We formulate and give partial answers to several combinatorial problems on volumes of simplices determined by n points in 3-space, and in general in d dimensions. (i) The number of tetrahedra of minimum (nonzero) volume spanned by n points in R 3 is at most 2 3 n 3 − O(n 2 ), and there are point sets for which this number is 3 16 n 3 − O(n 2 ). We also present an O(n 3 ) time algorithm for reporting all tetrahedra of minimum nonzero volume, and thereby extend an algorithm of Edelsbrunner, O'Rourke, and Seidel. In general, for every k, d ∈ N, 1 ≤ k ≤ d, the maximum number of k-dimensional simplices of minimum (nonzero) volume spanned by n points in R d is Θ(n k ). (ii) The number of unit-volume tetrahedra determined by n points in R 3 is O(n 7/2 ), and there are point sets for which this number is Ω(n 3 log log n). (iii) For every d ∈ N, the minimum number of distinct volumes of all full-dimensional simplices determined by n points in R d , not all on a hyperplane, is Θ(n).