Trial of Vitamin D Supplementation in Infants with Bronchiolitis: A Randomized, Double-Blind, Placebo-Controlled Study

Saad, Khaled; AzizNafisa, H R Abd; Elhoufey, Amira; El-Asheer, Osama M.; Salim, Mohamed; AhmedAhmed, E; BaseerKhaled, A Abdel; DarwishManal, M

doi:10.1089/ped.2015.0492

Cited by 15 publications

(23 citation statements)

References 22 publications

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“…In present study, the mean hospital stay duration for bronciolitis children with vitamin D was significantly shorter than children with no vitamin D (p<0.001). This finding coincides with results of many literatures such as Saad et al (24) study in Egypt, Allen et al (25) study in UK and Belderbos et al (26) study in Netherlands which all found that supplementing infants and children who had bronchiolitis with vitamin D had an obvious role in decreasing the hospitalization duration which represented a highly cost benefit characteristic.…”

Section: Discussion:-supporting

confidence: 91%

Role of Vitamin D on Treatment of Bronchiolitis in Children

Falah¹,

FICMS²,

CABP³

2020

IJAR

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Background: Vitamin D plays a major role in growth and development of children. Optimal levels of vitamin D in first year of life are found to be preventive for lower respiratory tract infections. Aim of Study:To assess the effect of vitamin D supplementation on treatment of bronchiolitis. Patients and methods:This study is prospective follow up study conducted in Pediatric Wards of Al-Imamain Medical city in Baghdad through the period from 1 st of January, 2018 to 31 st of January, 2019 on convenient sample of 200 children with bronchiolitis divided into two group .group A include 98 children who were managed by traditional treatment of bronchiolitis (oxygen ,fluid ,frequent sucking of secretion ) and V.D supplementation (400 iu)daily and group B that include 102 children managed with traditional treatment only . The vital signs and hospital stay duration of children were assessed daily . Results: No significant differences were observed between two study groups regarding demographic, social, clinical and feeding characteristics. Also no significant differences were observed regarding respiratory rate at admission and at discharge. There was a significant difference regarding heart rate at discharge (p=0.05). A significant association was observed between children with vitamin D and shorter hospital stay duration (p<0.001).

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Section: Discussion:-supporting

confidence: 91%

Role of Vitamin D on Treatment of Bronchiolitis in Children

Falah¹,

FICMS²,

CABP³

2020

IJAR

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“…A supplementation of 50,000 IU/day for 2 days was tried in Iran in children with pneumonia and it did not influence the severity of symptoms, however the study reported a lower duration of antibiotic use in the intervention group [ 166 ]. Contrasting evidence was found in a 2015 Egyptian trial on children hospitalized for bronchiolitis [ 161 ], where the administration of vitamin D 100 IU/kg/day for 5 days was associated with a significant improvement in the duration of hospitalization and time taken to improve oral feeding. The efficacy of a high dose, short-term supplementation of vitamin D in preventing respiratory tract infections was also analyzed in 2012 by Manaseki-Holland and colleagues [ 157 ], who found 100,000 IU supplementation every 3 months ineffective in reducing the incidence of pneumonia, and later in 2019 by Singh et al [ 169 ], who achieved similar results with a 300,000 IU supplementation every 3 month.…”

Section: Vitamin Dmentioning

confidence: 84%

“…These observational findings have laid the foundation for clinical trials of vitamin D supplementation for treatment or prevention of childhood respiratory tract infections, as shown in Table 6 a,b [ 155 , 156 , 157 , 158 , 159 , 160 , 161 , 162 , 163 , 164 , 165 , 166 , 167 , 168 , 169 , 170 ].…”

Section: Vitamin Dmentioning

confidence: 99%

The Role of Micronutrients in Support of the Immune Response against Viral Infections

et al. 2020

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Viral infections are a leading cause of morbidity and mortality worldwide, and the importance of public health practices including handwashing and vaccinations in reducing their spread is well established. Furthermore, it is well known that proper nutrition can help support optimal immune function, reducing the impact of infections. Several vitamins and trace elements play an important role in supporting the cells of the immune system, thus increasing the resistance to infections. Other nutrients, such as omega-3 fatty acids, help sustain optimal function of the immune system. The main aim of this manuscript is to discuss of the potential role of micronutrients supplementation in supporting immunity, particularly against respiratory virus infections. Literature analysis showed that in vitro and observational studies, and clinical trials, highlight the important role of vitamins A, C, and D, omega-3 fatty acids, and zinc in modulating the immune response. Supplementation with vitamins, omega 3 fatty acids and zinc appears to be a safe and low-cost way to support optimal function of the immune system, with the potential to reduce the risk and consequences of infection, including viral respiratory infections. Supplementation should be in addition to a healthy diet and fall within recommended upper safety limits set by scientific expert bodies. Therefore, implementing an optimal nutrition, with micronutrients and omega-3 fatty acids supplementation, might be a cost-effective, underestimated strategy to help reduce the burden of infectious diseases worldwide, including coronavirus disease 2019 (COVID-19).

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“…The findings of the only randomized, double-blind, placebo-controlled trial of vitamin D therapy for bronchiolitis in infants (3 to 23 months age), which was conducted in Egypt, are in support of the above theory. The authors reported that the group receiving 100 IU/kg/day for 7 days had significant improvements in the time taken for resolution of the disease and to return to oral feeding, as well as in the duration of hospitalization, compared to those on placebo [82].…”

Section: Vitamin D Supplementation and Lrimentioning

confidence: 99%

The association between vitamin D status and infectious diseases of the respiratory system in infancy and childhood

2019

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Purpose Respiratory tract infections (RTIs) are a major cause of illness worldwide and the most common cause of hospitalization for pneumonia and bronchiolitis. These two diseases are the leading causes of morbidity and mortality among children under 5 years of age. Vitamin D is believed to have immunomodulatory effects on the innate and adaptive immune systems by modulating the expression of antimicrobial peptides, like cathelicidin, in response to both viral and bacterial stimuli. The aim of this review is to summarize the more recently published data with regard to potential associations of 25-hydroxyvitamin D [25(OH)D] with infectious respiratory tract diseases of childhood and the possible health benefits from vitamin D supplementation. Methods The literature search was conducted by using the PubMed, Scopus, and Google Scholar databases, with the following keywords: vitamin D, respiratory tract infection, tuberculosis, influenza, infancy, and childhood. Results Several studies have identified links between inadequate 25(OH)D concentrations and the development of upper or lower respiratory tract infections in infants and young children. Some of them also suggest that intervention with vitamin D supplements could decrease both child morbidity and mortality from such causes. Conclusions Most studies agree in that decreased vitamin D concentrations are prevalent among most infants and children with RTIs. Also, normal to high-serum 25(OH)D appears to have some beneficial influence on the incidence and severity of some, but not all, types of these infections. However, studies with vitamin D supplementation revealed conflicting results as to whether supplementation may be of benefit, and at what doses.

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Trial of Vitamin D Supplementation in Infants with Bronchiolitis: A Randomized, Double-Blind, Placebo-Controlled Study

Cited by 15 publications

References 22 publications

Role of Vitamin D on Treatment of Bronchiolitis in Children

Role of Vitamin D on Treatment of Bronchiolitis in Children

The Role of Micronutrients in Support of the Immune Response against Viral Infections

The association between vitamin D status and infectious diseases of the respiratory system in infancy and childhood

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