Triboelectrification: A review of experimental and mechanistic modeling approaches with a special focus on pharmaceutical powders

Naik, Shivangi; Mukherjee, Raj; Chaudhuri, Bodhisattwa

doi:10.1016/j.ijpharm.2016.06.031

Cited by 44 publications

(20 citation statements)

References 109 publications

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“…Particles in granular flows and fluidization may acquire electrostatic charges through repeated contact with bounding walls and other particles, a process known as triboelectrification or tribocharging. While tribocharging of conductors (metals) is fairly well understood, the charging mechanism for insulators remains an open question; further discussion on tribocharging is available in many articles (102)(103)(104)(105). Electrostatic charge generation in fluidized beds affects bubble shapes (106), fine particle elutriation (107), and the extent of lateral segregation (108,109).…”

Section: Real Systems Have Further Complexitiesmentioning

confidence: 99%

Toward Constitutive Models for Momentum, Species, and Energy Transport in Gas–Particle Flows

Sundaresan

Özel

Kolehmainen

2018

Annu. Rev. Chem. Biomol. Eng.

153

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As multiscale structures are inherent in multiphase flows, constitutive models employed in conjunction with transport equations for momentum, species, and energy are scale dependent. We suggest that this scale dependency can be better quantified through deep learning techniques and formulation of transport equations for additional quantities such as drift velocity and analogies for species, energy, and momentum transfer. How one should incorporate interparticle forces, which arise through van der Waals interaction, dynamic liquid bridges between wet particles, and tribocharging, in multiscale models warrants further study. Development of multiscale models that account for all the known interactions would improve confidence in the use of simulations to explore design options, decrease the number of pilot-scale experiments, and accelerate commercialization of new technologies.

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Section: Real Systems Have Further Complexitiesmentioning

confidence: 99%

Toward Constitutive Models for Momentum, Species, and Energy Transport in Gas–Particle Flows

Sundaresan

Özel

Kolehmainen

2018

Annu. Rev. Chem. Biomol. Eng.

153

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“…5). The net magnitude of charges decreases significantly for pharmaceutical mixtures 6 compared to individual materials even at low humidity conditions. The net charge dropped sharply for most of the combinations with the increase in humidity and became negligible at 60% RH.…”

Section: Triboelectric Studiesmentioning

confidence: 98%

“…[1][2][3][4] Electrostatic charging, van der Waal's interactions, and the formation of liquid bridges are all variable functions of moisture concentration, while the moisture content itself may again vary from material to material, and at different humidity conditions. Liquid bridge induced cohesion dominates the cohesive behavior at higher moisture contents, 5 whereas at low moisture contents electrostatic charging 6 and van der Waal's forces are the dominant interactions. 7 Flow behaviors may be further hindered by an increase in humidity due to the formation of solid bridges 8 and also due to phase changes in amorphous materials due to a decrease in glass-transition temperature.…”

Section: Introductionmentioning

confidence: 99%

Quantification of Moisture-Induced Cohesion in Pharmaceutical Mixtures

Mukherjee

Sen

Fontana

et al. 2019

Journal of Pharmaceutical Sciences

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Moisture-induced flow variabilities in pharmaceutical blends lead to multiple impediments during manufacturing of solid dosage formulations. Processing and storage humidity conditions both govern the moisture contents of the pharmaceutical mixtures and bear significant impact on the final product quality. In this study, experimentally validated discrete element method-based computational models along with statistical formalism have been implemented to develop a predictive tool for moisture-induced cohesion in binary and tertiary mixtures. V-blending was applied to prepare the pharmaceutical blends, and mixing characterization was performed using a Raman PhAT probe. Optimum fill volume was established for the mixing conditions to minimize static charging due to blender wall interactions on the pharmaceutical powders. A simplex-centroid (augmented) design for 3-component system was implemented to predict and quantify the nonlinear behavior of moisture-induced cohesion between the pharmaceutical powders based on their systematic hopper discharge studies (experiments and simulations). A methodical implementation of these quantification tools was hence performed to validate a design space that enables an approach to the appropriate selection of blend concentrations that achieve minimum mixture flow variability across different humidity conditions.

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“…Nowadays, work functions can be measured with photoemission spectroscopy and the Kevin-Zisman method [32,33]. Because fermi level will be introduced for the work function calculation, metals will be considered as important surface materials if the electron transfer dominates [31,34].…”

Section: Electronmentioning

confidence: 99%

Fundamental theories and basic principles of triboelectric effect: A review

2018

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Long-term observation of the triboelectric effect has not only proved the feasibility of many novel and useful tribo-devices (e.g., triboelectric nanogenerators), but also constantly motivated the exploration of its mysterious nature. In the pursuit of a comprehensive understanding of how the triboelectric process works, a more accurate description of the triboelectric effect and its related parameters and factors is urgently required. This review critically goes through the fundamental theories and basic principles governing the triboelectric process. By investigating the difference between each charging media, the electron, ion, and material transfer is discussed and the theoretical deduction in the past decades is provided. With the information from the triboelectric series, interesting phenomena including cyclic triboelectric sequence and asymmetric triboelectrification are precisely analyzed. Then, the interaction between the tribo-system and its operational environment is analyzed, and a fundamental description of its effects on the triboelectric process and results is summarized. In brief, this review is expected to provide a strong understanding of the triboelectric effect in a more rigorous mathematical and physical sense.

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Triboelectrification: A review of experimental and mechanistic modeling approaches with a special focus on pharmaceutical powders

Cited by 44 publications

References 109 publications

Toward Constitutive Models for Momentum, Species, and Energy Transport in Gas–Particle Flows

Toward Constitutive Models for Momentum, Species, and Energy Transport in Gas–Particle Flows

Quantification of Moisture-Induced Cohesion in Pharmaceutical Mixtures

Fundamental theories and basic principles of triboelectric effect: A review

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