Tribo-mechanical and biological characterization of PEGDA/bioceramics composites fabricated using stereolithography

Kumar, Mohit; Ghosh, Souvik; Kumar, Viney; Sharma, Varun; Roy, Partha

doi:10.1016/j.jmapro.2022.03.024

Cited by 26 publications

(9 citation statements)

References 45 publications

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“…In recent decades, the PEGDA hydrogel has become increasingly popular in biomedical applications because of its excellent biocompatibility, lack of toxicity, and straightforward manufacturing process. 8,9,12,13 PEGDA hydrogels are used widely in bone regeneration, 13,14 neural tissue engineering, 9 the replacement of heart valves, and many other biomedical applications. During the past few years, researchers have explored the mechanical strength of these hydrogels.…”

Section: Introductionmentioning

confidence: 99%

Effect of the degree of polymerization and water content on the thermal transport phenomena in PEGDA hydrogel: a molecular-dynamics-based study

Kumar¹,

Parashar²

2023

Phys. Chem. Chem. Phys.

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Section: Introductionmentioning

confidence: 99%

Effect of the degree of polymerization and water content on the thermal transport phenomena in PEGDA hydrogel: a molecular-dynamics-based study

Kumar¹,

Parashar²

2023

Phys. Chem. Chem. Phys.

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“…However, an increase in HA loading to 2 wt% decreased the compressive modulus due to the agglomeration of HA nanoparticles. In another study, Kumar et al [56] demonstrated that SLA-printed PEGDA-HAP scaffolds with 1 wt% HA reached a compressive modulus of approximately 50 MPa, which was not significantly different from unfilled PEGDA.…”

Section: Analysis Of Compressive Modulus Influenced By Ha Concentrationmentioning

confidence: 97%

Development and optimisation of hydroxyapatite-polyethylene glycol diacrylate hydrogel inks for 3D printing of bone tissue engineered scaffolds

Rajabi,

Cabral,

Saunderson

et al. 2023

Biomed. Mater.

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In the event of excessive damage to bone tissue, the self-healing process alone is not sufficient to restore bone integrity. Three-dimensional (3D) printing, as an advanced additive manufacturing technology, can create implantable bone scaffolds with accurate geometry and internal architecture, facilitating bone regeneration. This study aims to develop and optimise hydroxyapatite-polyethylene glycol diacrylate (HA-PEGDA) hydrogel inks for extrusion 3D printing of bone tissue scaffolds. Different concentrations of HA were mixed with PEGDA, and further incorporated with pluronic F127 (PF127) as a sacrificial carrier. PF127 provided good distribution of HA nanoparticle within the scaffolds and improved the rheological requirements of HA-PEGDA inks for extrusion 3D printing without significant reduction in the HA content after its removal. Higher printing pressures and printing rates were needed to generate the same strand diameter when using a higher HA content compared to a lower HA content. Scaffolds with excellent shape fidelity up to 75-layers and high resolution (∼200 µm) with uniform strands were fabricated. Increasing the HA content enhanced the compression strength and decreased the swelling degree and degradation rate of 3D printed HA-PEGDA scaffolds. In addition, the incorporation of HA improved the adhesion and proliferation of human bone mesenchymal stem cells (hBMSCs) onto the scaffolds. 3D printed scaffolds with 2 wt% HA promoted osteogenic differentiation of hBMSCs as confirmed by the expression of alkaline phosphatase activity and calcium deposition. Altogether, the developed HA-PEGDA hydrogel ink has promising potential as a scaffold material for bone tissue regeneration, with excellent shape fidelity and the ability to promote osteogenic differentiation of hBMSCs.

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“…It has, thromboresistance, chemical inertia, and physical characteristics similar to bone. HA has a similar composition to bone minerals and excellent biocompatibility; therefore, widely used as a bone substitute [6][7][8]. However, synthetic HA is brittle, rigid, has low solubility, and poor processability [9,10].…”

Section: Introductionmentioning

confidence: 99%

Process Parameter Optimization of 3D-Printer Machine Using Response Surface Method for Printing Hydroxyapatite/Collagen Composite Slurry

Nurbaiti,

Tontowi,

Widyastuti

et al. 2023

IJE

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Tribo-mechanical and biological characterization of PEGDA/bioceramics composites fabricated using stereolithography

Cited by 26 publications

References 45 publications

Effect of the degree of polymerization and water content on the thermal transport phenomena in PEGDA hydrogel: a molecular-dynamics-based study

Effect of the degree of polymerization and water content on the thermal transport phenomena in PEGDA hydrogel: a molecular-dynamics-based study

Development and optimisation of hydroxyapatite-polyethylene glycol diacrylate hydrogel inks for 3D printing of bone tissue engineered scaffolds

Process Parameter Optimization of 3D-Printer Machine Using Response Surface Method for Printing Hydroxyapatite/Collagen Composite Slurry

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