Triamcinolone permeation from different liposome formulations through rat skin in vitro

Yu, Hsiu‐Ying; Liao, Huimin

doi:10.1016/0378-5173(95)04055-2

Cited by 68 publications

(27 citation statements)

References 10 publications

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“…[43] observed that incorporation of progesterone in liquid-state liposomes resulted in a higher skin permeation rate than when incorporated in gel-state liposomes. Yu and Liao [59] reported that TRMA in the PC liposome (J value, 1.0 8 0.1) showed a signifi cantly higher permeated amount of TRMA than that in the dipalmitoyl PC liposomes (J value, 0.64 8 0.05) and ointment (J value, 0.25 8 0.02). Also, they reported that liposomes consisting of skin lipid composition (J value, 4.7 8 0.2) more signifi cantly enhanced the skin permeation of TRMA than other liposomes.…”

Section: Compositionmentioning

confidence: 99%

“…Yu and Liao [59] reported the effect of MLV size on the TRMA permeation. There was no difference in MLV with different size, from 1 to 0.2 m. The size of MLV may not infl uence TT drug delivery.…”

Section: Liposomal Sizementioning

confidence: 99%

“…Lipid compositions infl uenced the TT delivery activities of various drugs, such as progestrone and TRMA [43,59] . Knepp et al.…”

Section: Compositionmentioning

confidence: 99%

“…Because drug carriers must pass through fi ne pores, liposome's size may infl uence TT delivery of drugs through microroutes, such as the intercellular and the transcellular route. It was assumed that a decrease in particle size of the liposomes would result in an increase of the amount of drug found in the deeper skin [59] . However, if liposomes mainly permeate through follicles, liposome size may not infl uence TT drug delivery.…”

Section: Liposomal Sizementioning

confidence: 99%

“…To compare the effects of different vesicles, Yu and Liao [59] prepared small unilamellar vesicles (SUV) and multilamellar vesicles (MLV) with negative surface charge. The negative SUV (J value, 1.4 8 0.2) with a diameter of 35 nm gave a signifi cantly higher permeation than the corresponding MLVs (J value, 0.68 8 0.09) of the same charge.…”

Section: Liposomal Sizementioning

confidence: 99%

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Liposomes and Niosomes as Topical Drug Delivery Systems

Choi

Maibach

2005

Skin Pharmacol Physiol

214

104

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The skin acts as a major target as well as a principle barrier for topical/transdermal (TT) drug delivery. The stratum corneum plays a crucial role in barrier function for TT drug delivery. Despite major research and development efforts in TT systems and the advantages of these routes, low stratum corneum permeability limits the usefulness of topical drug delivery. To overcome this, methods have been assessed to increase permeation. One controversial method is the use of vesicular systems, such as liposomes and niosomes, whose effectiveness depends on their physicochemical properties. This review focuses on the effect of liposomes and niosomes on enhancing drug penetration, and defines the effect of composition, size and type of the vesicular system on TT delivery.

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Section: Compositionmentioning

confidence: 99%

Section: Liposomal Sizementioning

confidence: 99%

“…Lipid compositions infl uenced the TT delivery activities of various drugs, such as progestrone and TRMA [43,59] . Knepp et al.…”

Section: Compositionmentioning

confidence: 99%

Section: Liposomal Sizementioning

confidence: 99%

Section: Liposomal Sizementioning

confidence: 99%

See 3 more Smart Citations

Liposomes and Niosomes as Topical Drug Delivery Systems

Choi

Maibach

2005

Skin Pharmacol Physiol

214

104

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Liposomes and Drug Delivery

Antimisiaris

Kallinteri

Fatouros³

2010

Pharmaceutical Sciences Encyclopedia

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Liposomes are vesicles in which an aqueous volume is entirely surrounded by a phospholipid membrane and their size can range between 30 and 50 nm up to several micrometers. Liposomes serve as a drug delivery system because of their versatile structure and because they are nontoxic, nonimmunogenic, and fully biodegradable. This chapter focuses on basic characteristics and applications of liposomes, their fate after in vivo administration by different routes, and other possible routes for in vivo administration of liposomes.

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Hydroxyapatite/polyurethane scaffold incorporated with drug‐loaded ethyl cellulose microspheres for bone regeneration

et al. 2010

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The purpose of this study is to explore and develop biodegradable scaffold for bone regeneration or tissue engineering with the capacity of controlled drug delivery. Ceftazidime as a model drug was encapsulated in ethyl cellulose (EC) microspheres, which were subsequently incorporated in a hydroxyapatite/polyurethane (HA/PU) composite scaffold to generate an antibiotic drug delivery system. HA/PU scaffolds had an interconnected pore network with an average porosity of about 83%. The presence of microspheres in the composite scaffolds was confirmed by scanning electron microscopy. The drug-loaded EC microspheres were uniformly distributed in the HA/PU scaffold matrix and showed no significant effect on the pore structure of the scaffold. Incorporation of microspheres into scaffolds significantly reduced the initial burst release, and the system exhibited a sustained release of the model drug for up to 60 days. Moreover, the scaffold with drug-loaded microspheres was proved to be an effective drug delivery system with good cytocompatibility and antibacterial properties. The novel drug-loaded microsphere/scaffold composites developed in this study are promising to serve as vehicles for controlled drug delivery in bone regeneration or bone tissue engineering.

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Triamcinolone permeation from different liposome formulations through rat skin in vitro

Cited by 68 publications

References 10 publications

Liposomes and Niosomes as Topical Drug Delivery Systems

Liposomes and Niosomes as Topical Drug Delivery Systems

Liposomes and Drug Delivery

Hydroxyapatite/polyurethane scaffold incorporated with drug‐loaded ethyl cellulose microspheres for bone regeneration

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