Triamcinolone reduces seroma re-accumulation in the extended latissimus dorsi donor site

A Comparison of Triamcinolone Acetonide and Fibrin Glue for Seroma Prevention in a Rat Mastectomy Model

“…Chung et al 20 prevented capsular contracture by the instillation of triamcinolone on the capsules around breast implants in animal models. Taghizadeh et al 13 reported that triamcinolone injection was effective in inhibiting seroma reaccumulation after seroma formation in the latissimus dorsi donor site, whereas Rogliani et al 14 treated seroma formation by cortisone. Triamcinolone has been used to clinically treat seroma formation, but has never been used intraoperatively to prevent seroma formation.…”

“…Moreover, Bacilious et al 18 revealed that seroma formation was basically associated with an inflammatory reaction, and more intense inflammatory cell infiltrations and less collagen deposition was correlated with seroma formation and wound healing impairment in their histopathological study. On the basis of triamcinolone acetonide being used principally as an anti-inflammatory agent and for treating seroma, 13,14 the authors in this study applied it to prevent seroma formation in an animal model, and its effectiveness was compared with fibrin glue. As a result, triamcinolone acetonide demonstrated significant effect on the reduction of inflammation and seroma prevention, although the fibrin glue, which has been shown to reduce inflammation, 19 was also effective.…”

“…13,14 Therefore, in this study authors used it to prevent seroma formation in a rat mastectomy model and compared its effectiveness with fibrin glue.…”

Seroma Production After Breast Cancer Surgery has a Pro-Inflammatory Component

“…The lack of immune suppression of the steroid could be because no sustained release formula was used or because the dose was too small. In contrast, Taghizadeh et al demonstrated a significant reduction of seroma formation when steroid was administered into the cavity at the site of seroma puncture [22]. Rogliani et al demonstrated reduced seroma production after steroid injections in the extended latissimus dorsi donor site after reconstructive surgery [23].…”

A Prospective Randomized Trial of the Efficacy of Marginal Quilting Sutures and Fibrin Sealant in Reducing the Incidence of Seromas in the Extended Latissimus Dorsi Donor Site

“…These include the avoidance of diathermy, quilting of skin flaps, endoscopic harvest, prolonged drainage, pressure dressings, aspiration, sclerotherapy, steroid injection, and capsulectomy. 2,[5][6][7][8][9][10][11][12][13][14][15] Unfortunately, these preventative measures are not uniformly successful, and occasionally chronic seromas can occur, which are very resistant to treatment due to the formation of a fibrous capsule. 16 The most commonly used modality is quilting of the donor site.…”