Triazole incorporated thiazoles as a new class of anticonvulsants: Design, synthesis and in vivo screening

Siddiqui, Nadeem; Ahsan, Waquar

doi:10.1016/j.ejmech.2009.12.062

Cited by 178 publications

(83 citation statements)

References 18 publications

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“…Thiazoles and their derivatives have been demonstrated to possess awide range of exercise physiology and pharmaceutical activities such as antitumor [4],a nticonvulsant [5],a ntiviral [6],a ntibacterial [ 7], antimicrobial [8],and fungicidal activities [9]. Taking these results into account, we report the synthesis and crystal structure of the title compound in this paper.…”

Section: Discussionmentioning

confidence: 99%

Crystal structure of 2-(methylthio)thiazolo[4,5-c]pyridine, C7H6N2S2

Tian

Zhao

Wang³

et al. 2014

Zeitschrift Für Kristallographie - New Crystal Structures

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Section: Discussionmentioning

confidence: 99%

Crystal structure of 2-(methylthio)thiazolo[4,5-c]pyridine, C7H6N2S2

Tian

Zhao

Wang³

et al. 2014

Zeitschrift Für Kristallographie - New Crystal Structures

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“…Thiazoles and their derivatives have been demonstrated to possess a wide range of exercise physiology and pharmaceutical activities such as antitumor [4], anticonvulsant [5], antiviral [6], antibacterial [7], antimicro-bial [8], and fungicidal activities [9]. On the other hand, hydrogen bonds play an important role in crystal engineering [10] and in biological system [11].…”

Section: Discussionmentioning

confidence: 99%

Crystal structure of 1-(p-methyl benzylidene)-2-(thiazolo[5,4-b]pyridin-2- yl)hydrazine, C14H12N4S

Wei

Miao

2015

Zeitschrift Für Kristallographie - New Crystal Structures

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Source of materialThe title compound was obtained according to the literature method [12]. Single crystals suitable for X-ray diffraction were obtained by crystallization of the title compound from methanol. Experimental detailsAll of the non-hydrogen atoms were refined anisotropically. The hydrogen atoms were assigned with common isotropic displacement factors U iso (H) = 1.2 times U eq (N and aromatic ring C), or U iso (H) = 1.5 times U eq (methyl C) and included in the final refinement by using geometrical restraints, with C-H = 0.93 Å (aromatic ring) or C-H = 0.96 Å (methyl), and N-H = 0.86 Å. DiscussionThe thiazole ring has been found in many natural compounds that have useful biological activities [1][2][3] [9]. On the other hand, hydrogen bonds play an important role in crystal engineering [10] and in biological system [11]. Therefore, we report on the synthesis and crystal structure of the title compound as part of our continuing interest in these systems [12,13]. A view of the molecular structure of the title compound is given in the figure. The independent part of the unit cell contains one molecule of the title compound, which is constructed by the pyridine-thiazole moiety, the hydrazone linker, and the p-methyl benzaldehyde moiety. All non-hydrogen atoms of the title compound are almost planar with the maximum deviation is 0.1080(7) Å for C5. The C6-N3, N3-N4, and C7-N4 bond lengths are 1.343(3) Å, 1.366(3) Å, and 1.280(3) Å, respectively. The C1-S1 and C6-S1 bond lengths of 1.744(3) Å and 1.750(3) Å are intermediate between the double and single bonds. The crystal packing of the title compound exhibits intermolecule N-H×××N hydrogen bonds. Adjacent molecules are linked by the N3-H3A×××N1 i hydrogen bonds into onedimensional chain. The distance of H3A×××N1 is 2.02 Å, the distance of N3×××N1 is 2.881(3) Å, and the angle of N3-H3A×××N1 is 178.6°. Symmetry code i: x, -y+ 3 2 , z+ 1 2 .

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“…Thiazoles and their derivatives have been demonstrated to possess awide range of exercise physiology and pharmaceutical activities such as antitumor [4],a nticonvulsant [5],a ntiviral [6],a ntibacterial [7], antimicrobial [8],and fungicidal activities [9]. On the other hand, hydrogen bonds play an important role in crystal engineering [10,11] and in biological system [12].T herefore, we report on the synthesis and crystal structure of the title compound as part of our continueing interest in these systems [13][14][15].…”

Section: Discussionmentioning

confidence: 99%

Crystal structure of 1-(thiazolo[4,5-c]pyridin-2-yl)hydrazine, C6H6N4S

Zhang

2014

Zeitschrift Für Kristallographie - New Crystal Structures

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Triazole incorporated thiazoles as a new class of anticonvulsants: Design, synthesis and in vivo screening

Cited by 178 publications

References 18 publications

Crystal structure of 2-(methylthio)thiazolo[4,5-c]pyridine, C7H6N2S2

Crystal structure of 2-(methylthio)thiazolo[4,5-c]pyridine, C7H6N2S2

Crystal structure of 1-(p-methyl benzylidene)-2-(thiazolo[5,4-b]pyridin-2- yl)hydrazine, C14H12N4S

Crystal structure of 1-(thiazolo[4,5-c]pyridin-2-yl)hydrazine, C6H6N4S

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