Triazole formation of phosphinyl alkynes with azides through transient protection of phosphine by copper

Abstract

An efficient preparation method of functionalized phosphines by copper-catalyzed azide–alkyne cycloaddition (CuAAC) through the transient protection of phosphine from the Staudinger reaction is disclosed. Diverse phosphines were prepared from phosphinyl...

Radical revelations: the pnictogen effect in linear acetylenes

“…In contrast, diphosphinoacetylenes (DPAs) are far more common and stable, while being frequently used as valuable ligands in the synthesis of a wide variety of transition-metal compounds. [29][30][31] These, and other, marked differences between DAAs and their heavier analogs, such as DPAs or other dipnictogenoacetylenes (DXAs) in general, are intriguing. Although empirical evidence has sketched some trends in the underlying electronic origin of such divergences, this topic has been very scarcely studied from theoretical perspectives.…”

Sterically Demanding Novel Triazole Based Tertiary Phosphines: Synthesis, Transition Metal Chemistry and Catalytic Applications

“…Figure 1 depicts a few triazole based systems known in the literature. [19][20][21][22][23][24][25][26][27][28][29][30] Although several triazole-based phosphine ligands [19,21,24,[26][27][28][29][30][31][32][33][34][35][36] are reported, triazoles functionalized with both phosphine and bulky sidearms are rare. As a part of our continued interest in the synthesis and catalytic application of sterically demanding phosphines [27][28][29][30][31]33,36] and also of others, [32,[37][38][39][40][41][42][43] herein we report the synthesis and transition metal chemistry of bulky phosphines 3 and 4 appended with sterically demanding 1,2,3triazole core.…”

Synthesis, α-Glucosidase Inhibitory Activity and Molecular Docking Study of Chalcone Derivatives Bearing a 1<i>H</i>-1,2,3-Triazole Unit

“…25) These structures are easily accessible through click chemistry, such as azide-alkyne cycloadditions. 26) In addition, they possess unique inherent features that provide stability to the fundamental pharmacophoric unit while also serving as a bioisostere of several chemical functionalities. 27) Focusing on pharmacological advantages, they have been well-known for antidiabetic, [28][29][30] anticancer, [31][32][33] and antimicrobial [34][35][36][37][38][39] activities.…”