Triacylglycerol-rich lipoproteins derived from healthy donors fed different olive oils modulate cytokine secretion and cyclooxygenase-2 expression in macrophages: the potential role of oleanolic acid

Graham, V.; Wheeler‐Jones, Caroline P.D.; Perona, Javier S.; Ruı́z-Gutı́errez, Valentina; Botham, Kathleen M.

doi:10.1007/s00394-011-0215-2

Cited by 17 publications

(14 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This inhibitory effect was exerted by modulating inducible NO synthase gene expression []. In the human monocyte cell line, THP‐1, incubated with triacylglycerol‐rich lipoproteins of subjects with high OA intake, there was a decrease in the secretion of monocyte chemoattractant protein‐1, which was associated with a decrease in cyclooxygenase‐2 gene expression []. Likewise, analogues of OA were powerful inhibitors of cellular inflammatory processes such as the induction of NO synthase and cyclooxygenase 2 by IFN‐γ [] or release of phospholipase A 2 [].…”

Section: Role Of Minor Voo Components In Atherosclerosis Developmentmentioning

confidence: 99%

Efficacy of bioactive compounds from extra virgin olive oil to modulate atherosclerosis development

Lou-Bonafonte

Arnal

Navarro

et al. 2012

Molecular Nutrition Food Res

View full text Add to dashboard Cite

As olive oil is the main source of calories in the Mediterranean diet, a great deal of research has been devoted to characterizing its role in atherosclerosis. Virgin olive oil is an oily matrix that contains hydrocarbons, mainly squalene; triterpenes such as uvaol, erythrodiol, oleanolic, and maslinic acid; phytosterols; and a wide range of phenolic compounds comprising simple phenols, flavonoids, secoiridoids, and lignans. In this review, we analyze the studies dealing with atherosclerosis and olive oil in several species. A protective role of virgin olive oil against atherosclerosis has been shown in ApoE‐deficient mice and hamsters. In the former animal, sex, dose, and dietary cholesterol are modulators of the outcome. Contradictory findings have been reported for rabbits, a circumstance that could be due to the profusion of experimental designs, differing in terms of doses and animal strains, as well as sources of olive oils. This role has yet to be fully validated in humans. Minor components of olive oil have been shown to be involved in atherosclerosis protection. Nevertheless, evidence of the potential of isolated compounds or the right combination of them to achieve the antiatherosclerotic effect of virgin olive oil is inconclusive and will undoubtedly require further experimental support.

show abstract

Section: Role Of Minor Voo Components In Atherosclerosis Developmentmentioning

confidence: 99%

Efficacy of bioactive compounds from extra virgin olive oil to modulate atherosclerosis development

Lou-Bonafonte

Arnal

Navarro

et al. 2012

Molecular Nutrition Food Res

View full text Add to dashboard Cite

show abstract

“…In rabbits, administration of hydroxytyrosol at 4 mg/kg body weight in the presence of saturated fat and cholesterol reduced the size of atherosclerotic lesions when compared to animals receiving this diet without hydroxytyrosol (Gonzalez‐Santiago, Martin‐Bautista, Carrero, & Fonolla, 2006). Similarly, many earlier studies reported that consumption of OO, VOO, EVOO, and their bioactive compounds prevented from atherosclerosis (Buus et al., 2011; Graham et al., 2012; Lou‐Bonafonte, Arnal, Navarro, & Osada., 2012; Murie‐Fernandez et al., 2011; Zrelli, Matsuoka, Kitazaki, Zarrouk, & Miyazaki, 2011).…”

