Trial of Normobaric and Hyperbaric Oxygen for Acute Carbon Monoxide Intoxication

Part 12: Cardiac Arrest in Special Situations

“…Other studies found no difference in neurologically intact survival. 376,377 A systematic review 378,379 and a recent evidence-based clinical policy review 380 concluded that, based on the available evidence, improvement in neurologically intact survival following treatment for carbon monoxide poisoning with hyperbaric oxygen is possible but unproven.…”

Part 8: Advanced Life Support

“…However, 2 studies found no difference in neurologically intact survival (LOE 5). 574,575 Two systematic reviews concluded that improvement in neurologically intact survival following the administration of hyperbaric oxygen to carbon monoxide poisoning patients was possible but unproven (LOE 5). 576,577 Two studies demonstrated that patients with carbon monoxide toxicity treated with hyperbaric oxygen who developed myocardial infarction have an increased risk of cardiovascular and all-cause mortality lasting at least 7 years after the event (LOE 5).…”

Should hyperbaric oxygen be used for carbon monoxide poisoning?

“…Figure 1 shows key outcomes, stratified by time after exposure. [1][2][3][4][5]7 Results that used neuropsychological tests to determine the presence of neurologic sequelae showed no effect over a 12-month course. Results that used clinical findings showed no effect after 6 weeks.…”