Trial of vitamin A supplementation in very low birth weight infants at risk for bronchopulmonary dysplasia

Pearson, Ellyn; Bose, Carl; Snidow, T.; Ransom, Laurence; Young, Thomas E.; Bose, Gennie; Stiles, Alan D.

doi:10.1016/s0022-3476(05)81800-1

Cited by 138 publications

(58 citation statements)

References 15 publications

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“…Deficiency of vitamin A has been associated with the development of BPD (21,36,37), and clinical trials have demonstrated that vitamin A supplementation of infants with decreased vitamin A stores may reduce the risk for developing BPD (20). Because retinoids may stimulate antioxidant defenses (38) and act as antioxidants (39), they may protect the lung from damage by oxygen free radicals generated through direct oxygen exposure and by inflammatory cells.…”

Section: Discussionmentioning

confidence: 99%

Effects of Retinoic Acid on Airspace Development and Lung Collagen in Hyperoxia-Exposed Newborn Rats

2000

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Section: Discussionmentioning

confidence: 99%

Effects of Retinoic Acid on Airspace Development and Lung Collagen in Hyperoxia-Exposed Newborn Rats

2000

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“…In trials of vitamin A supplementation, reduced need for supplemental oxygen and mechanical ventilation was observed (113), but whether the incidence of BPD was reduced remains controversial with either no change (114) or slight decrease (115). As regards direct administration of RA, only experimental approaches in the hyperoxic rat model have been performed.…”

Section: Alveolar Formation Is Antagonistically Influenced By Ra and Gcmentioning

confidence: 99%

Control Mechanisms of Lung Alveolar Development and Their Disorders in Bronchopulmonary Dysplasia

et al. 2005

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“…[10][11][12][13] Parenteral supplemental vitamin A to decrease BPD is used at many institutions. 14 Recently, calorically dense products, with an increased protein-to-energy ratio, have become available for fluid-restricted infants.…”

Section: Introductionmentioning

confidence: 99%

Nutritional strategies and growth in extremely low birth weight infants with bronchopulmonary dysplasia over the past 10 years

et al. 2011

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Objective: Changes in nutritional strategies over the past decade have been shown to improve postnatal growth in extremely low birth weight (ELBW) infants. We showed 10 years ago that the majority of these ELBW infants with bronchopulmonary dysplasia (BPD) suffer postnatal growth failure. We theorized that recent changes in nutritional support strategies would positively affect growth outcomes in ELBW infants with BPD.Study Design: A retrospective study of 88 ELBW infants with BPD. Nutritional data, postnatal growth and BPD severity were compared across three cohorts: (1) weight gain p14 g kg À1 per day, (2) 14.1 to 16 g kg À1 per day and (3) X16 g kg À1 per day from return to birth weight through discharge. We also compared these to a historical cohort.Result: In all, 73% of current subjects grew at or above fetal rates. There was less extrauterine growth restriction (EUGR) by weight and head circumference for those ELBW infants with BPD receiving higher amounts of protein. Aggressive early TPN and receipt of caloric-dense milk seemed to be the 'new' nutritional strategies improving growth for current ELBW infants with BPD compared with those 10 years ago.Conclusion: Despite a diagnosis of BPD, improved nutritional strategies have enhanced postnatal growth in infants at high risk for EUGR.

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Trial of vitamin A supplementation in very low birth weight infants at risk for bronchopulmonary dysplasia

Cited by 138 publications

References 15 publications

Effects of Retinoic Acid on Airspace Development and Lung Collagen in Hyperoxia-Exposed Newborn Rats

Effects of Retinoic Acid on Airspace Development and Lung Collagen in Hyperoxia-Exposed Newborn Rats

Control Mechanisms of Lung Alveolar Development and Their Disorders in Bronchopulmonary Dysplasia

Nutritional strategies and growth in extremely low birth weight infants with bronchopulmonary dysplasia over the past 10 years

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