TRIAC disrupts cerebral thyroid hormone action via negative feedback and heterogenous distribution among organs

Yamauchi, Ichiro; Hakata, Takuro; Ueda, Yohei; Sugawa, Taku; Omagari, Ryo; Teramoto, Yasuo; Nakayama, Shoji F.; Nakajima, Daisuke; Kubo, Takuya; Inagaki, Nobuya

doi:10.1016/j.isci.2023.107135

Cited by 4 publications

(2 citation statements)

References 45 publications

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“…It is also very interesting compound as the substance that cannot pass through the brain barrier in animal experiments. 41 As TRIAC is slightly smaller than AcT4, we anticipated that TRIAC shows different recognition ability from AcT4. Based on the composition in Table S1, † we also evaluated 9G-MIP-TRIAC particles by HPLC.…”

Section: Resultsmentioning

confidence: 94%

Enhanced molecular recognition with longer chain crosslinkers in molecularly imprinted polymers for an efficient separation of TR active substances

Kubo,

Yagishita,

Tanigawa

et al. 2024

RSC Adv.

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Section: Resultsmentioning

confidence: 94%

Enhanced molecular recognition with longer chain crosslinkers in molecularly imprinted polymers for an efficient separation of TR active substances

Kubo,

Yagishita,

Tanigawa

et al. 2024

RSC Adv.

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“…The hypothyroidism group consisted of a random sample of 100 consecutive recruited patients. The diagnosis of hypothyroidism was confirmed according to the criteria published by the American Thyroid Association (11) and the hormonal diagnosis was based on a detection kit through ELISA with a thyroid panel (free T4 and TSH) from the commercial house MONOBIND INC which has been validated internationally (12). Patients older than 65 years were included since the cardiovascular risk equations used have not been validated in younger patients.…”

Section: Populationmentioning

confidence: 99%

Description of the Metabolic Syndrome and Its Individualized Risk in a Latin American Cohort of Geriatric Patients With Hypothyroidism

Dulcey Sarmiento,

Theran Leon,

Gomez

et al. 2023

Preprint

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Introduction : It is still discussed whether hypothyroidism as an independent risk factor for cardiovascular events . Our objective was to evaluate the association between hypothyroidism and the risks of cardiovascular events and mortality through 3 stratification systems . Methods : A retrospective study was carried out by reviewing medical records in the period of January 2015 - December 2017 in a South American hospital. Patients had fasting total cholesterol , high-density lipoprotein (HDL) cholesterol , triglycerides and plasma glucose were included . Quantitative variables are presented as mean ± standard deviation or median ( interquartile range ) according to their distribution, and qualitative variables as percentages . Student's test was performed to assess the differences between two variables. all statistical analyzes of the database results were performed with (SPSS for Windows, v.20.1; Chicago, IL). Results: The present study has demonstrated metabolic syndrome criteria present in patients diagnosed with hypothyroidism in a high proportion. The male gender was 32% compared to the female 68%. The Framingham equation classified a higher percentage of women patients with hypothyroidism as low cardiovascular risk compared to the PROCAM and SCORE equations. Item was found that there was a greater cardiovascular risk in those patients with still uncontrolled hypothyroidism profile, showing a statistical correlation of this alteration for the 3 stratification systems used. Conclusions: Hypothyroidism is a risk factor for cardiovascular disease . Uncontrolled hypothyroidism in the present study is associated with greater adverse outcomes in the medium and long term, the present study warns about the need to better characterize this patient cohorts .

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Transcriptomic landscape of hyperthyroidism in mice overexpressing thyroid-Stimulating hormone

Yamauchi,

Sugawa,

Hakata

et al. 2025

iScience

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TRIAC disrupts cerebral thyroid hormone action via negative feedback and heterogenous distribution among organs

Cited by 4 publications

References 45 publications

Enhanced molecular recognition with longer chain crosslinkers in molecularly imprinted polymers for an efficient separation of TR active substances

Enhanced molecular recognition with longer chain crosslinkers in molecularly imprinted polymers for an efficient separation of TR active substances

Description of the Metabolic Syndrome and Its Individualized Risk in a Latin American Cohort of Geriatric Patients With Hypothyroidism

Transcriptomic landscape of hyperthyroidism in mice overexpressing thyroid-Stimulating hormone

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