Trials of alum-precipitated pollen extracts in the treatment of hay fever

Norman, Philip S.; Winkenwerder, Walter L.; Lichtenstein, Lawrence M.

doi:10.1016/0091-6749(72)90077-2

Cited by 80 publications

(20 citation statements)

References 14 publications

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“…The prospect of less injec tions and yet satisfactory dose levels, is a most practical goal. Alum ex tracts have been shown to be efficacious [10]. In this study the alum frac tion A and aqueous fraction A were equally effective.…”

Section: Discussionmentioning

confidence: 70%

Clinical and Immunoiogical Studies Following Immunotherapy with Aqueous and Alum Precipitated Ragweed Fraction A

Reisman¹,

Arbesman²

1973

Int Arch Allergy Immunol

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Fraction A contains all of the major antigens and allergenic properties of whole ragweed extract, but lacks the yellow pigment and some low molecular weight substances. In a double blind study, the clinical and immunoiogical responses were observed following administration of aqueous and alum precipitated extracts of fraction A to 21 previously nonimmunized ragweed sensitive patients. Both preparations of fraction A were clinically effective. The reactions which occurred after the alum and aqueous extract injections were similar in incidence and character. The immunoiogical response following both extracts was also quite similar. In the majority of patients, serum total IgE levels rose, both as the result of immunotherapy and seasonal exposure. Ragweed radioallergosorbent (RAST) antibody levels, a measure of reagin, dropped in two thirds of the patients following therapy and remained unchanged in all patients during inhalant pollen exposure. Hemagglutinating antibody titers generally rose. Aqueous and alum precipitated fraction A extracts were clinically and immunologically effective. However, further studies are needed to establish any advantage of fraction A over present whole ragweed extract preparations.

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Section: Discussionmentioning

confidence: 70%

Clinical and Immunoiogical Studies Following Immunotherapy with Aqueous and Alum Precipitated Ragweed Fraction A

Reisman¹,

Arbesman²

1973

Int Arch Allergy Immunol

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“…Their "dose" was gradually increased so that they developed wheal and flare reactions to the histamine which mimicked the reactions reported by the other group. Specific therapy was with alum-precipitated crude ragweed extract prepared by Center Laboratories (20). Injections were started with 1 Ag protein N (100 PNU) and doubled weekly unless this was prevented by severe local or generalized reactions.…”

Section: Introductionmentioning

confidence: 99%

IgE Antibody Measurements in Ragweed Hay Fever RELATIONSHIP TO CLINICAL SEVERITY AND THE RESULTS OF IMMUNOTHERAPY

Lichtenstein¹,

Ishizaka²,

Norman³

et al. 1973

J. Clin. Invest.

326

129

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A B S T R A C T Specific IgE anti-ragweed antibodies (IgEAR) were measured over two years in two groups of highly sensitive patients treated (immunized) with either ragweed extract or placebo and in a third group of placebo-treated, relatively insensitive patients. TheIgEAR on the patients' basophils were assessed by ragweed antigen E (AgE)-induced histamine release; blocking (IgG) antibodies were measured by their ability to inhibit AgE induced histamine release. These data were evaluated against the clinical severity of ragweed hay fever in each patient.

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“…It has become a general assumption that IT does not induce formation of IgE towards components in allergen extracts to which the patient has not hitherto reacted. There are, however, examples of induction of IgE following injection of allergen extracts in non-allergic subjects (32,62,79,117). In an IT study 0sterballe demonstrated by means of the GRIE-technique that no new IgE-specificities were induced by a timothy grass pollen extract (131).…”

Section: Igementioning

confidence: 99%

“…Since 1970 a vast amount of publications have emerged on possible improvements of IT by means of allergen modifications. From an immunochemical viewpoint it seems appropriate to divide modified allergen extracts into three groups: (66,79). Compared with aqueous allergen extract no higher levels of specific IgE were observed (66), w^hereas the levels of specific IgG were slightly increased (66) or unchanged (79).…”

Section: Modification Of Allergensmentioning

confidence: 99%

“…From an immunochemical viewpoint it seems appropriate to divide modified allergen extracts into three groups: (66,79). Compared with aqueous allergen extract no higher levels of specific IgE were observed (66), w^hereas the levels of specific IgG were slightly increased (66) or unchanged (79). As opposed to this, immunization of healthy subjects with alum-adsorbed native allergens or "allergoids" leads to formation of specific IgE, allergen specific histamine release from leucocytes and skin reactivity to the allergens, although no clinical evidence of allergy was observed (58).…”

Section: Modification Of Allergensmentioning

confidence: 99%

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