Triazolopyridines. Part 29. Direct arylation reactions with [1,2,3]triazolo[1,5-a]pyridines

Abstract

[1,2,3]Triazolo [1,5-a]pyridine reacts with aryl halides in presence of catalytic amounts of Pd(OAc) 2 and PPh 3 in DMF to give, in medium or low yield, direct arylations in C3 and pyridyl aryl ketones. Thiazole and benzothiazole have been directly arylated using 7-halotriazolopyridines. These behaviours are unprecedented in the chemistry of [1,2,3]triazolo [1,5-a]pyridines.