2015
DOI: 10.1042/bst20150095
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Tribbles in inflammation

Abstract: Inflammation is part of the physiological innate immune response to invading pathogens and tissue injury. However, unresolved inflammation leads to human disease. The tribbles (TRIB) family of pseudokinase proteins has been shown to modulate key inflammatory signalling pathways, including the MAPK (mitogen-activated protein kinase) and PI3K (phosphoinositide 3-kinase) networks. This review summarizes our current knowledge on TRIBs in the context of inflammation, both at the level of molecular mechanisms and in… Show more

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Cited by 24 publications
(23 citation statements)
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“…Tribbles have previously been shown to regulate inflammatory signalling, one of the molecular mechanisms being via their interaction with MAPKKs141523243132. However, the dynamics of TRIB/MAPKK complex formation and the relationship between TRIBs and MAPKs is currently unclear.…”
Section: Resultsmentioning
confidence: 99%
See 2 more Smart Citations
“…Tribbles have previously been shown to regulate inflammatory signalling, one of the molecular mechanisms being via their interaction with MAPKKs141523243132. However, the dynamics of TRIB/MAPKK complex formation and the relationship between TRIBs and MAPKs is currently unclear.…”
Section: Resultsmentioning
confidence: 99%
“…Since the original description of tribbles as regulators of morphogenesis and several signalling pathways, this family of proteins have increasingly been recognised as an important controller of cellular processes; dysregulation of tribbles expression/function has been implicated in a number of diseases, including hyperlipidaemia and myocardial infarction (reviewed in refs 14,40,41). One significant aspect of tribbles action, still ill defined, is the specificity and redundancy between the three mammalian proteins.…”
Section: Discussionmentioning
confidence: 99%
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“…TRIB1 was also shown to interact with MAP kinases and mediate signaling changes to MAPK cascades through mechanisms that are likely independent of COP1 (15, 16, 20 -23). Although we and others have previously demonstrated a function for Trib1 in lipid metabolism (24 -26), Trib1 has also been connected to inflammation (27,28) and macrophage biology (29,30). With regards to macrophages, Trib1 deficiency altered the expression of inflammation induced genes in peritoneal macrophages in a C/EBP␤-dependent manner (30).…”
mentioning
confidence: 82%
“…The second involves a more obscure scaffolding function, which operates to integrate and modulate signals flowing into and through canonical MAPK and AKT modules (Figure 1). Accordingly, TRIBs are fundamental regulators of cell cycle, differentiation, metabolism, proliferation, and cell stress, as reflected by the appearance of several excellent reviews in these specific areas 5, 6, 7, 8, 9.…”
Section: Introduction and Historical Perspectivementioning
confidence: 99%