Background: Hospital acquired infections are still a health care problem across many countries. However, the implementation of the required and recommended infection control practices is unsatisfactory. Methods: This was a 6-month cross-sectional study in five regions' private hospitals in Saudi Arabia. Results: All the hospitals' infection control practices were below 75%. Administrators, doctors, nurses, and allied medical staff's were of practicing infection control varied across the five hospitals. Only the doctors and allied medical staff responded with more "yes" than "no" to infection control practice questions. Conclusion: The infection control program and practices in private hospitals in Saudi Arabia are still demanding. Unless these practices are improved across private-sector hospitals, the prevalence and burden of hospital acquired infections will remain in place.