Trial of Pentoxifylline for Diabetic Impotence

Georgitis, William J.; Merenich, John A.

doi:10.2337/diacare.18.3.345

Cited by 6 publications

(3 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Under the established search strategy, we found 202 non-repeated records. After the screening and eligibility evaluation, three studies demonstrating the role of PTX oral administration in male infertility and its impact on sperm parameters and eight studies on males with ED were included in the narrative analysis (Micic et al, 1988;Korenman and Viosca, 1993;Georgitis and Merenich, 1995;Knoll et al, 1996;Peşkircioğlu et al, 1996;Ozdal et al, 2008;Safarinejad, 2011;Zahran et al, 2012;Kumar et al, 2015;Nasimi Doost Azgomi et al, 2018;Law et al, 2020) (shown in Figure 1).…”

Section: Literature Selectionmentioning

confidence: 99%

“…Five of them reported the single-use of PTX in erectile function (Georgitis and Merenich, 1995;Knoll et al, 1996;Korenman and Viosca, 1993;Peşkircioğlu et al, 1996;Zahran et al, 2012), three (60.00%) indicated improvement in erectile function through objective assessment after using PTX (Knoll et al, 1996;Korenman and Viosca, 1993;Peşkircioğlu et al, 1996) (Table 4). Korenman et al conducted a small RCT to evaluate the role of PTX in treating vascular ED.…”

Section: Pentoxifylline In the Treatment Of Edmentioning

confidence: 99%

“…By measuring patients' reports, partners' verification, and penile-brachial pressure index, they found PTX can be a well-tolerated alternative treatment for mild-to-moderate vascular ED (Korenman and Viosca, 1993). Although Georgitis et al concluded that pentoxifylline is not an effective treatment for diabetic ED through results from objectively measured percent rigidity, they indeed reported eight patients (among 34 individuals) were benefited from PTX administration (Georgitis and Merenich, 1995). Subsequently, Zahran and his colleagues investigated the efficacy of PTX in treating ED patients after receiving a T-shunt procedure and reported that PTX had no significant effect on the recovery of erectile function after severe ischemic injury (Zahran et al, 2012).…”

Section: Pentoxifylline In the Treatment Of Edmentioning

confidence: 99%

See 2 more Smart Citations

Treatment of Poor Sperm Quality and Erectile Dysfunction With Oral Pentoxifylline: A Systematic Review

Lü

Zhang

et al. 2022

Front. Pharmacol.

View full text Add to dashboard Cite

Background: Pentoxifylline (PTX) is a member of methylxanthine chemicals and a type of non-selective phosphodiesterase-5 inhibitors, which has been used in male infertility treatment to improve sperm quality and erectile dysfunction (ED) treatment. Mutually tight associations existed between ED and male infertility. Using PTX might kill two birds with one stone by improving sperm quality and erectile function in infertile men with ED.Methods: PubMed, Cochrane Library, EMBASE, and Web of Science were searched by October 2021. Based on available evidence from observational studies and randomized-controlled trials (RCTs), we conducted a systematic review to summarize the efficacy and safety of PTX in treating ED and male infertility. The protocol of the article was registered and updated in PROSPERO (CRD42021291396).Results: From 202 records, eight studies (7 RCTs) evaluating the role of PTX in ED and three studies (2 RCTs) assessing the efficacy of PTX in male infertility were included in the systematic review. Three studies (100.00%) and two studies (100.00%) reported the beneficial role of PTX in improving sperm progressive motility and normal sperm morphology rate, respectively. In contrast, only one study (33.33%) indicated the favorable role of PTX in enhancing sperm concentration. As for ED, three (60.00%) studies supported the treatment role of PTX alone in ED, and two studies (66.67%) favored the combination use of PTX and selective PDE5Is compared with selective PDE5Is alone. Safety analysis showed that PTX was a well-tolerated drug in ED and male infertility treatment.Conclusion: Given the association between ED and male infertility and satisfying findings from available evidence, PTX administration for the simultaneous treatment of poor sperm quality and mild ED in infertile men will highly enhance the treatment compliance. However, the finding should be treated carefully until validated by further studies.

show abstract