengthen STI awareness and policy support at the national level.

show abstract

“…a ) Eastern China [ 25 , 26 , 28 , 31 , 33 , 36 , 37 , 39 , 40 , 49 , 51 , 52 ] 0.016 − 0.124 to 0.155 0.825 Southwest China [ 10 , 32 , 43 , 45 , 50 ] 0.047 − 0.111 to 0.204 0.562 Southern China [ 9 , 29 , 34 , 38 , 41 ] 0.007 − 0.151 to 0.165 0.932 Northeast China [ 30 , 48 ] − 0.023 − 0.222 to 0.177 0.824 Northern China [ 35 ] − 0.068 − 0.315 to 0.179 0.590 Northwest China [ 46 ] − 0.08 − 0.332 to 0.172 0.533 Multi-region [ 27 , 47 ] 0.046 − 0.149 to 0.241 0.644 Study period 2000–2010 [ 10 , …”

Section: Meta-regression Test Publication Bias and Sensitivity Analysismentioning

confidence: 99%

“… 2011–2020 [ 9 , 25 – 27 , 30 , 33 , 36 , 37 , 40 − 44 , 49 − 51 ] − 0.037 − 0.117 to 0.043 0.367 Mixed [ 28 , 35 , 46 , 48 ] 0.019 − 0.137 to 0.099 0.755 Sampling procedure Multiple [ 24 , 25 , 27 , 29 , 34 – 36 , 43 , 49 , 51 , 52 ](Ref.) Snowball [ 10 , 32 , 37 , 38 , 42 , 45 – 47 ] − 0.028 − 0.118 to 0.063 0.546 Venue-based [ 26 , 31 , 39 ] 0.028 − 0.103 to 0.158 0.679 Respondent-driven [ 28 , 44 , 50 ] − 0.028 …”

Section: Meta-regression Test Publication Bias and Sensitivity Analysismentioning

confidence: 99%

“… Snowball [ 10 , 32 , 37 , 38 , 42 , 45 – 47 ] − 0.028 − 0.118 to 0.063 0.546 Venue-based [ 26 , 31 , 39 ] 0.028 − 0.103 to 0.158 0.679 Respondent-driven [ 28 , 44 , 50 ] − 0.028 − 0.153 to 0.098 0.667 VCT [ 30 , 33 , 40 ] − 0.152 − 0.282 to − 0.022 0.022 Time-location sampling [ 9 ] 0.074 − 0.125 to 0.272 0.467 STD clinic [ 41 , 48 ] − 0.049 − 0.198 to 0.099 0.512 Study design Cohort [ 38 , 46 , 51 ](Ref.) Cross-sectional [ 9 , 10 , 24 − 37 , 39 – 45 , 47 − 50 , 52 …”

Section: Meta-regression Test Publication Bias and Sensitivity Analysismentioning

confidence: 99%

See 1 more Smart Citation

Prevalence of herpes simplex virus 2 among MSM in Mainland China: a systematic review and meta-synthesis

2022

View full text Add to dashboard Cite

Background As one of the most prolific sexually transmitted infections (STIs) in the world, Herpes Simplex Virus Type 2 (HSV-2) is one of the primary causes of genital ulcers. In addition, HSV-2 infection multiplies the risk of acquiring HIV. Men who have sex with men (MSM) are at particularly high risk of contracting both diseases. Unfortunately, little information is available with regarding to the comprehensive prevalence of HSV-2 among MSM in mainland China. The objective of this manuscript was to determine the composite prevalence of HSV-2 among MSM in mainland China via systematic review and meta-synthesis. Methods We systematically searched PubMed, Embase, Chinese National Knowledge Infrastructure, WanFang Database for Chinese Periodicals, and the VIP Database for Chinese Technical Periodicals for relevant articles published from the database’s inception to 28 April 2022 that reported data on the prevalence of HSV-2 within the MSM population in mainland China. We considered publications to be eligible for inclusion if they satisfied these conditions: (1) publication participants were MSM in China mainland. Studies were excluded if participants were exclusively all HIV-positive MSM, all HIV-negative MSM, injection-drug users, or MSM sex workers. These studies would have introduced selection bias and skewed pooled prevalence estimates higher or lower; (2) proportion of HSV-2 virus among MSM in China mainland were reported; (3) HSV-2 diagnosis was conducted in a laboratory based on a strict type-specific glycoprotein-G based assays diagnostic method or PCR method; and (4) had a sample size over 20. Exclusion criteria included: (1) not being an original manuscript, such as a review article; (2) being a guideline, correspondence, and/or conference abstract; (3) the publication population did not reside in China mainland when the study was carried out; and (4) if the same epidemiological data were printed in both English and Chinese journals, English articles were preferred. We assessed the risk of bias in each individual publication using the modified quality assessment tool for systematic reviews of observational publications (QATSO). This meta-analysis was conducted by using R software. Due to extensive heterogeneity between various publications, we employed a random effect model to calculate the composite prevalence and corresponding 95% confidence intervals. We then conducted meta-regression to investigate the potential causes of observed heterogeneity. Lastly, we employed subgroup analysis based on characteristics of studies to compare the prevalence estimates across the groups. Publication bias was evaluated by funnel plot, Begg’s test and Egger’s test. Sensitivity analysis was also performed by removing each single study separately. Results This study included 31 articles (9 published in English and 22 in Chinese) in our meta-synthesis. The pooled prevalence of HSV-2 among MSM in China mainland was 0.094 (95%CI:0.074 to 0.116). Prevalence of HSV-2 among MSM in Southwest China was higher than other regions, prevalence of HSV-2 among MSM that recruited from VCT (Voluntary Counseling and Testing) was lower than other ways, respectively. Compared to 2000–2010, the prevalence of HSV-2 among MSM in mainland China showed a downward trend during 2011–2020, however, the difference was not statistically significant . Conclusion Prevalence of HSV-2 among MSM in China mainland is high, around 0.094. It indicated HSV-2 needed to be screening for MSM population among China mainland and proper actions should be taken to curve the trend of HSV-2 among MSM in China. Trial registration CRD42020180361.

show abstract

Trends of HIV/Syphilis/HSV-2 seropositive rate and factors associated with HSV-2 infection in men who have sex with men in Shenzhen, China: A retrospective study

Cited by 3 publications

References 32 publications

Evaluating the effect of the plan of national syphilis control in controlling the syphilis epidemic in Jiangsu, China 2010–2020

Evaluating the effect of the plan of national syphilis control in controlling the syphilis epidemic in Jiangsu, China 2010–2020

Advances and challenges in sexually transmitted infections prevention among men who have sex with men in Asia

Prevalence of herpes simplex virus 2 among MSM in Mainland China: a systematic review and meta-synthesis

Contact Info

Product

Resources

About