When prostate cancer is diagnosed at an early stage, the survival rate is high with the effect of the treatment methods applied. However, because its treatment is a long and difficult process, patients experience many problems. Although nursing interventions are important in the management of these problems, there are few studies in this area. The aim of this study is to summarize the literature on the effect of nurseled interventions on patient outcomes in patients with prostate cancer. The literature review was conducted within the framework of the PRISMA guidelines and PICO. In the study, international studies published between 2005 and 2021 in Medline/ PubMed, Cochrane, Web of Science, Proquest and Scopus databases and accessible with the keywords "nurse-led interventions, prostate cancer, patient outcomes" were reviewed. As a result of the review of 56 studies, four articles that met the inclusion criteria were included in the study. Nurse-led practices in patients with prostate cancer are as follows: nurse-led psycho-educational intervention, nurse-led group and one individual consultation and nurse-led algorithm-based treatment. It was determined that these interventions made by the nurse were effective on health-related quality of life, emotional and psychological symptoms, anxiety, depressive symptoms and cancer-related anxieties. Evidence for nurse-led interventions in prostate cancer patients is limited. More randomized controlled studies are needed to eliminate the lack of knowledge on this subject and to create quality evidence for practice. Individual nurse-led interventions are more beneficial in patients with prostate cancer.