Trial Protocol: Cognitive functional therapy compared with combined manual therapy and motor control exercise for people with non-specific chronic low back pain: protocol for a randomised, controlled trial

Belache, Fabiana Terra Cunha; Souza, Cíntia Pereira de; Fernandez, Jessica; Castro, Julia; Ferreira, Paula dos Santos; Rosa, Elizana Rodrigues de Sousa; Araújo, Nathalia Cristina Gimenez de; Reis, Felipe José Jandre dos; Almeida, Renato Santos de; Nogueira, Leandro Alberto Calazans; Correia, Luís Cláudio Lemos; Meziat‐Filho, Ney

doi:10.1016/j.jphys.2018.02.018

Cited by 11 publications

(7 citation statements)

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“…Clinical studies have reported that patients with LBP often exhibit obsessive‐compulsive disorder, panic disorder, and anxiety 22,23 . Anxiety disorders aggravate the occurrence and development of LBP, and the relationship between LBP and anxiety has recently attracted growing attention 24,25 .…”

Section: Introductionmentioning

confidence: 99%

Resveratrol‐enhanced SIRT1‐mediated osteogenesis in porous endplates attenuates low back pain and anxiety behaviors

Chen

Gao

et al. 2021

FASEB j.

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Low back pain (LBP) is a major clinical problem that lacks effective treatments. The sensory innervation in porous vertebral endplates and anxiety contributes to spinal hyperalgesia. We hypothesized that SIRT1 activator resveratrol alleviates LBP and anxiety via promotion of osteogenesis in the porous endplates. The hyperalgesia and anxiety‐related behaviors; sensory innervation, inflammation and porosity of endplates; and osteogenic/osteoclastic factors expression were measured following resveratrol treatment after lumbar spine instability (LSI) surgery. To explore whether resveratrol promotes endplates osteogenesis and thus alleviates LBP through activation of SIRT1 in the osteoprogenitor cells of endplates, SIRT1OSX−/− mice were employed. Additionally, the levels of inflammation markers, phosphorylation of cAMP response element‐binding protein (pCREB), and brain‐derived neurotrophic factor (BDNF) in hippocampus were evaluated. After 4 or 8 weeks LSI surgery, the mice suffered from hyperalgesia and anxiety, which were efficiently attenuated by resveratrol at 8 weeks. Resveratrol treatment‐enhanced osteogenesis and decreased endplates porosities accompanied with the reduction of TNFα, IL‐1β, and COX2 levels and CGRP+ nerve fibers innervation in porous endplates. Resveratrol‐mediated endplates osteogenesis, decreased endplates porosities, and analgesic and antianxiety effects were abrogated in SIRT1OSX−/− mice. Furthermore, resveratrol relieved inflammation and increased pCREB and BDNF expression in the hippocampus after 8 weeks, which alleviate anxiety‐related behaviors. This study provides that resveratrol‐mediated porous endplates osteogenesis via the activation of SIRT1 markedly blocked sensory innervation and inflammation in endplates, therefore, alleviating LSI surgery‐induced LBP and hippocampus‐related anxiety.

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Section: Introductionmentioning

confidence: 99%

Resveratrol‐enhanced SIRT1‐mediated osteogenesis in porous endplates attenuates low back pain and anxiety behaviors

Chen

Gao

et al. 2021

FASEB j.

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“…The presence of psychological factors as anxiety and insecurity in people with low back symptoms is associated with the risk of developing disability (Hartvigsen et al, 2018;Lardon et al, 2018). Anxiety, is also, associated with pain, growth of symptomatology and pain behaviors (Andersen et al, 2018;Belache et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Impact of workplace exercise program in the musculoskeletal symptomatology of warehouse workers: randomized control trial

Mesquita,

Félix,

Lopes

et al. 2024

R. G. Secr.

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In industrialization sector, musculoskeletal disorders are very frequent and can be considered as one of the main problems. They are associated with pain, discomfort, and functional limitations. Exercise programs can improve the symptomatology and daily life activities. Aims: Evaluate the impact of a 21-month exercise program on musculoskeletal symptoms reports of warehouse workers. Methods and Materials: This study was a randomized controlled trial based on CONSORT guidelines. Sample was 249 male workers, randomized in two groups (96 intervention and 124 control group). The Portuguese version of Nordic Musculoskeletal Questionnaire was used to evaluate the musculoskeletal symptomatology at baseline (M0), after 11 months (M1) and after 21 months (M2). The flexibility, mobility and strengthening exercises were executed at the beginning of the working time, once a day, lasting eight minutes. The data were analyzed in SPSS® 25.0 for Windows® (p<0.05). Results: We verify a higher prevalence of problems in different body regions at both groups. The most common symptom, with higher proportion across all variables, was the low back region, followed by the neck, in both groups Most symptomatology was low back region in both groups before intervention. In the intervention group, was verify decrease of symptoms, “problems in the last 12 months”, at M0/M1 (p=0.005) and M0/M2 (p=0.021); “limitations in the last 12 months”, at M0/M1 (p=0.004) and M0/M2 (p<0.001); and “problems in the last 7 days”, at M0/M1 (p=0.017) and M0/M2 (p=0.02). In the control group was verified an increased symptoms at M0/M2 (p=0.038) in “problems in the last 12 months”. Conclusions: It can be concluded that the implementation of a 21-month workplace exercise program contributes to decrease the report of low back symptoms of warehouse workers.

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“… 36 Lately, there has been a shift towards incorporating pain education and CB treatment approaches by PT’s for the treatment of back pain. 37 , 38 In this systematic review, the inclusion criteria involve every field of the cognitive-behavioral and biopsychosocial parameters.…”

Section: Discussionmentioning

confidence: 99%

The cognitive-behavioral aspects of the Mulligan concept of manual therapy: A systematic review

Athanasiadis¹,

Dionyssiotis

Krumov

et al. 2022

Eur J Transl Myol

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Low back pain (LBP) is a common clinical problem imposing a prominent socio-economic burden. The purpose of this systematic review was to investigate the biopsychosocial effects of the Mulligan Concept (MC) of manual therapy (MT) when applied to patient's with LBP. Three researchers independently evaluated the literature quality, and completed a review on five online databases (Medline, Cochrane Library, Science Direct, ProQuest and Google Scholar) for articles published from January 1st 2010 to November 20th 2021, using a combination of free words, Wildcards and Medical Subject Headings (MESH) terms: " Mulligan mobilization " AND " back pain " OR " SNAGs." In total, 62 studies were selected for full-text reading, from which finally 6 studies were included in the present review. The results revealed that the studies where the MC of MT was applied to treat LBP mainly lacked concern regarding the effect that the intervention has on the cognitive and behavioural parameters. The ones that introduced measure outcomes for at least some parts of the cognitive behavioural components, showed that the MC has a positive effect, even though without a long-term follow-up assessment. This review summarized that the evidence of the MC on cognitive behavioural (CB) aspects of patients with LBP is controversial and scarce.

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Trial Protocol: Cognitive functional therapy compared with combined manual therapy and motor control exercise for people with non-specific chronic low back pain: protocol for a randomised, controlled trial

Cited by 11 publications

References 0 publications

Resveratrol‐enhanced SIRT1‐mediated osteogenesis in porous endplates attenuates low back pain and anxiety behaviors

Resveratrol‐enhanced SIRT1‐mediated osteogenesis in porous endplates attenuates low back pain and anxiety behaviors

Impact of workplace exercise program in the musculoskeletal symptomatology of warehouse workers: randomized control trial

The cognitive-behavioral aspects of the Mulligan concept of manual therapy: A systematic review

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