Trial to control an outbreak of Panton-Valentine leukocidin–positive methicillin-resistant Staphylococcus aureus at a boarding school in Japan

Higashiyama, Masaaki; Ito, Teruyo; Han, Xia; Nishiyama, Junichiro; Tanno, Akemi; Wada, Toshiko; Funaoka, Youichi; Yoshida, Yusuke; Mikita, Kei; Ogawa, Tomomichi; Okusa, Yasushi; Kaku, Koki; Hatada, Junichi; Hiramatsu, Kazumasa; Kawana, Akihiko

doi:10.1016/j.ajic.2011.02.010

Cited by 10 publications

(7 citation statements)

References 14 publications

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“…PVL is a leukocidal toxin that has been suggested to increase the virulence potential of CA-MRSA strains and is often associated with severe skin and soft tissue infections (Boyle-Vavra and Daum 2007 , Wu et al 2010 , Guillén et al 2016 , Hewagama et al 2016 , Immergluck et al 2017 ). Outbreaks of MRSA-PVL-positive strains have been reported in both healthcare and community settings, in some cases involving healthy individuals with no MRSA-associated risk factors (Tang et al 2007 , Maltezou et al 2009 , Higashiyama et al 2011 ). These studies highlight how MRSA-PVL-positive strains could be easily spread (to other individuals and/or the environment) within a particular facility, especially when appropriate precautions (including—but not exclusive to—infection control, preventive measures, and personal hygiene) are not followed.…”

Section: Discussionmentioning

confidence: 99%

High Prevalence of Multidrug-Resistant Community-Acquired Methicillin-Resistant Staphylococcus aureus at the Largest Veterinary Teaching Hospital in Costa Rica

Rojas

Barquero-Calvo

Balen

et al. 2017

Vector-Borne and Zoonotic Diseases

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Methicillin-resistant Staphylococcus aureus (MRSA) is a pathogen associated with severe infections in companion animals present in the community, and it is diagnosed in animals admitted to veterinary hospitals. However, reports that describe the circulation of MRSA in animal populations and veterinary settings in Latin America are scarce. Therefore, the objective of this study was to determine the prevalence and investigate the molecular epidemiology of MRSA in the environment of the largest veterinary teaching hospital in Costa Rica. Preselected contact surfaces were sampled twice within a 6-week period. Antimicrobial resistance, SCCmec type, Panton-Valentine leukocidin screening, USA type, and clonality were assessed in all recovered isolates. Overall, MRSA was isolated from 26.5% (27/102) of the surfaces sampled, with doors, desks, and examination tables most frequently contaminated. Molecular analysis demonstrated a variety of surfaces from different sections of the hospital contaminated by three highly related clones/pulsotypes. All, but one of the isolates were characterized as multidrug-resistant SCCmec type IV-USA700, a strain sporadically described in other countries and often classified as community acquired. The detection and frequency of this unique strain in this veterinary setting suggest Costa Rica has a distinctive MRSA ecology when compared with other countries/regions. The high level of environmental contamination highlights the necessity to establish and enforce standard cleaning and disinfection protocols to minimize further spread of this pathogen and reduce the risk of nosocomial and/or occupational transmission of MRSA.

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Section: Discussionmentioning

confidence: 99%

High Prevalence of Multidrug-Resistant Community-Acquired Methicillin-Resistant Staphylococcus aureus at the Largest Veterinary Teaching Hospital in Costa Rica

Rojas

Barquero-Calvo

Balen

et al. 2017

Vector-Borne and Zoonotic Diseases

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“…(5) More recent studies collectively indicate that enhanced hygiene in schools and targeted cleaning of biological residual contamination related to frequent contact points result in reduced illnesses tied into bacterial contamination reservoirs (MRSA, Shigella outbreaks), reduced sick building syndrome symptoms, and reduced absenteeism due to infectious illness. (6)(7)(8)(9)(10) Adenosine triphosphate (ATP) has historically been used successfully as an important marker for the detection and quantification of pollutant loads of biological origin and overall cleanliness in the food production and food service industries, and it has been recently confirmed as a representative marker for detection of levels of surface contamination in hospital settings. (11,12) Previous research has also identified the use of ATP marker as a feasible, rapid, real-time, quantitative, and economical approach to the measurement of cleaning effectiveness on a variety of surfaces and materials in school buildings.…”

