Triazophos-induced oxidative stress and histomorphological changes in ovary of female Wistar rats

Sharma, Dharmender; Sangha, Gurinder Kaur; Khera, Kuldeep Singh

doi:10.1016/j.pestbp.2014.09.004

Cited by 39 publications

(19 citation statements)

References 57 publications

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“…Previously, epidemiological studies established correlations between OPs and endocrine system diseases [8,9,10] or infertility [11,12] based on urinary measurements of DEP. The endocrine-disrupting effects of OPs, including chlorpyrifos [13,14,15,16,17,18], diazinon [19,20], malathion [21], triazophos [22], and dimethoate [23], have only been proven in animal studies, which reported a disorder of hormones involved in the hypothalamic‒pituitary‒adrenal [20], hypothalamic‒pituitary‒thyroid [14,17,18,19], and hypothalamic‒pituitary‒gonadal axes [14,15,16,17,21,22,23]. All of these OPs metabolize to DEP in vivo; however, we do not know whether these effects are induced by the parent OPs or the metabolites, especially the non-specific metabolite, DEP.…”

Section: Introductionmentioning

confidence: 99%

Effects of Diethyl Phosphate, a Non-Specific Metabolite of Organophosphorus Pesticides, on Serum Lipid, Hormones, Inflammation, and Gut Microbiota

Yang

Pang

et al. 2019

Molecules

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Organophosphorus pesticides (OPs) can be metabolized to diethyl phosphate (DEP) in the gut environment, which may affect the immune and endocrine systems and the microbiota. Correlations between OPs and diseases have been established by epidemiological studies, mainly based on the contents of their metabolites, including DEP, in the serum or urine. However, the effects of DEP require further study. Therefore, in this study, adult male rats were exposed to 0.08 or 0.13 mg/kg DEP for 20 weeks. Serum levels of hormones, lipids, and inflammatory cytokines as well as gut microbiota were measured. DEP significantly enriched opportunistic pathogens, including Paraprevotella, Parabacteroides, Alloprevotella, and Helicobacter, leading to a decrease in interleukin-6 (IL-6). Exposure to the high dose of DEP enriched the butyrate-producing genera, Alloprevotella and Intestinimonas, leading to an increase in estradiol and a resulting decrease in total triglycerides (TGs) and low-density lipoprotein cholesterol (LDL-C); meanwhile, DEP-induced increases in peptide tyrosine‒tyrosine (PYY) and ghrelin were attributed to the enrichment of short-chain fatty acid-producing Clostridium sensu stricto 1 and Lactobacillus. These findings indicate that measuring the effects of DEP is not a proxy for measuring the effects of its parent compounds.

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Section: Introductionmentioning

confidence: 99%

Effects of Diethyl Phosphate, a Non-Specific Metabolite of Organophosphorus Pesticides, on Serum Lipid, Hormones, Inflammation, and Gut Microbiota

Yang

Pang

et al. 2019

Molecules

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“…The main arenas where pesticides are known to be used most commonly are industries, health care, and agriculture to eliminate pests. Evidence attests to negative effects of insecticides and pesticides on male and female fertility, while little is known about other health problems of these compounds, particularly on the reproductive function of women (Sharma et al, 2015). Reportes have been indicative of morphological and molecular changes in the ovaries due to pesticide exposure and poisoning, which could induce various reproductive anomalies, such as cycle irregularities, early puberty, and early senescence.…”

Section: Discussionmentioning

confidence: 99%

“…A study on the effect of organochlorine pesticides on oocyte maturation of star sh and mouse found that females were more likely to get toxicated than males (Sharma et al, 2015). Little is known about the effect of these pesticides on human oocytes, granulosa, maturation, and fertilization.…”

Section: Introductionmentioning

confidence: 99%

The effect of Alpha-lipoic acid in glyphosate treated granulosa cells on the human folliculogenesis genes

Kafshgiri¹,

Attaranzadeh²,

Ghasemi³

et al. 2021

Preprint

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Pesticides have a wide range of infertility in female reproductive. GLP is the most common herbicide used worldwide. The present study tended to evaluate the effects of alpha-lipoic acid (ALA) on expression of folliculogenesis genes in human granulosa cells (GCs) treated with glyphosate. In this study, GC samples were taken from infertile male patients who had tubal factors and received ICSI or IVF treatment for the first time. The medium used to culture cells was DMEM-F12 containing FBS 10%, penicillin 1%, and streptomycin 1%. The cells were treated with glyphosate (GLP) (250 µg/ml), ALA (50 µg/ml), and their mixture (250 GLP + 50 ALA) for 24 hr. The FoxO1, NOX4, Vnn1, and STAR gene expression in GCs was determined by real-time PCR. Exposure to GLP decreased gene expression Vnn1 and STAR in the GCs, while in comparison to control group, FOXO1 and NOX4 expression insignificantly increased. Further, ALA treatment decreased FOXO1, NOX4, in the GCs, and increased VNN1 and STAR gene expression. Transcriptional expression of FoxO1, NOX4 and STAR in GCs also decreased in their combinations (GLY + ALA). At the same time, the level of Vnn1 mRNA in GCs was increased. The findings showed that exposure to GLP alters the morphological structure of GCs and the expression of follicogenic genes, leading to dysfunction of the reproductive system. Moreover, the results showed that cell characteristics were preserved efficiently in human GCs exposed to ALA as an antioxidant.

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“…Pesticides have been shown to induce the production of ROS which ultimately leads to the OS (Abdollahi et al, 2004 ; Sharma et al, 2015 ). Oxidative stress (OS) occurs when the production of ROS overrides the free radical quenching capacity/antioxidant capacity of the cells, which leads to the damage of cellular biomolecules (nucleic acids, lipids and proteins) involved in structural organization of the cell (Figure 1 ; Casida and Quistad, 2004 ; Agrawal and Sharma, 2010 ).…”

Section: Introductionmentioning

confidence: 99%

Synergistic Effects of Heavy Metals and Pesticides in Living Systems

et al. 2017

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There is a widespread repeated exposure of the population to the pesticides and heavy metals of occupational and environmental origin. Such population is forced to undergo continuous stress imposed by combined exposure of the heavy metals and different classes of the pesticides used in agricultural as well as health practices. The existing reports from several workers have indicated that heavy metals and pesticides in combination may lead more severe impact on the human health when compared to their individual effects. Such a combination of pesticides and heavy metals may also change or influence the detection of exposure. Several studies in past have shown the synergistic toxic effects of heavy metals and pesticides. Such evaluations have revealed the synergistic interactions of various heavy metals and pesticides in animals as well as humans. The aim of the present article is to provide a synthesis of existing knowledge on the synergistic effects of heavy metal and pesticides in living systems. The information included in this article may be useful for different environment protection agencies and policy makers to consider the combined effects of heavy metals and pesticides on humans while designing strategies toward environmental protection and safety regulations about human health.

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Triazophos-induced oxidative stress and histomorphological changes in ovary of female Wistar rats

Cited by 39 publications

References 57 publications

Effects of Diethyl Phosphate, a Non-Specific Metabolite of Organophosphorus Pesticides, on Serum Lipid, Hormones, Inflammation, and Gut Microbiota

Effects of Diethyl Phosphate, a Non-Specific Metabolite of Organophosphorus Pesticides, on Serum Lipid, Hormones, Inflammation, and Gut Microbiota

The effect of Alpha-lipoic acid in glyphosate treated granulosa cells on the human folliculogenesis genes

Synergistic Effects of Heavy Metals and Pesticides in Living Systems

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