Trial of Electrolyzed Strong Acid Aqueous Solution Lavage in the Treatment of Peritonitis and Intraperitoneal Abscess

Inoué, Yoshihiro; Endo, Shunsuke; Kondo, Koryo; Ito, Hironobu; Omori, Hiroaki; Saito, Kazuyoshi

doi:10.1111/j.1525-1594.1997.tb00695.x

Cited by 31 publications

(15 citation statements)

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“…In cases of peritonitis, partially with peritoneal abscess ( n = 7), no bacterial growth was detectable 3-7 days after irrigating twice daily for 9-12 days [149]. Postoperative complications including SSI were significantly reduced in patients with peritonitis without symptoms of intolerance [150].…”

Section: Sodium Hypochlorite/hypochlorous Acidmentioning

confidence: 99%

Consensus on Wound Antisepsis: Update 2018

Krämer

Dissemond²,

Kim³

et al. 2017

Skin Pharmacol Physiol

256

215

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Wound antisepsis has undergone a renaissance due to the introduction of highly effective wound-compatible antimicrobial agents and the spread of multidrug-resistant organisms (MDROs). However, a strict indication must be set for the application of these agents. An infected or critically colonized wound must be treated antiseptically. In addition, systemic antibiotic therapy is required in case the infection spreads. If applied preventively, the Wounds-at-Risk Score allows an assessment of the risk for infection and thus appropriateness of the indication. The content of this updated consensus recommendation still largely consists of discussing properties of octenidine dihydrochloride (OCT), polihexanide, and iodophores. The evaluations of hypochlorite, taurolidine, and silver ions have been updated. For critically colonized and infected chronic wounds as well as for burns, polihexanide is classified as the active agent of choice. The combination 0.1% OCT/phenoxyethanol (PE) solution is suitable for acute, contaminated, and traumatic wounds, including MRSA-colonized wounds due to its deep action. For chronic wounds, preparations with 0.05% OCT are preferable. For bite, stab/puncture, and gunshot wounds, polyvinylpyrrolidone (PVP)-iodine is the first choice, while polihexanide and hypochlorite are superior to PVP-iodine for the treatment of contaminated acute and chronic wounds. For the decolonization of wounds colonized or infected with MDROs, the combination of OCT/PE is preferred. For peritoneal rinsing or rinsing of other cavities with a lack of drainage potential as well as the risk of central nervous system exposure, hypochlorite is the superior active agent. Silver-sulfadiazine is classified as dispensable, while dyes, organic mercury compounds, and hydrogen peroxide alone are classified as obsolete. As promising prospects, acetic acid, the combination of negative pressure wound therapy with the instillation of antiseptics (NPWTi), and cold atmospheric plasma are also subjects of this assessment.

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Section: Sodium Hypochlorite/hypochlorous Acidmentioning

confidence: 99%

Consensus on Wound Antisepsis: Update 2018

Krämer

Dissemond²,

Kim³

et al. 2017

Skin Pharmacol Physiol

256

215

View full text Add to dashboard Cite

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“…Its usefulness was further extended in Japan after several studies used ES to manage mediastinitis after cardiac operations and peritoneal abscess after abdominal operations [15,16]. The ES has been found to promote re-epithelialization, increasing the proliferation of lymphocytes and macrophages associated with collagen deposition for surgical incision healing [14].…”

Section: Discussionmentioning

confidence: 99%

Electrolyzed Saline Irrigation for Elimination of Bacterial Colonization in the Empyema Space

Nakamoto¹,

Takeshige²,

Fujii³

et al. 2016

Surgical Infections

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Background: The empyema space is refractory to elimination of bacterial colonization. Electrolyzed saline (ES) was used as intra-pleural irrigation for rapid disinfection of the empyema space.Patients and Methods: Twenty consecutive patients with para-pneumonic empyema were reviewed in this study from 2007 to 2015. The empyema space was irrigated by miniaturized thoracoscopic surgery (mini VATS), and the efficacy and safety of the use of ES were evaluated.Results: Sixteen patients were male and four were female, with a mean age of 66.5 ± 9.5 y (27–90 y). Bacterial cultures of the purulent effusions from all 20 patients had positive results. Seventeen patients subsequently underwent continuous catheter irrigation and drainage. No patient had chest pain during ES irrigation. Fever duration after mini VATS was 2.8 ± 1.8 d (0–5 d). Catheter indwelling time was 10.3 ± 7.2 d (3–33 d). Inflammatory markers significantly improved (p < 0.05) within a week after mini VATS. Eighteen patients achieved pleural disinfection, and two patients had residual pathogens, one of whom later died of lung abscess. Space closure was successful in 14 patients. No patient underwent subsequent open drainage. Nineteen (95%) patients were discharged from the hospital. This treatment was successful in 18 (90%) patients, and one (5.6%) patient experienced recurrence.Conclusions: The ES irrigation facilitates the rapid disinfection and closure of the empyema space.

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“…Interestingly, there are some reports showing beneficial effects of super-oxidized solutions in disorders related to mast cell activation, suggesting that these solutions might have a direct modulator activity on this type of cells [20][21][22].…”

Section: Introductionmentioning

confidence: 96%

“…Similarly in humans, skin infections and ulcers [26], inflammatory skin disorders (e.g. pemphigus, psoriasis) [27], burns [28] and peritonitis [20,29] have all improved their outcomes with the use of SOS treatment. But whether these better outcomes are related to the antiseptic efficacy of the SOS, or to a synergystic anti-inflammatory effect, is unknown [29,30].…”

Section: Introductionmentioning

confidence: 99%