Section: Introductionmentioning

confidence: 99%

ATP as a Marker for Surface Contamination of Biological Origin in Schools and as a Potential Approach to the Measurement of Cleaning Effectiveness

Shaughnessy

Cole

Moschandreas

et al. 2013

Journal of Occupational and Environmental Hygiene

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To address the need for a quantitative approach to the measurement of cleaning effectiveness, related to biologically derived surface contamination, three commercially available adenosine triphosphate (ATP) test systems were used to collect multiple samples measured in relative light units (RLUs) from 27 elementary schools in the southwestern United States before and after a standardized cleaning protocol. The database consisted of 6480 ATP measurements from four critical surfaces (student desktops, cafeteria tabletops, and restroom sinks and stall doors). Data was assessed according to ranges of ATP values before and after cleaning. Results showed the potential for such data to provide the basis for a standardized approach to the measurement of cleaning effectiveness, based on detection and quantification of pollutant loads of biological origin, across critical surfaces in school building environments. It is anticipated that verification of this data in school buildings across different geographic and climatic regions will lead to the establishment of "acceptable" ranges of ATP values that can be used as a practice-based approach to improving cleaning practices and contributing to healthier school environments.

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“…William et al (2004) found that levels of nasal carriage of S. aureus increased after training at an indoor venue, whereas levels of skin carriage decreased, possibly due to lysozyme activity in sweat. Higashiyama et al (2011) found increased rates of colonization during an outbreak of skin infections, which decreased significantly following implementation of infection control practices.…”

Section: Methodsmentioning

confidence: 96%

“…Contamination of sports facilities with S. aureus was studied by Oller, Province, and Curless (2010); Montgomery, Ryan, Krause, and Starkey (2010), and Higashiyama et al (2011) all of whom detected pathogens in facilities. The fingertips of footballers harbored high numbers of S. aureus .…”

Section: Methodsmentioning

confidence: 99%

Skin Infections in Young People (Aged 14–18 Years)

Lambe¹,

Hoare

2013

The Journal of School Nursing

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Skin infections are a major cause of preventable hospitalization, with young people being particularly susceptible. Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infection typically presents as skin infection. CA-MRSA infection rates have increased rapidly in the past decade. Exploration of literature specific to young people aged 14-18 years is therefore timely. Integrative review using the methods described by Whittemore and Knafl was undertaken. Electronic databases of Medline, CINAHL, Scopus, Cochrane Database of Systematic Reviews, and Google databases were searched for English-language articles published after 1990. Twenty primary studies were included and the findings are reported here. Data analysis revealed factors influencing skin infections in young people may be host-, transmission-, or pathogen-specific. Strategies to address host and transmission factors may be effective in controlling skin infection rates in young people.

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Trial to control an outbreak of Panton-Valentine leukocidin–positive methicillin-resistant Staphylococcus aureus at a boarding school in Japan

Cited by 10 publications

References 14 publications

High Prevalence of Multidrug-Resistant Community-Acquired Methicillin-Resistant Staphylococcus aureus at the Largest Veterinary Teaching Hospital in Costa Rica

High Prevalence of Multidrug-Resistant Community-Acquired Methicillin-Resistant Staphylococcus aureus at the Largest Veterinary Teaching Hospital in Costa Rica

ATP as a Marker for Surface Contamination of Biological Origin in Schools and as a Potential Approach to the Measurement of Cleaning Effectiveness

Skin Infections in Young People (Aged 14–18 Years)

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