Section: Op and Atherosclerosismentioning

confidence: 54%

A review on management of cardiovascular diseases by olive polyphenols

Mehmood

Usman

Patil

et al. 2020

Food Science & Nutrition

View full text Add to dashboard Cite

Noncommunicable diseases have increasingly grown the cause of morbidities and mortalities worldwide. Among them, cardiovascular diseases (CVDs) continue to be the major contributor to deaths. CVDs are common in the urban community population due to the substandard living conditions, which have a significant impact on the healthcare system, and over 23 million human beings are anticipated to suffer from the CVDs before 2030. At the moment, CVD physicians are immediately advancing both primary and secondary prevention modalities in high‐risk populations. The cornerstone of CVD prevention is a healthy lifestyle that is more cost‐effective than the treatments after disease onset. In fact, in the present scenario, comprehensive research conducted on food plant components is potentially efficacious in reducing some highly prevalent CVD risk factors, such as hypercholesterolemia, hypertension, and atherosclerosis. Polyphenols of olive oil (OO), virgin olive oil (VOO), and extra virgin olive oil contribute an essential role for the management of CVDs. Olive oil induces cardioprotective effects due to the presence of a plethora of polyphenolic compounds, for example, oleuropein (OL), tyrosol, and hydroxytyrosol. The present study examines the bioavailability and absorption of major olive bioactive compounds, for instance, oleacein, oleocanthal, OL, and tyrosol. This review also elucidates the snobbish connection of olive polyphenols (OP) and the potential mechanism involved in combating various CVD results taken up from the in vitro and in vivo studies, such as animal and human model studies.

show abstract

“…The traditional Mediterranean diet, characterized by the consumption of foods such as grapes, wine, must, raisins, olives and virgin olive oil, has been associated with a low incidence of cancer [ 41 ]. Previously, it has been described that oleanolic acid and palmitic acid possess cardioprotective effects [ 42 , 43 ], anti-inflammatory effects [ 44 ], and antiproliferative effects in highly invasive cancer cells and induce apoptosis in a wide variety of tumor cells including human prostate cancer cells [ 45 ], hepatocellular carcinoma cells [ 46 ], human pancreatic cells [ 47 ], liver cancer, lung cancer, osteosarcoma cells, human leukemia cells, human melanoma cells and colon cancer cells, among others [ 48 ].…”

Section: Discussionmentioning

confidence: 99%

Metabolomic profile in pancreatic cancer patients: a consensus-based approach to identify highly discriminating metabolites

et al. 2016

View full text Add to dashboard Cite

Purposepancreatic adenocarcinoma is the fourth leading cause of cancer related deaths due to its aggressive behavior and poor clinical outcome. There is a considerable variability in the frequency of serum tumor markers in cancer' patients. We performed a metabolomics screening in patients diagnosed with pancreatic cancer.Experimental DesignTwo targeted metabolomic assays were conducted on 40 serum samples of patients diagnosed with pancreatic cancer and 40 healthy controls. Multivariate methods and classification trees were performed.Materials and MethodsSparse partial least squares discriminant analysis (SPLS-DA) was used to reduce the high dimensionality of a pancreatic cancer metabolomic dataset, differentiating between pancreatic cancer (PC) patients and healthy subjects. Using Random Forest analysis palmitic acid, 1,2-dioleoyl-sn-glycero-3-phospho-rac-glycerol, lanosterol, lignoceric acid, 1-monooleoyl-rac-glycerol, cholesterol 5α,6α epoxide, erucic acid and taurolithocholic acid (T-LCA), oleoyl-L-carnitine, oleanolic acid were identified among 206 metabolites as highly discriminating between disease states. Comparison between Receiver Operating Characteristic (ROC) curves for palmitic acid and CA 19-9 showed that the area under the ROC curve (AUC) of palmitic acid (AUC=1.000; 95% confidence interval) is significantly higher than CA 19-9 (AUC=0.963; 95% confidence interval: 0.896-1.000).ConclusionMass spectrometry-based metabolomic profiling of sera from pancreatic cancer patients and normal subjects showed significant alterations in the profiles of the metabolome of PC patients as compared to controls. These findings offer an information-rich matrix for discovering novel candidate biomarkers with diagnostic or prognostic potentials.

show abstract

Triacylglycerol-rich lipoproteins derived from healthy donors fed different olive oils modulate cytokine secretion and cyclooxygenase-2 expression in macrophages: the potential role of oleanolic acid

Abstract: These findings demonstrate that TRLs derived from olive oil influence inflammatory processes in macrophages and suggest that oleanolic acid may have beneficial effects.

Cited by 17 publications

References 51 publications

Efficacy of bioactive compounds from extra virgin olive oil to modulate atherosclerosis development

Efficacy of bioactive compounds from extra virgin olive oil to modulate atherosclerosis development

A review on management of cardiovascular diseases by olive polyphenols

Metabolomic profile in pancreatic cancer patients: a consensus-based approach to identify highly discriminating metabolites

Contact Info

Product

Resources

About