Triazole incorporated pyridazinones as a new class of antihypertensive agents: Design, synthesis and in vivo screening

Siddiqui, Anees A.; Mishra, Ravinesh; Shaharyar, Mohammad; Husain, Asif; Rashid, Mohd; Pal, Palash

doi:10.1016/j.bmcl.2010.12.028

Cited by 83 publications

(32 citation statements)

References 14 publications

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“…The thiosemicarbazides 75a – u conveniently synthesized by refluxing carbohydrazide derivatives 74a–g with aryl isothiocyanate 52a , b , k in refluxing ethanol (Scheme ) .…”

Section: Thiosemicarbazidesmentioning

confidence: 99%

An Update of the Use of Thiocarbohydrazides and Thiosemicarbazides in the Preparation of Heterocycles and Their Biological Importance

Aly

Hassan

AbdEl‐latief

2018

Journal of Heterocyclic Chem

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The inherent reactivity of thiocarbohydrazides and thiosemicarbazides makes them valuable as building blocks for the synthesis of other heterocyclic motifs. This review article discusses the recent applications of classes of compounds in syntheses of five‐membered to seven‐membered heterocycles of biological activities and remarkable number of metal complexes. Many previous reviews dealt with the reactivity of either thiosemicarbazides or thiocarbohydrazides. However, a large number of publications have recently dealt with the reactivity of thiosemicarbazides and thiocarbohydrazides. Consequently, we have found that it is of importance to shed new light on these interesting molecules.

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“…The thiosemicarbazides 75a – u conveniently synthesized by refluxing carbohydrazide derivatives 74a–g with aryl isothiocyanate 52a , b , k in refluxing ethanol (Scheme ) .…”

Section: Thiosemicarbazidesmentioning

confidence: 99%

An Update of the Use of Thiocarbohydrazides and Thiosemicarbazides in the Preparation of Heterocycles and Their Biological Importance

Aly

Hassan

AbdEl‐latief

2018

Journal of Heterocyclic Chem

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“…The intramolecular cyclization of benzimidazolyl thio hydrazide 95, which was prepared by the reaction of hydrazide with methylisothiocyanate, successfully provided hybrid of triazole and benzimidazole 96 with potent antioxidant activity in the presence of sodium hydroxide (Scheme 37) [133]. The similar synthetic procedure was applied to prepare pyridazinone substituted 1,2,4-triazoles which showed highly significant reduction in mean arterial blood pressure but with higher dose in comparison to standard drugs Hydralazine and Propanolol [134]. Moreover, a series of novel sulfonamide-1,2,4-triazolones (26-65%), triazole thiones (53-96%) and benzodioxane triazoles (96%) as well as phenyl triazoles were conveniently developed in the similar preparative method, and these intriguing molecules exhibited interesting bioactivities like antibacterial, antifungal and antitumor properties [135][136][137].…”

Section: Amino Thio Hydrazidesmentioning

confidence: 99%

Current Developments in the Syntheses of 1,2,4-Triazole Compounds

Zhang¹,

Damu²,

Cai³

et al. 2014

COC

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Heterocyclic 1,2,4-triazole derivatives possess unusually spacious potentiality as medicinal agents, agricultural chemicals, functional materials, ionic liquids, supramolecular catalysts as well as artificial enzymes and receptors for supramolecular recognition and biomimetic catalysis, and their various researches and developments have been being a quite rapidly developing and active highlight topic with an infinite space. Numerous efforts have been directed toward various types of possible applications of 1,2,4-triazole-based compounds and a lot of important progress has been made, especially their preparations have attracted increasing attention. This review systematically summarized the recent advances in the syntheses of 1,2,4-triazole derivatives, including: (1) Cyclizations to form triazole ring; (2) Transformations of heterocyclic compounds to construct triazole ring; (3) Substitutions on 1,2,4-triazole ring; (4) Structural modifications in side chains of 1,2,4-triazole ring. It was hoped that this review would be helpful for the design and development of highly efficient preparation of 1,2,4-triazole derivatives with various sorts and varieties of extensively potential applications in medicine, agriculture, chemistry, materials, supramolecular sciences and so on.

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“…4-fenil butanol ticari olarak bulunmaktadır ve süksinik anhidrit ve benzenden hazırlanır. [22][23][24][25][26] Eğer kullanılan benzenin içinde eser miktarda bile toluen varsa, toluen 4-(4-metilfenil)-1-butanole dönüşür. 4-(4-metilfenil)-1-butanol 4-fenil-1butanol içerisinde başlangıç madde safsızlığı olarak bulunur ve bu safsızlığın bulunuşu AFB'de metil salmeterolün safsızlık olarak bulunmasına yol açar.…”

Section: Başlangıç Maddelerindeki Safsızlıklarunclassified