Triamterene and Hydrochlorothiazide in the Treatment of Hypertension.

Heath, William C.

doi:10.7326/0003-4819-60-2-317_2

Cited by 6 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…TA has been utilized either alone [18,19] or in combi nation with potassium-wasting diuretics, such as thia zides [4,[20][21][22] or furosemide [23,24], to both increase natriuresis as well as to minimize the ensuing kaliuresis. TA inhibits passive sodium transport from the luminal side of transporting epithelia [25][26][27], resulting in im paired movement of potassium from cell to lumen, since the latter is functionally coupled to sodium movement.…”

Section: Pharmacodynamicsmentioning

confidence: 99%

“…TA has only mild antihypertensive properties either when administered alone [18][19][20]30] or when it is utilized in a complementary fashion with thiazide-type diuretics [20], Consequently, the major pharmacodynamic consid eration for TA relates not to its antihypertensive proper ties but, rather, to its dose proportionality relative to potassium supplements [21,31] or other potassium-spar ing diuretics [31] in normalizing extra-and intracellular potassium deficiencies consequent to diuretic use.…”

Section: Pharmacodynamicsmentioning

confidence: 99%

See 1 more Smart Citation

Triamterene and the Kidney

Sica¹,

Gehr²

1989

Nephron

View full text Add to dashboard Cite

Triamterene (TA) is a mild ‘potassium-sparing’ diuretic usually employed in combination with other more potent diuretics in the treatment of hypertension. TA pharmacokinetics and pharmacodynamics in normal volunteers, elderly subjects and in patients with renal and hepatic dysfunction are reviewed. A variety of adverse renal effects, such as abnormalities in urinary sediment, nephrolithiasis, interstitial nephritis and acute renal failure, has been reported to occur and is also reviewed. Of particular concern with the increased availability of ‘over-the-counter’ nonsteroidal anti-inflammatory medications (NSAID) is the adverse interaction between TA and NSAID which may culminate in acute renal failure. Although a rare occurrence, the clinician should be aware of potential adverse reactions associated with the use of TA.

show abstract

Section: Pharmacodynamicsmentioning

confidence: 99%

Section: Pharmacodynamicsmentioning

confidence: 99%

Triamterene and the Kidney

Sica¹,

Gehr²

1989

Nephron

View full text Add to dashboard Cite

show abstract

“…The selection of this ratio was based on the Received for publication June 20, 1966. suggestion of Heath and Freis. 7 Despite the widespread use of this combination in investigations,lO, 11,12 metabolic balance studies comparing the activity of hydrochlorothiazide and such a mixture have not been published. The purpose of this report is to present the results of such studies.…”

mentioning

confidence: 99%

A comparison of the effects of hydrochlorothiazide and hydrochlorothiazide in combination with triamterene on electrolyte balance

Tannenbaum

Crosley

1966

Clin Pharma and Therapeutics

View full text Add to dashboard Cite

A comparison of hydrochlorothiazide alone and a combination of triamterene and hydrochlorothiazide in a ratio of 2:1 was made in 9 nonedematous patients, with the use of a metabolic balance technique. The results indicated that the mixture produces a greater natriuretic effect than can be produced by hydrochlorothiazide alone. However, whereas doubling the doses of the combination of 100 mg. of triamterene and 50 mg. of hydrochlorothiazide per day had no greater natriuretic effect, the doubled quantities did result in a greater reduction of potassium loss. These findings are of value in defining the manner in which such agents exert their activity on distal tubular transport systems. The use of triameterene and hydrochlorothiazide in combination tends to eliminate the undesirable effects of each of these agents on potassium and acid-base balance. Finally, the use of the combination as the first test agent exaggerated the difference between the ensuing natriuretic response and that produced by hydrochlorothiazide. These results indicated the importance of the order of drug administration in comparing diuretic efficacy in a crossover investigation.

show abstract

Management of Potassium Problems During Long-Term Diuretic Therapy

Kosman¹

1974

JAMA

View full text Add to dashboard Cite

Triamterene and Hydrochlorothiazide in the Treatment of Hypertension.

Cited by 6 publications

References 0 publications

Triamterene and the Kidney

Triamterene and the Kidney

A comparison of the effects of hydrochlorothiazide and hydrochlorothiazide in combination with triamterene on electrolyte balance

Management of Potassium Problems During Long-Term Diuretic Therapy

Contact Info

Product

Resources

About