Trexit

Yuwono, Arianto; Salada, Rolando; Tan, Teck Wei

doi:10.4103/aja.aja_24_21

Cited by 6 publications

(5 citation statements)

References 9 publications

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“…28,29 Through the provision of training and resources, the initiative successfully converted all prostate biopsies performed in the Alliance from TRB to TPB in March 2019, 29 and as shown by Yuwono et al, this project is replicable in other parts of the world. 30 Moreover, increasing data demonstrate that TPB is well-tolerated under local anesthesia and is characterized by a moderate learning curve, good reproducibility and a superior cancer detection rate, even with the free-hand technique. 31,32 In light of this, it is probably time to abandon TRB.…”

Section: Discussionmentioning

confidence: 99%

Infection Rate after Transperineal Prostate Biopsy with and without Prophylactic Antibiotics: Results from a Systematic Review and Meta-Analysis of Comparative Studies

et al. 2022

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Purpose: We performed a systematic review comparing the incidence of infectious complications following transperineal ultrasound-guided prostate biopsy (TPB) in cases utilizing antibiotic prophylaxis (AP) vs cases not utilizing antibiotic prophylaxis (NAP). Materials and Methods: The incidences of complications were pooled using the Cochran-Mantel-Haenszel method with the random effect model and expressed as risk ratio (RR). RR higher than 1 indicates an increased risk of complication in patients undergoing TPB without antibiotics. Statistical significance was set at p <0.05 and 95% CI. Results: A total of 1,748 papers were retrieved. After the screening process, 8 studies were included in the quantitative analysis (4 retrospective, and 4 prospective and nonrandomized), reporting on 3,662 patients. A total of 2,368 patients underwent TPB utilizing AP and 1,294 underwent TPB utilizing NAP. The pooled rates of post-biopsy fever from 6 available studies reporting this parameter were 0.69% in the AP group and 0.47% in the NAP group (RR: 1.02, 95% CI: 0.02e44.55, p[0.99). The pooled rates of post-biopsy genitourinary infections from 8 available studies reporting this parameter were 0.11% in the AP group and 0.31% in the NAP group (RR: 2.09, 95% CI: 0.54e8.10, p[0.29). The pooled rates of post-biopsy sepsis over 8 studies reporting this parameter were 0.13% in the AP group and 0.09% in the NAP group (RR: 1.09, 95% CI: 0.21e5.61, p[0.92). The pooled rates of post-biopsy readmission for infections over 8 studies reporting this parameter were 0.13% in the AP group and 0.23% in the NAP group (RR: 1.29, 95% CI: 0.31e5.29, p[0.73). Death due to post-biopsy sepsis did not occur in any study. Conclusions: This systematic review found no significant difference in infection rate, fever, sepsis or readmission rate after TPB between those cases utilizing AP and those cases without AP.

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Section: Discussionmentioning

confidence: 99%

Infection Rate after Transperineal Prostate Biopsy with and without Prophylactic Antibiotics: Results from a Systematic Review and Meta-Analysis of Comparative Studies

et al. 2022

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“…This achieves fewer number of systematic cores which can range from 18 to 24 cores using the transperineal approach. 22 The 2021 European Association of Urology Guidelines do recommend 10–12 core biopsies for transrectal biopsy and stated that >12 cores have not been shown to be significantly more conclusive. 23 – 25…”

Section: Discussionmentioning

confidence: 99%

Can we omit systematic biopsies in patients undergoing MRI fusion-targeted prostate biopsies?

Leow

Koh

Chow

et al. 2022

Asian Journal of Andrology

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Magnetic resonance imaging (MRI)-targeted prostate biopsy is the recommended investigation in men with suspicious lesion(s) on MRI. The role of concurrent systematic in addition to targeted biopsies is currently unclear. Using our prospectively maintained database, we identified men with at least one Prostate Imaging-Reporting and Data System (PI-RADS) ≥3 lesion who underwent targeted and/or systematic biopsies from May 2016 to May 2020. Clinically significant prostate cancer (csPCa) was defined as any Gleason grade group ≥2 cancer. Of 545 patients who underwent MRI fusion-targeted biopsy, 222 (40.7%) were biopsy naïve, 247 (45.3%) had previous prostate biopsy(s), and 76 (13.9%) had known prostate cancer undergoing active surveillance. Prostate cancer was more commonly found in biopsy-naïve men (63.5%) and those on active surveillance (68.4%) compared to those who had previous biopsies (35.2%; both P < 0.001). Systematic biopsies provided an incremental 10.4% detection of csPCa among biopsy-naïve patients, versus an incremental 2.4% among those who had prior negative biopsies. Multivariable regression found age (odds ratio [OR] = 1.03, P = 0.03), prostate-specific antigen (PSA) density ≥0.15 ng ml −2 (OR = 3.24, P < 0.001), prostate health index (PHI) ≥35 (OR = 2.43, P = 0.006), higher PI-RADS score (vs PI-RADS 3; OR = 4.59 for PI-RADS 4, and OR = 9.91 for PI-RADS 5; both P < 0.001) and target lesion volume-to-prostate volume ratio ≥0.10 (OR = 5.26, P = 0.013) were significantly associated with csPCa detection on targeted biopsy. In conclusion, for men undergoing MRI fusion-targeted prostate biopsies, systematic biopsies should not be omitted given its incremental value to targeted biopsies alone. The factors such as PSA density ≥0.15 ng ml −2 , PHI ≥35, higher PI-RADS score, and target lesion volume-to-prostate volume ratio ≥0.10 can help identify men at higher risk of csPCa.

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“…Peris R. Castaneda , 1 Michael Ahdoot, 1 and Charles J. Rosser To the Editor: We read with interest the publication by Zattoni et al 1 This paper adds to the growing number of large, retrospective cohort studies in prostate cancer (PCa) diagnostic practice. [2][3][4][5][6] However, this and other reports of transperineal biopsy vs transrectal biopsy represent either nonrandomized studies or single-/ multi-institutional observations of local anesthetic transperineal (LATP) prostate biopsy alone, which do not fully inform whether clinical centers should switch from transrectal ultrasound-guided (TRUS) prostate biopsy to LATP in the diagnostic setting. Guideline and policy makers await evidence from randomized clinical trials to inform practice.…”

mentioning

confidence: 91%

Repeat Transurethral Resection of Muscle-invasive Bladder Cancer Prior to Radical Cystectomy Is Prognostic but Not Therapeutic. Letter.

2023

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Trexit

Cited by 6 publications

References 9 publications

Infection Rate after Transperineal Prostate Biopsy with and without Prophylactic Antibiotics: Results from a Systematic Review and Meta-Analysis of Comparative Studies

Infection Rate after Transperineal Prostate Biopsy with and without Prophylactic Antibiotics: Results from a Systematic Review and Meta-Analysis of Comparative Studies

Can we omit systematic biopsies in patients undergoing MRI fusion-targeted prostate biopsies?

Repeat Transurethral Resection of Muscle-invasive Bladder Cancer Prior to Radical Cystectomy Is Prognostic but Not Therapeutic. Letter.

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