Triazinone herbicide metribuzin induced acute liver injury: A study of animal model

Derouiche, Samir; Selma, Rezzag mohcen Om; Asma, Serouti

doi:10.4103/2221-6189.241016

Cited by 9 publications

(2 citation statements)

References 1 publication

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“…Lipid peroxidation owing to free radical activity plays an important role in complications of diabetes (37). In fact, oxidative stress plays an important role in the development and progression of DM due to higher free radical production, damage to cell constituents, and impairment in the antioxidant defense enzymes, such as superoxide dismutase and catalase (38). The role of free radical generation in producing the hyperglycemiadependent endothelial dysfunction is suggested by studies showing that in vitro and in vivo where acute effects of hyperglycemia are counterbalanced by antioxidants (39).…”

Section: Diabetes and Free Radical Productionmentioning

confidence: 99%

Effect of COVID-19 Infection on the Immune System and Risk of Developing Diabetes Complications: A Review

Derouiche

Cheradid

Abdelmalek

et al. 2020

jpc

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Coronavirus disease (COVID-19) is caused by SARS-COV2 and represents the causative agent of a potentially fatal disease that is of great global public health concern. The pandemic outbreak of COVID-19 is rapidly spreading all over the world. In this review, we try to summarize studies of the relationship between the alteration of immune system during COVID-19 infection and the risk of developing diabetes complications. The data were collected by searching Science Direct, Google Scholar, PubMed, Scopus, Springer and National Center for Biotechnology Information (NCBI). The Keywords used as search terms were “COVID-19”, “SARS-COV2 induced inflammatory reaction”, “ACE2 and COVID-19 infection”, “Diabetes and Oxidative stress” and “COVID-19 induced Diabetes complication”. The risk of COVID-19 infection in patients is due to the severity of the viral infection and also to the host's immune response. The risk of infection is one of the main complications of diabetics, as it has been suggested that diabetes inhibits the immune response which contributes to infection and progression to symptoms. Also, the evidence of generation of oxygen free radicals and oxidative stress is a key process in the onset of diabetes mellitus which participate in the development of the systemic inflammatory response syndrome. In addition, chronic hyperglycemia during COVID-19 infection may increase the release of inflammatory cytokines, a high ability to bind to the virus ACE2 glycosylated, worsen the ketoacidosis and vascular complications that may explain the severity of the SARS-CoV-2 infection in diabetic patients.

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Section: Diabetes and Free Radical Productionmentioning

confidence: 99%

Effect of COVID-19 Infection on the Immune System and Risk of Developing Diabetes Complications: A Review

Derouiche

Cheradid

Abdelmalek

et al. 2020

jpc

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“…In addition, genotoxic effects have been tested in Drosophila melanogaster [ 37 ], ground beetles [ 38 ], and bumblebees as pollinators [ 39 ]. Sublethal effects on hematological, biochemical, and histopathological parameters occurred in fish, [ 40 , 41 ], crustaceans [ 42 ], mammals [ 43 ], and humans [ 44 ].…”

Section: Introductionmentioning

confidence: 99%

Triazine Herbicide and NPK Fertilizer Exposure: Accumulation of Heavy Metals and Rare Earth Elements, Effects on Cuticle Melanization, and Immunocompetence in the Model Species Tenebrio molitor

Naccarato

Vommaro

Amico

et al. 2023

Toxics

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The increasing use of agrochemicals, including fertilizers and herbicides, has led to worrying metal contamination of soils and waters and raises serious questions about the effects of their transfer to different levels of the trophic web. Accumulation and biomagnification of essential (K, Na, Mg, Zn, Ca), nonessential (Sr, Hg, Rb, Ba, Se, Cd, Cr, Pb, As), and rare earth elements (REEs) were investigated in newly emerged adults of Tenebrio molitor exposed to field-admitted concentrations of a metribuzin-based herbicide and an NPK blend fertilizer. Chemical analyses were performed using inductively coupled plasma tandem mass spectrometry (ICP-MS/MS) supported by unsupervised pattern recognition techniques. Physiological parameters such as cuticle melanization, cellular (circulating hemocytes), and humoral (phenoloxidase enzyme activity) immune responses and mass loss were tested as exposure markers in both sexes. The results showed that NPK fertilizer application is the main cause of REE accumulation in beetles over time, besides toxic elements (Sr, Hg, Cr, Rb, Ba, Ni, Al, V, U) also present in the herbicide-treated beetles. The biomagnification of Cu and Zn suggested a high potential for food web transfer in agroecosystems. Gender differences in element concentrations suggested that males and females differ in element uptake and excretion. Differences in phenotypic traits show that exposure affects metabolic pathways involving sequestration and detoxification during the transition phase from immature-to-mature beetles, triggering a redistribution of resources between sexual maturation and immune responses. Our findings highlight the importance of setting limits for metals and REEs in herbicides and fertilizers to avoid adverse effects on species that provide ecosystem services and contribute to soil health in agroecosystems.

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Biotransformation of metribuzin under various electron acceptor conditions

Phillips

Boopathy

2022

Environmental Quality Mgmt

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Metribuzin is a triazine herbicide used in sugarcane fields to control broadleaf weeds.Metribuzin that is washed into waterways as runoff can be linked to hermaphroditism in frogs as well as algal and macrophyte death. Metribuzin degradation by bacteria is essential to reduce the half-life of metribuzin in the environment. The objective of this study was to determine metribuzin degradation by various bacterial consortia developed from a sludge collected from a sewage treatment plant. The sludge was exposed to metribuzin under various electron acceptor conditions including, nitrate reducing, sulfate reducing, and mixed electron acceptor conditions. Results showed metribuzin was removed significantly under mixed electron acceptor condition when glucose served as a co-substrate followed by sulfate reducing and nitrate reducing conditions. The major metabolites identified in metribuzin degradation were desamino-metribuzin, diketo-metribuzin, and desamino-diketo-metribuzin. Repeated exposure to metribuzin may help the bacteria to adapt and evolve metribuzin degrading enzymes.

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Triazinone herbicide metribuzin induced acute liver injury: A study of animal model

Cited by 9 publications

References 1 publication

Effect of COVID-19 Infection on the Immune System and Risk of Developing Diabetes Complications: A Review

Effect of COVID-19 Infection on the Immune System and Risk of Developing Diabetes Complications: A Review

Triazine Herbicide and NPK Fertilizer Exposure: Accumulation of Heavy Metals and Rare Earth Elements, Effects on Cuticle Melanization, and Immunocompetence in the Model Species Tenebrio molitor

Biotransformation of metribuzin under various electron acceptor conditions

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